Published in:
Open Access
01-11-2013 | Meeting abstract
PW03-013 - Behçet's disease: genotype-phenotype correlations
Authors:
M Takeuchi, T Kawagoe, A Meguro, Y Ishigatsubo, E Remmers, D Kastner, N Mizuki
Published in:
Pediatric Rheumatology
|
Special Issue 1/2013
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Excerpt
Although the therapy for Behçet's disease (BD) has improved since infliximab was approved for refractory retinochoroiditis therapy in Japan, the exact pathogenesis of BD remains unclear. Our recent genome-wide association study has identified the IL10 and IL23R-IL12RB2 loci as susceptibility genes for BD, in addition to HLA-A*26 and B*51. rs1495965 is located in the intergenic region between IL23R and IL12RB2 and rs1800872 is located in the promoter region of IL10. IL-10 is an anti-inflammatory cytokine that may have multiple effects in immunoregulation and inflammation. It is thought that regulatory T cell function related to IL-10 is an important factor in the disease pathogenesis. …
