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Pediatric Rheumatology
Published in: Pediatric Rheumatology 1/2013

Open Access 01-11-2013 | Meeting abstract

PW03-024 - A transgenic mouse model for variant procaspase-1

Authors: A Hermsdorf, F Pessler, H Luksch, S Winkler, R Naumann, J Roesler, A Roers, A Rösen-Wolff

Published in: Pediatric Rheumatology | Special Issue 1/2013

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Excerpt

We have detected several genetic variants of CASP1 in patients suffering from unexplained recurrent febrile episodes. Paradoxically, in vitro and in vivo analyses of patients’ cells revealed decreased enzymatic activity of these caspase-1 variants leading to impaired cytokine production despite the proinflammatory phenotype of the patients. The pathophysiological processes associated with CASP1 variants are still under investigation. …
Metadata
Title
PW03-024 - A transgenic mouse model for variant procaspase-1
Authors
A Hermsdorf
F Pessler
H Luksch
S Winkler
R Naumann
J Roesler
A Roers
A Rösen-Wolff
Publication date
01-11-2013
Publisher
BioMed Central
Published in
Pediatric Rheumatology / Issue Special Issue 1/2013
Electronic ISSN: 1546-0096
DOI
https://doi.org/10.1186/1546-0096-11-S1-A250

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