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Open Access 01-07-2012 | Poster presentation

The primary complement components contained in circulating immune complexes in oligoarticular and polyarticular juvenile idiopathic arthritis patient sera are C1q and C4: evidence of classical complement activation

Authors: Brooke E Gilliam, Melinda R Reed, Anil K Chauhan, Amanda Dehlendorf, Sandra Crespo-Pagnussat, Terry L Moore

Published in: Pediatric Rheumatology | Special Issue 1/2012

Excerpt

Circulating immune complexes (CICs) from juvenile idiopathic arthritis (JIA) sera have been shown to contain bound complement components; however, whether the classical or alternative pathway is the main pathway involved remains undetermined. To delineate the role of these pathways in the disease process, we measured activated complement products bound to CICs in sera from 100 JIA patients. …

Title: The primary complement components contained in circulating immune complexes in oligoarticular and polyarticular juvenile idiopathic arthritis patient sera are C1q and C4: evidence of classical complement activation
Authors: Brooke E Gilliam
Melinda R Reed
Anil K Chauhan
Amanda Dehlendorf
Sandra Crespo-Pagnussat
Terry L Moore
Publication date: 01-07-2012
Publisher: BioMed Central
Published in: Pediatric Rheumatology / Issue Special Issue 1/2012
Electronic ISSN: 1546-0096
DOI: https://doi.org/10.1186/1546-0096-10-S1-A120

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The primary complement components contained in circulating immune complexes in oligoarticular and polyarticular juvenile idiopathic arthritis patient sera are C1q and C4: evidence of classical complement activation

Excerpt

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