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Pediatric Rheumatology
Published in: Pediatric Rheumatology 1/2013

Open Access 01-11-2013 | Meeting abstract

PW03-026 - Caspase-1 variants involved in ER stress

Authors: H Luksch, V Schlipfenbacher, S Winkler, J Roesler, A Rösen-Wolff

Published in: Pediatric Rheumatology | Special Issue 1/2013

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Excerpt

Caspase-1 is a proinflammatory enzyme that is activated by the NLRP3 inflammasome in response to endoplasmic reticulum (ER) stress independent of the classical unfolded protein response. This finding linked ER stress to chronic inflammatory diseases. In patients suffering from unexplained recurrent febrile episodes we detected several genetic variants of CASP1 leading to reduced enzymatic activity due to destabilization of the caspase-1 dimer interface. …
Metadata
Title
PW03-026 - Caspase-1 variants involved in ER stress
Authors
H Luksch
V Schlipfenbacher
S Winkler
J Roesler
A Rösen-Wolff
Publication date
01-11-2013
Publisher
BioMed Central
Published in
Pediatric Rheumatology / Issue Special Issue 1/2013
Electronic ISSN: 1546-0096
DOI
https://doi.org/10.1186/1546-0096-11-S1-A252

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