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Open Access 01-11-2013 | Meeting abstract

PW03-027 - CASP1 variants and live cell imaging

Authors: S Rabe, MC Heymann, S Russ, S Winkler, J Roesler, A Rösen-Wolff, SR Hofmann

Published in: Pediatric Rheumatology | Special Issue 1/2013

Excerpt

Patients with unexplained recurrent febrile episodes and CASP1 variants suffer from systemic sterile inflammation despite reduced secretion of IL-1ß. As previously demonstrated by our group CASP1 variants lead to reduced enzymatic activity of procaspase-1 by destabilizing the tertiary structure of the caspase-1 tetramer. A possible explanation for an alternative pro-inflammatory pathway has been provided by Lamkanfi and colleagues indicating an association between enzymatically inactive procaspase-1 and receptor interacting protein kinase 2 (RIP2) leading to NF-kB activation. …

Title: PW03-027 - CASP1 variants and live cell imaging
Authors: S Rabe
MC Heymann
S Russ
S Winkler
J Roesler
A Rösen-Wolff
SR Hofmann
Publication date: 01-11-2013
Publisher: BioMed Central
Published in: Pediatric Rheumatology / Issue Special Issue 1/2013
Electronic ISSN: 1546-0096
DOI: https://doi.org/10.1186/1546-0096-11-S1-A253

At a glance: The STEP trials

Springer Medicine

PW03-027 - CASP1 variants and live cell imaging

Excerpt

At a glance: The STEP trials

Springer Medicine

Excerpt

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