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Open Access 01-11-2013 | Meeting abstract

PW02-025 - Programme necrosis by CAPS-associated NLRP3

Authors: T Satoh, N Kambe, H Matsue

Published in: Pediatric Rheumatology | Special Issue 1/2013

Excerpt

Cryopyrin-associated periodic syndrome (CAPS), clinically characterized by neutrophil-rich urticarial rash, is associated with missense mutations in NLRP3. NLRP3 is a pattern recognition receptor in the cytoplasm of cells and structurally related to plant resistance proteins, which detect pathogen- or danger-associated signals, leading to programmed cell death and hyper response at the local site in plants. In mammals, activated NLRP3 forms inflammasome, which orchestrates the early inflammatory process via IL-1β activation, and also cause programmed necrotic cell death termed “pyronecrosis”. However, the mechanistic details are largely unknown. …

Title: PW02-025 - Programme necrosis by CAPS-associated NLRP3
Authors: T Satoh
N Kambe
H Matsue
Publication date: 01-11-2013
Publisher: BioMed Central
Published in: Pediatric Rheumatology / Issue Special Issue 1/2013
Electronic ISSN: 1546-0096
DOI: https://doi.org/10.1186/1546-0096-11-S1-A166

At a glance: The STEP trials

Springer Medicine

PW02-025 - Programme necrosis by CAPS-associated NLRP3

Excerpt

At a glance: The STEP trials

Springer Medicine

Excerpt

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