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Pediatric Rheumatology
Published in: Pediatric Rheumatology 1/2013

Open Access 01-11-2013 | Meeting abstract

OR11-006 - A mutation in NLRP1A causes autoinflammation

Authors: SL Masters, M Gerlic, BT Kile, BA Croker

Published in: Pediatric Rheumatology | Special Issue 1/2013

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Excerpt

The NLRs (Nucleotide-binding domain and Leucine-rich repeat containing Receptors) are a family of intracellular innate immune receptors involved in host defense. Upon activation, NLRs form large protein complexes called “inflammasomes” that bind and activate Caspase-1, resulting in proteolytic activation of the pro-inflammatory cytokines pro-IL-1β and pro-IL-18 and also induce a Caspase-1-dependent form of cell death known as pyroptosis. …
Metadata
Title
OR11-006 - A mutation in NLRP1A causes autoinflammation
Authors
SL Masters
M Gerlic
BT Kile
BA Croker
Publication date
01-11-2013
Publisher
BioMed Central
Published in
Pediatric Rheumatology / Issue Special Issue 1/2013
Electronic ISSN: 1546-0096
DOI
https://doi.org/10.1186/1546-0096-11-S1-A195

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