Response of pediatric uveitis to TNFα inhibitors

Excerpt

Non-infectious uveitis (“uveitis”) is an important cause of visual loss amongst children. Although TNFα inhibitors (anti-TNFα) are increasingly used to treat pediatric uveitis, the outcomes of treatment with these agents have been poorly described. We are studying the largest, and only multicenter, group of patients with pediatric uveitis in order to more precisely estimate the outcomes of treatment with anti-TNFα and to evaluate which factors increase the likelihood of achieving uveitis quiescence after treatment. The final cohort will include subjects from the five-center Systemic Immunosuppressive Therapy for Eye Diseases Cohort Study, The Children’s Hospital of Philadelphia (CHOP), and Hershey Medical Center. Here we report preliminary results from subjects at CHOP. …