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Pediatric Rheumatology
Published in: Pediatric Rheumatology 1/2013

Open Access 01-11-2013 | Meeting abstract

PW02-042 - Induction of MDSC in Muckle-Wells syndrome

Authors: N Rieber, A Brand, D Neri, T Hall, I Schäfer, S Hansmann, J Kümmerle-Deschner, D Hartl

Published in: Pediatric Rheumatology | Special Issue 1/2013

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Excerpt

Muckle-Wells syndrome (MWS) is caused by mutations in the NLRP3-gene encoding cryopyrin, leading to overproduction of IL-1β and other NLRP3 inflammasome products. Myeloid-derived suppressor cells (MDSCs) represent a novel innate immune cell subset, are generated in tumor, infective, and proinflammatory microenvironments and are capable of suppressing T cell responses. Consequently, MDSCs are considered a key intermediary in balancing innate and adaptive immune responses, particularly under chronic disease conditions. …
Metadata
Title
PW02-042 - Induction of MDSC in Muckle-Wells syndrome
Authors
N Rieber
A Brand
D Neri
T Hall
I Schäfer
S Hansmann
J Kümmerle-Deschner
D Hartl
Publication date
01-11-2013
Publisher
BioMed Central
Published in
Pediatric Rheumatology / Issue Special Issue 1/2013
Electronic ISSN: 1546-0096
DOI
https://doi.org/10.1186/1546-0096-11-S1-A183

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