Published in:
Open Access
01-11-2013 | Meeting abstract
PW03-025 - Procaspase-1 contributes to inflammation via NF-KB
Authors:
M Heymann, S Winkler, S Özen, E Yilmaz, T Kallinich, A Rösen-Wolff, J Roesler, S Hofmann
Published in:
Pediatric Rheumatology
|
Special Issue 1/2013
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Excerpt
Caspase-1 is a pro-inflammatory enzyme which gets activated by autoprocessing following the assembly of multiprotein complexes called inflammasomes. Mature caspase-1 is responsible for the activation of the pro-inflammatory cytokines interleukin (IL)-1β and IL-18. Luksch and colleagues reported naturally occurring CASP1 genetic variants in patients suffering from unexplained recurrent febrile episodes. Paradoxically, in vitro and in vivo analyses revealed decreased enzymatic activity of these caspase-1 variants leading to impaired cytokine production. A study of Lamkanfi and colleagues provides a possible explanation by indicating a link between enzymatically inactive procaspase-1 and activation of NF-κB, a pro-inflammatory transcription factor. …
