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Open Access 01-11-2013 | Meeting abstract

PW01-015 – Canakinumab in adults with colchicin resistant FMF

Authors: A Gül, H Özdoğan, Ö Kasapçopur, B Erer, S Uğurlu, N Davis, S Sevgi

Published in: Pediatric Rheumatology | Special Issue 1/2013

Excerpt

Familial Mediterranean fever (FMF) is associated with variations in the MEFV gene resulting in proteolytic activation of IL-1β through the inflammasome complex. There is no established treatment available for those resistant or intolerant to standard of care colchicine treatment. Canakinumab, a fully human selective anti-IL-1β monoclonal antibody with a half-life of ~4-weeks binds to human IL-1β and neutralizes its proinflammatory effects. …

Title: PW01-015 – Canakinumab in adults with colchicin resistant FMF
Authors: A Gül
H Özdoğan
Ö Kasapçopur
B Erer
S Uğurlu
N Davis
S Sevgi
Publication date: 01-11-2013
Publisher: BioMed Central
Published in: Pediatric Rheumatology / Issue Special Issue 1/2013
Electronic ISSN: 1546-0096
DOI: https://doi.org/10.1186/1546-0096-11-S1-A68

At a glance: The STEP trials

Springer Medicine

PW01-015 – Canakinumab in adults with colchicin resistant FMF

Excerpt

At a glance: The STEP trials

Springer Medicine

Excerpt

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OR7-005 – Canakinumab in childhood colchicine resistant FMF

PW02-002 - Single MVK mutation and recurrent fevers

PW02-020 - Colitis revealing mevalonate kinase deficiency

PW02-031 - Genetic and clinical manifestations of CAPS

PW02-006 - PAPA syndrome clinical spectrum and IL1B release

P01-032 – Characterization of genetic-negative FMF