Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
Pediatric Rheumatology
Published in: Pediatric Rheumatology 1/2013

Open Access 01-11-2013 | Meeting abstract

PW03-005 - NLRP3-Q705K monocytes do not produce more IL-1B

Authors: G Simon, N Busso, A von Scheven-Gete, I Moix, M Morris, A So, M Hofer

Published in: Pediatric Rheumatology | Special Issue 1/2013

Login to get access

Excerpt

PFAPA is a pediatric auto-inflammatory syndrome of unknown etiology, characterized by recurrent fever, aphthosis, pharyngitis and cervical adenitis. Dysregulated monocyte interleukin-1 beta (IL-1β) secretion is thought to play an important role in fever flares. Recently, it was published that Thp1 cells (a monocytic cell line) transduced with the Q705K variant of NLRP3 increased IL-1β secretion after alum (an adjuvant used in vaccines) stimulation. …
Metadata
Title
PW03-005 - NLRP3-Q705K monocytes do not produce more IL-1B
Authors
G Simon
N Busso
A von Scheven-Gete
I Moix
M Morris
A So
M Hofer
Publication date
01-11-2013
Publisher
BioMed Central
Published in
Pediatric Rheumatology / Issue Special Issue 1/2013
Electronic ISSN: 1546-0096
DOI
https://doi.org/10.1186/1546-0096-11-S1-A231

Other articles of this Special Issue 1/2013

Pediatric Rheumatology 1/2013 Go to the issue

Meeting abstract

P01-020 – Starting time of inflammatory attacks in patients

Meeting abstract

P03-001 - PFAPA and MEFV genes

Meeting abstract

P02-011 - TRAPS syndrome debuted as systemic JIA

Meeting abstract

PW03-028 – Atypical presentation of CRMO in two children

Meeting abstract

PW03-017 – Combination TNF and IL-1 blockade in PAPA syndrome

Meeting abstract

P03-024 – Early onset IBD treated by tocilizumab