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Published in: Cost Effectiveness and Resource Allocation 1/2014

Open Access 01-12-2014 | Research

Cost-effectiveness of eye care services in Zambia

Authors: Ulla K Griffiths, Fiammetta M Bozzani, Adrian Gheorghe, Lawrence Mwenge, Clare Gilbert

Published in: Cost Effectiveness and Resource Allocation | Issue 1/2014

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Abstract

Objective

To estimate the cost-effectiveness of cataract surgery and refractive error/presbyopia correction in Zambia.

Methods

Primary data on costs and health related quality of life were collected in a prospective cohort study of 170 cataract and 113 refractive error/presbyopia patients recruited from three health facilities. Six months later, follow-up data were available from 77 and 41 patients who had received cataract surgery and spectacles, respectively. Costs were determined from patient interviews and micro-costing at the three health facilities. Utility values were gathered by administering the EQ-5D quality of life instrument immediately before and six months after cataract surgery or acquiring spectacles. A probabilistic state-transition model was used to generate cost-effectiveness estimates with uncertainty ranges.

Results

Utility values significantly improved across the patient sample after cataract surgery and acquiring spectacles. Incremental costs per Quality Adjusted Life Years gained were US$ 259 for cataract surgery and US$ 375 for refractive error correction. The probabilities of the incremental cost-effectiveness ratios being below the Zambian gross national income per capita were 95% for both cataract surgery and refractive error correction.

Conclusion

In spite of proven cost-effectiveness, severe health system constraints are likely to hamper scaling up of the interventions.
Appendix
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Literature
1.
go back to reference Pascolini D, Mariotti SP: Global estimates of visual impairment: 2010. Br J Ophthalmol 2012, 96: 614–618. 10.1136/bjophthalmol-2011-300539PubMedCrossRef Pascolini D, Mariotti SP: Global estimates of visual impairment: 2010. Br J Ophthalmol 2012, 96: 614–618. 10.1136/bjophthalmol-2011-300539PubMedCrossRef
2.
go back to reference Lindfield R, Griffiths U, Bozzani F, Mumba M, Munsanje J: A rapid assessment of avoidable blindness in Southern Zambia. PLoS One 2012, 7: e38483. 10.1371/journal.pone.0038483PubMedCentralPubMedCrossRef Lindfield R, Griffiths U, Bozzani F, Mumba M, Munsanje J: A rapid assessment of avoidable blindness in Southern Zambia. PLoS One 2012, 7: e38483. 10.1371/journal.pone.0038483PubMedCentralPubMedCrossRef
3.
go back to reference Bozzani FM, Griffiths UK, Blanchet K, Schmidt E: Health systems analysis of eye care services in Zambia: evaluating progress towards VISION 2020 goals. BMC Health Serv Res 2014, 14: 94. DOI:10.1186/1472–6963–14–94 10.1186/1472-6963-14-94PubMedCentralPubMedCrossRef Bozzani FM, Griffiths UK, Blanchet K, Schmidt E: Health systems analysis of eye care services in Zambia: evaluating progress towards VISION 2020 goals. BMC Health Serv Res 2014, 14: 94. DOI:10.1186/1472–6963–14–94 10.1186/1472-6963-14-94PubMedCentralPubMedCrossRef
5.
go back to reference Griffiths UK, Dieye Y, Fleming J, Hajjeh R, Edmond K: Costs of meningitis sequelae in children in Dakar, Senegal. Pediatr Infect Dis J 2012, 31: e189-e195. 10.1097/INF.0b013e3182615297PubMedCrossRef Griffiths UK, Dieye Y, Fleming J, Hajjeh R, Edmond K: Costs of meningitis sequelae in children in Dakar, Senegal. Pediatr Infect Dis J 2012, 31: e189-e195. 10.1097/INF.0b013e3182615297PubMedCrossRef
6.
go back to reference Griffiths UK, Bozzani F, Muleya L, Mumba M: Costs of eye care services: prospective study from a faith-based hospital in Zambia. Ophthalmic Epidemiol 2013. Oct 4. [Epub ahead of print] Griffiths UK, Bozzani F, Muleya L, Mumba M: Costs of eye care services: prospective study from a faith-based hospital in Zambia. Ophthalmic Epidemiol 2013. Oct 4. [Epub ahead of print]
7.
go back to reference Polack S, Eusebio C, Mathenge W, Wadud Z, Mamunur AKM, Fletcher A, Foster A, Kuper H: The impact of cataract surgery on health related quality of life in Kenya, the Philippines and Bangladesh. Ophthalmic Epidemiol 2010, 17: 387–399. 10.3109/09286586.2010.528136PubMedCrossRef Polack S, Eusebio C, Mathenge W, Wadud Z, Mamunur AKM, Fletcher A, Foster A, Kuper H: The impact of cataract surgery on health related quality of life in Kenya, the Philippines and Bangladesh. Ophthalmic Epidemiol 2010, 17: 387–399. 10.3109/09286586.2010.528136PubMedCrossRef
8.
go back to reference Laviers HR, Omar F, Jecha H, Kassim G, Gilbert C: Presbyopic spectacle coverage, willingness to pay for near correction, and the impact of correcting uncorrected presbyopia in adults in Zanzibar, East Africa. Invest Ophthalmol Vis Sci 2010, 51: 1234–1241. 10.1167/iovs.08-3154PubMedCrossRef Laviers HR, Omar F, Jecha H, Kassim G, Gilbert C: Presbyopic spectacle coverage, willingness to pay for near correction, and the impact of correcting uncorrected presbyopia in adults in Zanzibar, East Africa. Invest Ophthalmol Vis Sci 2010, 51: 1234–1241. 10.1167/iovs.08-3154PubMedCrossRef
9.
go back to reference Schulze-Bonsel K, Feltgen N, Burau H, Hansen L, Bach M: Visual acuities “hand motion” and “counting fingers” can be quantified with the freiburg visual acuity test. Invest Ophthalmol Vis Sci 2006, 47: 1236–1240. 10.1167/iovs.05-0981PubMedCrossRef Schulze-Bonsel K, Feltgen N, Burau H, Hansen L, Bach M: Visual acuities “hand motion” and “counting fingers” can be quantified with the freiburg visual acuity test. Invest Ophthalmol Vis Sci 2006, 47: 1236–1240. 10.1167/iovs.05-0981PubMedCrossRef
10.
go back to reference The EuroQol group: EuroQol–a new facility for the measurement of health-related quality of life. Health Policy 1990, 16: 199–208.CrossRef The EuroQol group: EuroQol–a new facility for the measurement of health-related quality of life. Health Policy 1990, 16: 199–208.CrossRef
11.
go back to reference Rabin R, de Charro F: EQ-5D: a measure of health status from the EuroQol Group. Ann Med 2001, 33: 337–343. 10.3109/07853890109002087PubMedCrossRef Rabin R, de Charro F: EQ-5D: a measure of health status from the EuroQol Group. Ann Med 2001, 33: 337–343. 10.3109/07853890109002087PubMedCrossRef
13.
14.
go back to reference Imam AU, Gilbert CE, Sivasubramaniam S, Murthy GV, Maini R, Rabiu MM, Nigeria National B, Visual Impairment Study G: Outcome of cataract surgery in Nigeria: visual acuity, autorefraction, and optimal intraocular lens powers–results from the Nigeria national survey. Ophthalmology 2011, 118: 719–724. 10.1016/j.ophtha.2010.08.025PubMedCrossRef Imam AU, Gilbert CE, Sivasubramaniam S, Murthy GV, Maini R, Rabiu MM, Nigeria National B, Visual Impairment Study G: Outcome of cataract surgery in Nigeria: visual acuity, autorefraction, and optimal intraocular lens powers–results from the Nigeria national survey. Ophthalmology 2011, 118: 719–724. 10.1016/j.ophtha.2010.08.025PubMedCrossRef
15.
go back to reference Lundstrom M, Wendel E: Duration of self assessed benefit of cataract extraction: a long term study. Br J Ophthalmol 2005, 89: 1017–1020. 10.1136/bjo.2005.065961PubMedCentralPubMedCrossRef Lundstrom M, Wendel E: Duration of self assessed benefit of cataract extraction: a long term study. Br J Ophthalmol 2005, 89: 1017–1020. 10.1136/bjo.2005.065961PubMedCentralPubMedCrossRef
18.
go back to reference Briggs A, Gray A: The distribution of health care costs and their statistical analysis for economic evaluation. J Health Serv Res Policy 1998, 3: 233–245.PubMed Briggs A, Gray A: The distribution of health care costs and their statistical analysis for economic evaluation. J Health Serv Res Policy 1998, 3: 233–245.PubMed
21.
go back to reference Walters SJ, Brazier JE: Comparison of the minimally important difference for two health state utility measures: EQ-5D and SF-6D. Qual Life Res 2005, 14: 1523–1532. 10.1007/s11136-004-7713-0PubMedCrossRef Walters SJ, Brazier JE: Comparison of the minimally important difference for two health state utility measures: EQ-5D and SF-6D. Qual Life Res 2005, 14: 1523–1532. 10.1007/s11136-004-7713-0PubMedCrossRef
22.
go back to reference Nichols BE, Boucher CAB, van Dijk JH, Thuma PE, Nouwen JL, Baltussen R, van de Wijgert J, Sloot PMA, van de Vijver DAMC: Cost-effectiveness of Pre-Exposure Prophylaxis (PrEP) in preventing HIV-1 infections in rural Zambia: a modeling study. PLoS ONE 2013, 8: e59549. 10.1371/journal.pone.0059549PubMedCentralPubMedCrossRef Nichols BE, Boucher CAB, van Dijk JH, Thuma PE, Nouwen JL, Baltussen R, van de Wijgert J, Sloot PMA, van de Vijver DAMC: Cost-effectiveness of Pre-Exposure Prophylaxis (PrEP) in preventing HIV-1 infections in rural Zambia: a modeling study. PLoS ONE 2013, 8: e59549. 10.1371/journal.pone.0059549PubMedCentralPubMedCrossRef
23.
go back to reference Mairin R, Griffin S, Chitah B, Walker S, Mulenga V, Kalolo D, Hawkins N, Concepta M, Michael B, Chintu C, Sculpher MJ, Gibb DM: The cost-effectiveness of cotrimoxazole prophylaxis in HIV-infected children in Zambia. AIDS 2008, 22: 749–757. 10.1097/QAD.0b013e3282f43519CrossRef Mairin R, Griffin S, Chitah B, Walker S, Mulenga V, Kalolo D, Hawkins N, Concepta M, Michael B, Chintu C, Sculpher MJ, Gibb DM: The cost-effectiveness of cotrimoxazole prophylaxis in HIV-infected children in Zambia. AIDS 2008, 22: 749–757. 10.1097/QAD.0b013e3282f43519CrossRef
24.
go back to reference Maclean C, Stringer J: Potential cost-effectiveness of maternal and infant antiretroviral interventions to prevent mother-to-child transmission during breast-feeding. J Acquir Immune Defic Syndr 2005, 38: 570–577. 10.1097/01.qai.0000142919.51570.88PubMedCrossRef Maclean C, Stringer J: Potential cost-effectiveness of maternal and infant antiretroviral interventions to prevent mother-to-child transmission during breast-feeding. J Acquir Immune Defic Syndr 2005, 38: 570–577. 10.1097/01.qai.0000142919.51570.88PubMedCrossRef
25.
go back to reference Tengs TO, Lin TH: A meta-analysis of utility estimates for HIV/AIDS. Med Decis Mak 2002, 22: 475–481. 10.1177/0272989X02238300CrossRef Tengs TO, Lin TH: A meta-analysis of utility estimates for HIV/AIDS. Med Decis Mak 2002, 22: 475–481. 10.1177/0272989X02238300CrossRef
26.
go back to reference Tosh J, Brazier J, Evans P, Longworth L: A review of generic preference-based measures of health-related quality of life in visual disorders. Value Health 2012, 15: 118–127. 10.1016/j.jval.2011.08.002PubMedCentralPubMedCrossRef Tosh J, Brazier J, Evans P, Longworth L: A review of generic preference-based measures of health-related quality of life in visual disorders. Value Health 2012, 15: 118–127. 10.1016/j.jval.2011.08.002PubMedCentralPubMedCrossRef
27.
go back to reference Bozzani FM, Alavi Y, Jofre-Bonet M, Kuper H: A comparison of the sensitivity of EQ-5D, SF-6D and TTO utility values to changes in vision and perceived visual function in patients with primary open-angle glaucoma. BMC Ophthalmol 2012, 12: 43. 10.1186/1471-2415-12-43PubMedCentralPubMedCrossRef Bozzani FM, Alavi Y, Jofre-Bonet M, Kuper H: A comparison of the sensitivity of EQ-5D, SF-6D and TTO utility values to changes in vision and perceived visual function in patients with primary open-angle glaucoma. BMC Ophthalmol 2012, 12: 43. 10.1186/1471-2415-12-43PubMedCentralPubMedCrossRef
28.
go back to reference Abubakar T, Gudlavalleti MV, Sivasubramaniam S, Gilbert CE, Abdull MM, Imam AU: Coverage of hospital-based cataract surgery and barriers to the uptake of surgery among cataract blind persons in nigeria: the Nigeria National Blindness and Visual Impairment Survey. Ophthalmic Epidemiol 2012, 19: 58–66. 10.3109/09286586.2011.643271PubMedCrossRef Abubakar T, Gudlavalleti MV, Sivasubramaniam S, Gilbert CE, Abdull MM, Imam AU: Coverage of hospital-based cataract surgery and barriers to the uptake of surgery among cataract blind persons in nigeria: the Nigeria National Blindness and Visual Impairment Survey. Ophthalmic Epidemiol 2012, 19: 58–66. 10.3109/09286586.2011.643271PubMedCrossRef
29.
go back to reference Janssen MF, Pickard AS, Golicki D, Gudex C, Niewada M, Scalone L, Swinburn P, Busschbach J: Measurement properties of the EQ-5D-5L compared to the EQ-5D-3L across eight patient groups: a multi-country study. Qual Life Res 2013,22(7):1717–1727. 10.1007/s11136-012-0322-4PubMedCentralPubMedCrossRef Janssen MF, Pickard AS, Golicki D, Gudex C, Niewada M, Scalone L, Swinburn P, Busschbach J: Measurement properties of the EQ-5D-5L compared to the EQ-5D-3L across eight patient groups: a multi-country study. Qual Life Res 2013,22(7):1717–1727. 10.1007/s11136-012-0322-4PubMedCentralPubMedCrossRef
30.
go back to reference Scalone L, Ciampichini R, Fagiuoli S, Gardini I, Fusco F, Gaeta L, Del Prete A, Cesana G, Mantovani L: Comparing the performance of the standard EQ-5D 3L with the new version EQ-5D 5L in patients with chronic hepatic diseases. Qual Life Res 2013,22(7):1707–1716. 10.1007/s11136-012-0318-0PubMedCrossRef Scalone L, Ciampichini R, Fagiuoli S, Gardini I, Fusco F, Gaeta L, Del Prete A, Cesana G, Mantovani L: Comparing the performance of the standard EQ-5D 3L with the new version EQ-5D 5L in patients with chronic hepatic diseases. Qual Life Res 2013,22(7):1707–1716. 10.1007/s11136-012-0318-0PubMedCrossRef
31.
go back to reference Lansingh VC, Carter MJ, Martens M: Global cost-effectiveness of cataract surgery. Ophthalmology 2007, 114: 1670–1678. 10.1016/j.ophtha.2006.12.013PubMedCrossRef Lansingh VC, Carter MJ, Martens M: Global cost-effectiveness of cataract surgery. Ophthalmology 2007, 114: 1670–1678. 10.1016/j.ophtha.2006.12.013PubMedCrossRef
32.
go back to reference Eye Care Comparative Effectiveness Research Team (ECCERT): Cost-utility analysis of cataract surgery in Japan: a probabilistic Markov modeling study. Jpn J Ophthalmol 2013,57(4):391–401.CrossRef Eye Care Comparative Effectiveness Research Team (ECCERT): Cost-utility analysis of cataract surgery in Japan: a probabilistic Markov modeling study. Jpn J Ophthalmol 2013,57(4):391–401.CrossRef
33.
go back to reference Sach TH, Foss AJE, Gregson RM, Zaman A, Osborn F, Masud T, Harwood RH: Second-eye cataract surgery in elderly women: a cost-utility analysis conducted alongside a randomized controlled trial. Eye 2010, 24: 276–283. 10.1038/eye.2009.112PubMedCrossRef Sach TH, Foss AJE, Gregson RM, Zaman A, Osborn F, Masud T, Harwood RH: Second-eye cataract surgery in elderly women: a cost-utility analysis conducted alongside a randomized controlled trial. Eye 2010, 24: 276–283. 10.1038/eye.2009.112PubMedCrossRef
34.
go back to reference Lewallen S, Geneau R, Mahande M, Msangi J, Nyaupumbwe S, Kitumba R: Willingness to pay for cataract surgery in two regions of Tanzania. Br J Ophthalmol 2006, 90: 11–13. 10.1136/bjo.2005.079715PubMedCentralPubMedCrossRef Lewallen S, Geneau R, Mahande M, Msangi J, Nyaupumbwe S, Kitumba R: Willingness to pay for cataract surgery in two regions of Tanzania. Br J Ophthalmol 2006, 90: 11–13. 10.1136/bjo.2005.079715PubMedCentralPubMedCrossRef
35.
go back to reference Busbee B, Brown M, Brown G, Sharma S: Incremental cost-effectiveness of initial cataract surgery. Ophthalmology 2002, 109: 606–612. 10.1016/S0161-6420(01)00971-XPubMedCrossRef Busbee B, Brown M, Brown G, Sharma S: Incremental cost-effectiveness of initial cataract surgery. Ophthalmology 2002, 109: 606–612. 10.1016/S0161-6420(01)00971-XPubMedCrossRef
36.
go back to reference Kobelt G, Lundstrom M, Stenevi U: Cost-effectiveness of cataract surgery. Method to assess cost-effectiveness using registry data. J Cataract Refract Surg 2002, 28: 1742–1749. 10.1016/S0886-3350(02)01220-8PubMedCrossRef Kobelt G, Lundstrom M, Stenevi U: Cost-effectiveness of cataract surgery. Method to assess cost-effectiveness using registry data. J Cataract Refract Surg 2002, 28: 1742–1749. 10.1016/S0886-3350(02)01220-8PubMedCrossRef
37.
go back to reference Frick KD, Riva-Clement L, Shankar MB: Screening for refractive error and fitting with spectacles in rural and urban India: cost-effectiveness. Ophthalmic Epidemiol 2009, 16: 378–387. 10.3109/09286580903312277PubMedCrossRef Frick KD, Riva-Clement L, Shankar MB: Screening for refractive error and fitting with spectacles in rural and urban India: cost-effectiveness. Ophthalmic Epidemiol 2009, 16: 378–387. 10.3109/09286580903312277PubMedCrossRef
38.
go back to reference Lester BA: Comparing the cost-effectiveness of school eye screening versus a primary eye care model to provide refractive error services for children in India. Community Eye Health 2007, 20: 15.PubMedCentralPubMed Lester BA: Comparing the cost-effectiveness of school eye screening versus a primary eye care model to provide refractive error services for children in India. Community Eye Health 2007, 20: 15.PubMedCentralPubMed
39.
go back to reference Tahhan N, Papas E, Fricke TR, Frick KD, Holden BA: Utility and uncorrected refractive error. Ophthalmology 2013,120(9):1736–1744. 10.1016/j.ophtha.2013.02.014PubMedCrossRef Tahhan N, Papas E, Fricke TR, Frick KD, Holden BA: Utility and uncorrected refractive error. Ophthalmology 2013,120(9):1736–1744. 10.1016/j.ophtha.2013.02.014PubMedCrossRef
40.
go back to reference Fattore G, Torbica A: Cost and reimbursement of cataract surgery in Europe: a cross-country comparison. Health Econ 2008, 17: S71-S82. 10.1002/hec.1324PubMedCrossRef Fattore G, Torbica A: Cost and reimbursement of cataract surgery in Europe: a cross-country comparison. Health Econ 2008, 17: S71-S82. 10.1002/hec.1324PubMedCrossRef
41.
go back to reference Sach TH, Foss AJE, Gregson RM, Zaman A, Osborn F, Masud T, Harwood RH: Falls and health status in elderly women following first eye cataract surgery: an economic evaluation conducted alongside a randomised controlled trial. Br J Ophthalmol 2007, 91: 1675–1679. 10.1136/bjo.2007.118687PubMedCentralPubMedCrossRef Sach TH, Foss AJE, Gregson RM, Zaman A, Osborn F, Masud T, Harwood RH: Falls and health status in elderly women following first eye cataract surgery: an economic evaluation conducted alongside a randomised controlled trial. Br J Ophthalmol 2007, 91: 1675–1679. 10.1136/bjo.2007.118687PubMedCentralPubMedCrossRef
42.
go back to reference Lafuma A, Berdeaux G: Modelling lifetime cost consequences of ReSTOR(R) in cataract surgery in four European countries. BMC Ophthalmol 2008, 8: 12. 10.1186/1471-2415-8-12PubMedCentralPubMedCrossRef Lafuma A, Berdeaux G: Modelling lifetime cost consequences of ReSTOR(R) in cataract surgery in four European countries. BMC Ophthalmol 2008, 8: 12. 10.1186/1471-2415-8-12PubMedCentralPubMedCrossRef
Metadata
Title
Cost-effectiveness of eye care services in Zambia
Authors
Ulla K Griffiths
Fiammetta M Bozzani
Adrian Gheorghe
Lawrence Mwenge
Clare Gilbert
Publication date
01-12-2014
Publisher
BioMed Central
Published in
Cost Effectiveness and Resource Allocation / Issue 1/2014
Electronic ISSN: 1478-7547
DOI
https://doi.org/10.1186/1478-7547-12-6

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