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Open Access 01-11-2013 | Meeting abstract

OR10-006 - Canakinumab in patients with TRAPS

Authors: HJ Lachmann, L Obici, A Meini, V Tormey, K Abrams, N Davis, C Andrews, SG Bhansali, M Gattorno

Published in: Pediatric Rheumatology | Special Issue 1/2013

Excerpt

TNF-receptor associated periodic syndrome (TRAPS) is a rare, dominantly inherited periodic fever syndrome due to mutations of the TNFRSF1A gene. The IL-1 receptor antagonist anakinra has been reported to be an efficacious daily treatment. Canakinumab (CAN) is a fully human monoclonal selective anti-IL-1β antibody with a T_1/2 of ~4 wks. Interim clinical and PK data of CAN treatment in patients with active TRAPS are presented. …

Title: OR10-006 - Canakinumab in patients with TRAPS
Authors: HJ Lachmann
L Obici
A Meini
V Tormey
K Abrams
N Davis
C Andrews
SG Bhansali
M Gattorno
Publication date: 01-11-2013
Publisher: BioMed Central
Published in: Pediatric Rheumatology / Issue Special Issue 1/2013
Electronic ISSN: 1546-0096
DOI: https://doi.org/10.1186/1546-0096-11-S1-A189

At a glance: The STEP trials

Springer Medicine

OR10-006 - Canakinumab in patients with TRAPS

Excerpt

At a glance: The STEP trials

Springer Medicine

Excerpt

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