Published in:
Open Access
01-12-2011 | Poster presentation
Degree of diffuse fibrosis measured by MRI correlates with LV remodelling in childhood cancer survivors after anthracycline chemotherapy
Authors:
Edythe B Tham, Kelvin Chow, Maria Spavor, Joseph J Pagano, Mark Haykowsky, Richard Thompson
Published in:
Journal of Cardiovascular Magnetic Resonance
|
Special Issue 1/2011
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Excerpt
The effectiveness of anthracycline chemotherapy is limited by dose dependant cardiotoxicity. Current protocols reduce the cumulative dose, however subclinical myocardial damage may still manifest years after cessation of therapy. The most serious side effect is dilated cardiomyopathy with pathological changes of fibrosis. The potential presence of fibrosis in this remodelling is unknown. …