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Pediatric Rheumatology
Published in: Pediatric Rheumatology 1/2012

Open Access 01-07-2012 | Oral presentation

Chimeric maternal cells as T lymphocyte targets in pediatric SLE

Authors: Anne M Stevens, Matthew Crabtree, Gretchen Henstorf, J Lee Nelson

Published in: Pediatric Rheumatology | Special Issue 1/2012

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Excerpt

Maternal cells routinely pass into the fetus, with increased frequency during complicated pregnancies. Engraftment of maternal cells into fetal organs such as heart and kidney may persist for decades after birth. Thus, SLE target organs normally harbor maternal cells that may express immunoreactive maternal proteins not shared by the child. Loss of tolerance to non-shared maternal antigens could lead to chronic activation of the child’s T lymphocytes, with subsequent autoimmunity through a mechanism of epitope spreading, similar to the graft-versus-host disease seen after transplantation of parental stem cells in animal models. …
Metadata
Title
Chimeric maternal cells as T lymphocyte targets in pediatric SLE
Authors
Anne M Stevens
Matthew Crabtree
Gretchen Henstorf
J Lee Nelson
Publication date
01-07-2012
Publisher
BioMed Central
Published in
Pediatric Rheumatology / Issue Special Issue 1/2012
Electronic ISSN: 1546-0096
DOI
https://doi.org/10.1186/1546-0096-10-S1-A4

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