Published in:
Open Access
01-11-2013 | Meeting abstract
PW03-014 - TLR4 and MEFV variants are Behçet's risk factors
Authors:
Y Kirino, Q Zhou, Y Ishigatsubo, N Mizuki, Y Kim, DL Kastner, A Gül, EF Remmers
Published in:
Pediatric Rheumatology
|
Special Issue 1/2013
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Excerpt
Genome-wide association studies (GWAS) are a powerful means for identifying genes with disease-associated common variants, but they are not well-suited to detect genes with disease-associated rare or low-frequency variants. It has long been debated whether the innate immune system is involved in the pathogenesis of Behçet's disease (BD) but genetic evidence to support this hypothesis is sparse. …