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Published in: Pediatric Rheumatology 1/2012

Open Access 01-07-2012 | Oral presentation

Systemic juvenile idiopathic arthritis is associated with HLA-DRB1 in Europeans and Americans of European descent

Authors: Michael Ombrello, Elaine F Remmers, Alexei A Grom, Wendy Thomson, Alberto Martini, Marco Gattorno, Seza Ozen, Ahmet Gul, John F Bohnsack, Andrew S Zeft, Elizabeth D Mellins, Jane L Park, Claudio Len, Colleen Satorius, Ricardo AG Russo, Terri H Finkel, Rae SM Yeung, Rayfel Schneider, Sampath Prahalad, David N Glass, Roger C Allen, Nico Wulffraat, Pierre Quartier, Maria Odete E Hilario, Kevin Murray, Sheila Oliveira, Jordi Anton, Anne Hinks, Eleftheria Zeggini, Carl Langefeld, Susan Thompson, Jeffrey Chaitow, Justine Ellis, Davinder Singh, Andre Cavalvanti, Blanca Bica, Flavio Sztajnbok, Hakon Hakonarson, Katherine A Siminovitch, Kirsten Minden, Peter Haas, Tobias Schwarz, Daniel L Kastner, Patricia Woo

Published in: Pediatric Rheumatology | Special Issue 1/2012

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Excerpt

Systemic juvenile idiopathic arthritis (sJIA) is a complex inflammatory disease whose etiology remains unknown. sJIA is distinguished from other forms of juvenile idiopathic arthritis (JIA) by its characteristic features including requisite quotidian fever and salmon-colored, evanescent skin rash, but also by an absence of autoantibodies. Based on its unique phenotype among JIA subtypes, it has been suggested that sJIA may be autoinflammatory rather than autoimmune in nature, and consistent with this, sJIA is distinct among JIA subtypes for its inconsistently detectable association with HLA genes. In this study, we sought to use SNP genotyping in a large patient collection to identify sJIA susceptibility loci. …
Metadata
Title
Systemic juvenile idiopathic arthritis is associated with HLA-DRB1 in Europeans and Americans of European descent
Authors
Michael Ombrello
Elaine F Remmers
Alexei A Grom
Wendy Thomson
Alberto Martini
Marco Gattorno
Seza Ozen
Ahmet Gul
John F Bohnsack
Andrew S Zeft
Elizabeth D Mellins
Jane L Park
Claudio Len
Colleen Satorius
Ricardo AG Russo
Terri H Finkel
Rae SM Yeung
Rayfel Schneider
Sampath Prahalad
David N Glass
Roger C Allen
Nico Wulffraat
Pierre Quartier
Maria Odete E Hilario
Kevin Murray
Sheila Oliveira
Jordi Anton
Anne Hinks
Eleftheria Zeggini
Carl Langefeld
Susan Thompson
Jeffrey Chaitow
Justine Ellis
Davinder Singh
Andre Cavalvanti
Blanca Bica
Flavio Sztajnbok
Hakon Hakonarson
Katherine A Siminovitch
Kirsten Minden
Peter Haas
Tobias Schwarz
Daniel L Kastner
Patricia Woo
Publication date
01-07-2012
Publisher
BioMed Central
Published in
Pediatric Rheumatology / Issue Special Issue 1/2012
Electronic ISSN: 1546-0096
DOI
https://doi.org/10.1186/1546-0096-10-S1-A6

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