Published in:
Open Access
01-12-2013 | Poster presentation
PReS-FINAL-2113: The association of the NFKB1 gene polymorphism with systemic onset juvenile idiopathic arthritis in Russia
Authors:
VA Malievsky, TV Viktorova, KV Danilko, LS Nazarova
Published in:
Pediatric Rheumatology
|
Special Issue 2/2013
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Excerpt
Juvenile idiopathic arthritis (JIA) is a childhood onset autoimmune disorder characterized by inflammation of joints and other tissues. The basis for susceptibility to common autoimmune and inflammatory diseases, including JIA, is a complex interplay between multiple genetic and environmental risk factors. NF-κb appears to be a central player in several autoimmune diseases, according to recent studies of genetic defects in autoreactive lymphoid cells in both murine models of autoimmunity and humans with diverse forms of autoimmunity. Meta-analysis suggested a possible association between NFKB1 -94 ins/delattg promoter polymorphism and certain autoimmune and inflammatory diseases in the Asian population, but not in the Caucasian population. …
