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Pediatric Rheumatology
Published in: Pediatric Rheumatology 1/2013

Open Access 01-11-2013 | Meeting abstract

PW03-010 - MHC complexity in Behçet's disease

Authors: MJ Ombrello, Y Kirino, P de Bakker, F Cosan, DL Kastner, A Gul, EF Remmers

Published in: Pediatric Rheumatology | Special Issue 1/2013

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Excerpt

Family studies support a genetic contribution to Behçet's disease (BD), with a sibling recurrence-risk ratio of 11-52. The class I MHC molecule, HLA-B*51 (B*51), is the strongest known genetic risk factor for BD, however the gene immediately centromeric to HLA-B, MICA, has also been implicated in BD. Because of strong linkage disequilibrium (LD) between HLA-B and MICA, their respective contributions to BD susceptibility have been debated. A recent report has proposed that B*51 is not a BD susceptibility allele, and several studies have identified B*51- independent association signals within the MHC. …
Metadata
Title
PW03-010 - MHC complexity in Behçet's disease
Authors
MJ Ombrello
Y Kirino
P de Bakker
F Cosan
DL Kastner
A Gul
EF Remmers
Publication date
01-11-2013
Publisher
BioMed Central
Published in
Pediatric Rheumatology / Issue Special Issue 1/2013
Electronic ISSN: 1546-0096
DOI
https://doi.org/10.1186/1546-0096-11-S1-A236

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