Skip to main content
Top
Published in: Human Resources for Health 1/2012

Open Access 01-12-2012 | Research

Human resources needs for universal access to antiretroviral therapy in South Africa: a time and motion study

Authors: Jan AC Hontelez, Marie-Louise Newell, Ruth M Bland, Kristen Munnelly, Richard J Lessells, Till Bärnighausen

Published in: Human Resources for Health | Issue 1/2012

Login to get access

Abstract

Background

Although access to life-saving treatment for patients infected with HIV in South Africa has improved substantially since 2004, treating all eligible patients (universal access) remains elusive. As the prices of antiretroviral drugs have dropped over the past years, availability of human resources may now be the most important barrier to achieving universal access to HIV treatment in Africa. We quantify the number of HIV health workers (HHWs) required to be added to the current HIV workforce to achieve universal access to HIV treatment in South Africa, under different eligibility criteria.

Methods

We performed a time and motion study in three HIV clinics in a rural, primary care-based HIV treatment program in KwaZulu-Natal, South Africa, to estimate the average time per patient visit for doctors, nurses, and counselors. We estimated the additional number of HHWs needed to achieve universal access to HIV treatment within one year.

Results

For universal access to HIV treatment for all patients with a CD4 cell count of ≤350 cells/μl, an additional 2,200 nurses, 3,800 counselors, and 300 doctors would be required, at additional annual salary cost of 929 million South African rand (ZAR), equivalent to US$ 141 million. For universal treatment (‘treatment as prevention’), an additional 6,000 nurses, 11,000 counselors, and 800 doctors would be required, at an additional annual salary cost of ZAR 2.6 billion (US$ 400 million).

Conclusions

Universal access to HIV treatment for patients with a CD4 cell count of ≤350 cells/μl in South Africa may be affordable, but the number of HHWs available for HIV treatment will need to be substantially increased. Treatment as prevention strategies will require considerable additional financial and human resources commitments.
Literature
2.
go back to reference Mills EJ, Bakanda C, Birungi J, Mwesigwa R, Chan K, Ford N, Hogg RS, Cooper C: Mortality by baseline CD4 cell count among HIV patients initiating antiretroviral therapy: evidence from a large cohort in Uganda. AIDS. 2011, 25: 851-855. 10.1097/QAD.0b013e32834564e9.CrossRefPubMed Mills EJ, Bakanda C, Birungi J, Mwesigwa R, Chan K, Ford N, Hogg RS, Cooper C: Mortality by baseline CD4 cell count among HIV patients initiating antiretroviral therapy: evidence from a large cohort in Uganda. AIDS. 2011, 25: 851-855. 10.1097/QAD.0b013e32834564e9.CrossRefPubMed
3.
go back to reference Sterne JA, May M, Costagliola D, de Wolf F, Phillips AN, Harris R, Funk MJ, Geskus RB, Gill J, Dabis F, Miro JM, Justice AC, Ledergerber B, Fatkenheuer G, Hogg RS, Monforte AD, Saag M, Smith C, Staszewski S, Egger M, Cole SR: Timing of initiation of antiretroviral therapy in AIDS-free HIV-1-infected patients: a collaborative analysis of 18 HIV cohort studies. Lancet. 2009, 373: 1352-1363.CrossRefPubMed Sterne JA, May M, Costagliola D, de Wolf F, Phillips AN, Harris R, Funk MJ, Geskus RB, Gill J, Dabis F, Miro JM, Justice AC, Ledergerber B, Fatkenheuer G, Hogg RS, Monforte AD, Saag M, Smith C, Staszewski S, Egger M, Cole SR: Timing of initiation of antiretroviral therapy in AIDS-free HIV-1-infected patients: a collaborative analysis of 18 HIV cohort studies. Lancet. 2009, 373: 1352-1363.CrossRefPubMed
4.
go back to reference Walensky RP, Wolf LL, Wood R, Fofana MO, Freedberg KA, Martinson NA, Paltiel AD, Anglaret X, Weinstein MC, Losina E: When to start antiretroviral therapy in resource-limited settings. Ann Intern Med. 2009, 151: 157-166.CrossRefPubMedPubMedCentral Walensky RP, Wolf LL, Wood R, Fofana MO, Freedberg KA, Martinson NA, Paltiel AD, Anglaret X, Weinstein MC, Losina E: When to start antiretroviral therapy in resource-limited settings. Ann Intern Med. 2009, 151: 157-166.CrossRefPubMedPubMedCentral
8.
go back to reference Chen L, Evans T, Anand S, Boufford JI, Brown H, Chowdhury M, Cueto M, Dare L, Dussault G, Elzinga G, Fee E, Habte D, Hanvoravongchai P, Jacobs M, Kurowski C, Michael S, Pablos-Mendez A, Sewankambo N, Solimano G, Stilwell B, de Waal A, Wibulpolprasert S: Human resources for health: overcoming the crisis. Lancet. 2004, 364: 1984-1990. 10.1016/S0140-6736(04)17482-5.CrossRefPubMed Chen L, Evans T, Anand S, Boufford JI, Brown H, Chowdhury M, Cueto M, Dare L, Dussault G, Elzinga G, Fee E, Habte D, Hanvoravongchai P, Jacobs M, Kurowski C, Michael S, Pablos-Mendez A, Sewankambo N, Solimano G, Stilwell B, de Waal A, Wibulpolprasert S: Human resources for health: overcoming the crisis. Lancet. 2004, 364: 1984-1990. 10.1016/S0140-6736(04)17482-5.CrossRefPubMed
9.
go back to reference Chen L, Hanvoravongchai P: HIV/AIDS and human resources. Bull World Health Organ. 2005, 83: 242- Chen L, Hanvoravongchai P: HIV/AIDS and human resources. Bull World Health Organ. 2005, 83: 242-
10.
go back to reference Van Damme W, Kober K, Kegels G: Scaling-up antiretroviral treatment in Southern African countries with human resource shortage: how will health systems adapt?. Soc Sci Med. 2008, 66: 2108-2121. 10.1016/j.socscimed.2008.01.043.CrossRefPubMed Van Damme W, Kober K, Kegels G: Scaling-up antiretroviral treatment in Southern African countries with human resource shortage: how will health systems adapt?. Soc Sci Med. 2008, 66: 2108-2121. 10.1016/j.socscimed.2008.01.043.CrossRefPubMed
12.
go back to reference Hontelez JA, de Vlas SJ, Tanser F, Bakker R, Bärnighausen T, Newell ML, Baltussen R, Lurie MN: The impact of the new WHO antiretroviral treatment guidelines on HIV epidemic dynamics and cost in South Africa. PLoS One. 2011, 6: e21919-10.1371/journal.pone.0021919.CrossRefPubMedPubMedCentral Hontelez JA, de Vlas SJ, Tanser F, Bakker R, Bärnighausen T, Newell ML, Baltussen R, Lurie MN: The impact of the new WHO antiretroviral treatment guidelines on HIV epidemic dynamics and cost in South Africa. PLoS One. 2011, 6: e21919-10.1371/journal.pone.0021919.CrossRefPubMedPubMedCentral
15.
go back to reference Dodd PJ, Garnett GP, Hallett TB: Examining the promise of HIV elimination by ‘test and treat’ in hyperendemic settings. AIDS. 2010, 24: 729-735. 10.1097/QAD.0b013e32833433fe.CrossRefPubMedPubMedCentral Dodd PJ, Garnett GP, Hallett TB: Examining the promise of HIV elimination by ‘test and treat’ in hyperendemic settings. AIDS. 2010, 24: 729-735. 10.1097/QAD.0b013e32833433fe.CrossRefPubMedPubMedCentral
16.
go back to reference Granich RM, Gilks CF, Dye C, De Cock KM, Williams BG: Universal voluntary HIV testing with immediate antiretroviral therapy as a strategy for elimination of HIV transmission: a mathematical model. Lancet. 2009, 373: 48-57. 10.1016/S0140-6736(08)61697-9.CrossRefPubMed Granich RM, Gilks CF, Dye C, De Cock KM, Williams BG: Universal voluntary HIV testing with immediate antiretroviral therapy as a strategy for elimination of HIV transmission: a mathematical model. Lancet. 2009, 373: 48-57. 10.1016/S0140-6736(08)61697-9.CrossRefPubMed
18.
go back to reference Sanne I, Orrell C, Fox MP, Conradie F, Ive P, Zeinecker J, Cornell M, Heiberg C, Ingram C, Panchia R, Rassool M, Gonin R, Stevens W, Truter H, Dehlinger M, van der Horst C, McIntyre J, Wood R: Nurse versus doctor management of HIV-infected patients receiving antiretroviral therapy (CIPRA-SA): a randomised non-inferiority trial. Lancet. 2010, 376: 33-40. 10.1016/S0140-6736(10)60894-X.CrossRefPubMedPubMedCentral Sanne I, Orrell C, Fox MP, Conradie F, Ive P, Zeinecker J, Cornell M, Heiberg C, Ingram C, Panchia R, Rassool M, Gonin R, Stevens W, Truter H, Dehlinger M, van der Horst C, McIntyre J, Wood R: Nurse versus doctor management of HIV-infected patients receiving antiretroviral therapy (CIPRA-SA): a randomised non-inferiority trial. Lancet. 2010, 376: 33-40. 10.1016/S0140-6736(10)60894-X.CrossRefPubMedPubMedCentral
19.
go back to reference Groover M: Work Systems: The Methods, Measurement & Management of Work. 2006, New Jersey: Prentice Hall Groover M: Work Systems: The Methods, Measurement & Management of Work. 2006, New Jersey: Prentice Hall
20.
go back to reference Houlihan CF, Bland R, Mutevedzi P, Lessells RJ, Ndirangu J, Thulare H, Newell M: Cohort Profile: Hlabisa HIV treatment and care programme. Int J Epidemiol. 2011, 40: 318-326. 10.1093/ije/dyp402.CrossRefPubMed Houlihan CF, Bland R, Mutevedzi P, Lessells RJ, Ndirangu J, Thulare H, Newell M: Cohort Profile: Hlabisa HIV treatment and care programme. Int J Epidemiol. 2011, 40: 318-326. 10.1093/ije/dyp402.CrossRefPubMed
21.
go back to reference Zaidi J, Grapsa K, Tanser M, Newell ML, Bärnighausen T: HIV prevalence trends after scale-up of antiretroviral treatment: a population-based study in a poor rural community in KwaZulu-Natal. Late-breaker oral presentation at IXX International AIDS Conference. 2012, USA: Washington DC, 22-27. Zaidi J, Grapsa K, Tanser M, Newell ML, Bärnighausen T: HIV prevalence trends after scale-up of antiretroviral treatment: a population-based study in a poor rural community in KwaZulu-Natal. Late-breaker oral presentation at IXX International AIDS Conference. 2012, USA: Washington DC, 22-27.
22.
go back to reference Cooke GS, Tanser FC, Bärnighausen T, Newell ML: Population uptake of antiretroviral treatment through primary care in rural South Africa. BMC Publ Health. 2010, 10: 585-10.1186/1471-2458-10-585.CrossRef Cooke GS, Tanser FC, Bärnighausen T, Newell ML: Population uptake of antiretroviral treatment through primary care in rural South Africa. BMC Publ Health. 2010, 10: 585-10.1186/1471-2458-10-585.CrossRef
23.
go back to reference WHO: Towards Universal Access: Scaling up Priority HIV/AIDS Interventions in the Health Sector; Progress Report 2010. 2010, Geneva: World Health Organization WHO: Towards Universal Access: Scaling up Priority HIV/AIDS Interventions in the Health Sector; Progress Report 2010. 2010, Geneva: World Health Organization
24.
go back to reference Health Systems Trust: National Antiretroviral Treatment Guidelines. 2004, uploads/files/sa_ART_Guidelines1.pdf, 1 Health Systems Trust: National Antiretroviral Treatment Guidelines. 2004, uploads/files/sa_ART_Guidelines1.pdf, 1
26.
go back to reference Kumaranayake L: The economics of scaling up: cost estimation for HIV/AIDS interventions. AIDS. 2008, 22 (Suppl 1): S23-33. 10.1097/01.aids.0000327620.47103.1d.CrossRefPubMed Kumaranayake L: The economics of scaling up: cost estimation for HIV/AIDS interventions. AIDS. 2008, 22 (Suppl 1): S23-33. 10.1097/01.aids.0000327620.47103.1d.CrossRefPubMed
27.
go back to reference Bärnighausen T, Salomon JA, Sangrujee N: HIV treatment as prevention: issues in economic evaluation. PLoS Med. 2012, 9: e1001263-10.1371/journal.pmed.1001263.CrossRefPubMedPubMedCentral Bärnighausen T, Salomon JA, Sangrujee N: HIV treatment as prevention: issues in economic evaluation. PLoS Med. 2012, 9: e1001263-10.1371/journal.pmed.1001263.CrossRefPubMedPubMedCentral
28.
go back to reference Meyer-Rath G, Over M: HIV treatment as prevention: modelling the cost of antiretroviral treatment–state of the art and future directions. PLoS Med. 2012, 9: e1001247-10.1371/journal.pmed.1001247.CrossRefPubMedPubMedCentral Meyer-Rath G, Over M: HIV treatment as prevention: modelling the cost of antiretroviral treatment–state of the art and future directions. PLoS Med. 2012, 9: e1001247-10.1371/journal.pmed.1001247.CrossRefPubMedPubMedCentral
29.
go back to reference Hirschhorn LR, Oguda L, Fullem A, Dreesch N, Wilson P: Estimating health workforce needs for antiretroviral therapy in resource-limited settings. Hum Resour Health. 2006, 4: 1-10.1186/1478-4491-4-1.CrossRefPubMedPubMedCentral Hirschhorn LR, Oguda L, Fullem A, Dreesch N, Wilson P: Estimating health workforce needs for antiretroviral therapy in resource-limited settings. Hum Resour Health. 2006, 4: 1-10.1186/1478-4491-4-1.CrossRefPubMedPubMedCentral
30.
go back to reference World Health Organization: Scaling Up HIV/AIDS Care: Service Delivery And Human Resources Perspectives. 2004, Geneva: World Health Organization World Health Organization: Scaling Up HIV/AIDS Care: Service Delivery And Human Resources Perspectives. 2004, Geneva: World Health Organization
31.
go back to reference Herbst AJ, Cooke GS, Bärnighausen T, KanyKany A, Tanser F, Newell ML: Adult mortality and antiretroviral treatment roll-out in rural KwaZulu-Natal, South Africa. Bull World Health Organ. 2009, 87: 754-762. 10.2471/BLT.08.058982.CrossRefPubMedPubMedCentral Herbst AJ, Cooke GS, Bärnighausen T, KanyKany A, Tanser F, Newell ML: Adult mortality and antiretroviral treatment roll-out in rural KwaZulu-Natal, South Africa. Bull World Health Organ. 2009, 87: 754-762. 10.2471/BLT.08.058982.CrossRefPubMedPubMedCentral
32.
go back to reference Mutevedzi PC, Lessells RJ, Heller T, Bärnighausen T, Cooke GS, Newell ML: Scale-up of a decentralized HIV treatment programme in rural KwaZulu-Natal, South Africa: does rapid expansion affect patient outcomes?. Bull World Health Organ. 2010, 88: 593-600. 10.2471/BLT.09.069419.CrossRefPubMedPubMedCentral Mutevedzi PC, Lessells RJ, Heller T, Bärnighausen T, Cooke GS, Newell ML: Scale-up of a decentralized HIV treatment programme in rural KwaZulu-Natal, South Africa: does rapid expansion affect patient outcomes?. Bull World Health Organ. 2010, 88: 593-600. 10.2471/BLT.09.069419.CrossRefPubMedPubMedCentral
33.
go back to reference Bor J, Herbst K, Newell M, Bärnighausen T: Dramatic increases in population life expectancy and the economic value of ART in rural South Africa. 2012, Washington DC, USA: IXX International AIDS Conference, 22-27. late-breaker oral presentation Bor J, Herbst K, Newell M, Bärnighausen T: Dramatic increases in population life expectancy and the economic value of ART in rural South Africa. 2012, Washington DC, USA: IXX International AIDS Conference, 22-27. late-breaker oral presentation
35.
go back to reference World Health Organization: Working Together for Health. 2006, Geneva: WHO World Health Organization: Working Together for Health. 2006, Geneva: WHO
36.
go back to reference Dayrit MM, Dolea C, Dreesch N: Addressing the human resources for health crisis in countries: How far have we gone? What can we expect to achieve by 2015?. Rev Peru Med Exp Salud Publica. 2011, 28: 327-336. 10.1590/S1726-46342011000200022.CrossRefPubMed Dayrit MM, Dolea C, Dreesch N: Addressing the human resources for health crisis in countries: How far have we gone? What can we expect to achieve by 2015?. Rev Peru Med Exp Salud Publica. 2011, 28: 327-336. 10.1590/S1726-46342011000200022.CrossRefPubMed
37.
go back to reference Bärnighausen T, Bloom D: The global health workforce. Oxford Handbook of Health Economics. Edited by: Glied S, Smith PC. 2011, Oxford: Oxford University Press Bärnighausen T, Bloom D: The global health workforce. Oxford Handbook of Health Economics. Edited by: Glied S, Smith PC. 2011, Oxford: Oxford University Press
38.
go back to reference Bärnighausen T, Bloom DE, Humair S: Universal antiretroviral treatment: the challenge of human resources. Bull World Health Organ. 2010, 88: 951-952. 10.2471/BLT.09.073890.CrossRefPubMedPubMedCentral Bärnighausen T, Bloom DE, Humair S: Universal antiretroviral treatment: the challenge of human resources. Bull World Health Organ. 2010, 88: 951-952. 10.2471/BLT.09.073890.CrossRefPubMedPubMedCentral
40.
go back to reference Robyn PJ, Sauerborn R, Bärnighausen T: Provider payment in community-based health insurance schemes in developing countries: a systematic review. Health Policy Plan. 2012, 10.1093/heapol/czs034. Epub ahead of print Apr 19, 2012 Robyn PJ, Sauerborn R, Bärnighausen T: Provider payment in community-based health insurance schemes in developing countries: a systematic review. Health Policy Plan. 2012, 10.1093/heapol/czs034. Epub ahead of print Apr 19, 2012
41.
go back to reference Dreesch N, Nyoni J, Mokopakgosi O, Seipone K, Kalilani JA, Kaluwa O, Musowe V: Public-private options for expanding access to human resources for HIV/AIDS in Botswana. Hum Resour Health. 2007, 5: 25-10.1186/1478-4491-5-25.CrossRefPubMedPubMedCentral Dreesch N, Nyoni J, Mokopakgosi O, Seipone K, Kalilani JA, Kaluwa O, Musowe V: Public-private options for expanding access to human resources for HIV/AIDS in Botswana. Hum Resour Health. 2007, 5: 25-10.1186/1478-4491-5-25.CrossRefPubMedPubMedCentral
42.
go back to reference Nigenda GH, Gonzalez LM: Contracting private sector providers for public sector health services in Jalisco. Mexico: perspectives of system actors. Hum Resour Health. 2009, 7: 79-10.1186/1478-4491-7-79.CrossRefPubMedPubMedCentral Nigenda GH, Gonzalez LM: Contracting private sector providers for public sector health services in Jalisco. Mexico: perspectives of system actors. Hum Resour Health. 2009, 7: 79-10.1186/1478-4491-7-79.CrossRefPubMedPubMedCentral
43.
go back to reference Petersen I, Lund C, Bhana A, Flisher AJ: A task shifting approach to primary mental health care for adults in South Africa: human resource requirements and costs for rural settings. Health Policy Plan. 2012, 27: 42-51. 10.1093/heapol/czr012.CrossRefPubMed Petersen I, Lund C, Bhana A, Flisher AJ: A task shifting approach to primary mental health care for adults in South Africa: human resource requirements and costs for rural settings. Health Policy Plan. 2012, 27: 42-51. 10.1093/heapol/czr012.CrossRefPubMed
44.
go back to reference Kawonga M, Blaauw D, Fonn S: Aligning vertical interventions to health systems: a case study of the HIV monitoring and evaluation system in South Africa. Health Res Policy Syst. 2012, 10: 2-10.1186/1478-4505-10-2.CrossRefPubMedPubMedCentral Kawonga M, Blaauw D, Fonn S: Aligning vertical interventions to health systems: a case study of the HIV monitoring and evaluation system in South Africa. Health Res Policy Syst. 2012, 10: 2-10.1186/1478-4505-10-2.CrossRefPubMedPubMedCentral
45.
go back to reference World Health Organization: Increasing Access to Health Workers in Remote and Rural Areas Through Improved Retention: Global Policy Recommendations. 2010, Geneva: WHO World Health Organization: Increasing Access to Health Workers in Remote and Rural Areas Through Improved Retention: Global Policy Recommendations. 2010, Geneva: WHO
46.
go back to reference Bärnighausen T, Bloom DE: Financial incentives for return of service in underserved areas: a systematic review. BMC Health Serv Res. 2009, 9: 86-10.1186/1472-6963-9-86.CrossRefPubMedPubMedCentral Bärnighausen T, Bloom DE: Financial incentives for return of service in underserved areas: a systematic review. BMC Health Serv Res. 2009, 9: 86-10.1186/1472-6963-9-86.CrossRefPubMedPubMedCentral
48.
go back to reference Bossert T, Bärnighausen T, Bowser D, Mitchell A: Assessing Financing, Education, Management and Policy Context for Strategic Planning of Human Resources in Health. 2007, Geneva: World Health Organization Bossert T, Bärnighausen T, Bowser D, Mitchell A: Assessing Financing, Education, Management and Policy Context for Strategic Planning of Human Resources in Health. 2007, Geneva: World Health Organization
49.
go back to reference UNAIDS: Manual for Costing HIV Facilities and Services. 2011, Geneva: UNAIDS UNAIDS: Manual for Costing HIV Facilities and Services. 2011, Geneva: UNAIDS
50.
go back to reference Bendavid E, Brandeau ML, Wood R, Owens DK: Comparative effectiveness of HIV testing and treatment in highly endemic regions. Arch Intern Med. 2010, 170: 1347-1354. 10.1001/archinternmed.2010.249.CrossRefPubMedPubMedCentral Bendavid E, Brandeau ML, Wood R, Owens DK: Comparative effectiveness of HIV testing and treatment in highly endemic regions. Arch Intern Med. 2010, 170: 1347-1354. 10.1001/archinternmed.2010.249.CrossRefPubMedPubMedCentral
51.
go back to reference Walensky RP, Paltiel AD, Losina E, Morris BL, Scott CA, Rhode ER, Seage GR, Freedberg KA: Test and treat DC: forecasting the impact of a comprehensive HIV strategy in Washington DC. Clin Infect Dis. 2010, 51: 392-400. 10.1086/655130.CrossRefPubMedPubMedCentral Walensky RP, Paltiel AD, Losina E, Morris BL, Scott CA, Rhode ER, Seage GR, Freedberg KA: Test and treat DC: forecasting the impact of a comprehensive HIV strategy in Washington DC. Clin Infect Dis. 2010, 51: 392-400. 10.1086/655130.CrossRefPubMedPubMedCentral
52.
go back to reference Dabis F, Newell ML, Hirschel B: HIV drugs for treatment, and for prevention. Lancet. 2010, 375: 2056-2057. 10.1016/S0140-6736(10)60838-0.CrossRefPubMed Dabis F, Newell ML, Hirschel B: HIV drugs for treatment, and for prevention. Lancet. 2010, 375: 2056-2057. 10.1016/S0140-6736(10)60838-0.CrossRefPubMed
53.
go back to reference Colvin CJ, Fairall L, Lewin S, Georgeu D, Zwarenstein M, Bachmann MO, Uebel KE, Bateman ED: Expanding access to ART in South Africa: the role of nurse-initiated treatment. S Afr Med J. 2010, 100: 210-212.CrossRefPubMed Colvin CJ, Fairall L, Lewin S, Georgeu D, Zwarenstein M, Bachmann MO, Uebel KE, Bateman ED: Expanding access to ART in South Africa: the role of nurse-initiated treatment. S Afr Med J. 2010, 100: 210-212.CrossRefPubMed
54.
go back to reference Cornell M, Grimsrud A, Fairall L, Fox MP, van Cutsem G, Giddy J, Wood R, Prozesky H, Mohapi L, Graber C, Egger M, Boulle A, Myer L: Temporal changes in programme outcomes among adult patients initiating antiretroviral therapy across South Africa, 2002–2007. AIDS. 2010, 24: 2263-2270. 10.1097/QAD.0b013e32833d45c5.CrossRefPubMedPubMedCentral Cornell M, Grimsrud A, Fairall L, Fox MP, van Cutsem G, Giddy J, Wood R, Prozesky H, Mohapi L, Graber C, Egger M, Boulle A, Myer L: Temporal changes in programme outcomes among adult patients initiating antiretroviral therapy across South Africa, 2002–2007. AIDS. 2010, 24: 2263-2270. 10.1097/QAD.0b013e32833d45c5.CrossRefPubMedPubMedCentral
55.
go back to reference Mayo E: The Human Problems of an Industrial Civilization. 1933, New York: MacMillan Mayo E: The Human Problems of an Industrial Civilization. 1933, New York: MacMillan
56.
go back to reference Parsons HM: What happened at Hawthorne? New evidence suggests the Hawthorne effect resulted from operant reinforcement contingencies. Science. 1974, 183: 922-932. 10.1126/science.183.4128.922.CrossRefPubMed Parsons HM: What happened at Hawthorne? New evidence suggests the Hawthorne effect resulted from operant reinforcement contingencies. Science. 1974, 183: 922-932. 10.1126/science.183.4128.922.CrossRefPubMed
57.
go back to reference Okorafor O: National health insurance reform in South Africa: estimating the implications for demand for private health insurance. Appl Health Econ Health Policy. 2012, 10: 189-200. 10.2165/11594830-000000000-00000.CrossRefPubMed Okorafor O: National health insurance reform in South Africa: estimating the implications for demand for private health insurance. Appl Health Econ Health Policy. 2012, 10: 189-200. 10.2165/11594830-000000000-00000.CrossRefPubMed
58.
go back to reference Bärnighausen T: Access to antiretroviral treatment in the developing world: a framework, review and health systems research agenda. Therapy. 2007, 4: 753-766. Bärnighausen T: Access to antiretroviral treatment in the developing world: a framework, review and health systems research agenda. Therapy. 2007, 4: 753-766.
59.
go back to reference Bärnighausen T, Bloom DE, Humair S: Human resources for treating HIV/AIDS: needs, capacities, and gaps. AIDS Patient Care STDS. 2007, 21: 799-812. 10.1089/apc.2007.0193.CrossRefPubMed Bärnighausen T, Bloom DE, Humair S: Human resources for treating HIV/AIDS: needs, capacities, and gaps. AIDS Patient Care STDS. 2007, 21: 799-812. 10.1089/apc.2007.0193.CrossRefPubMed
60.
go back to reference Attia S, Egger M, Muller M, Zwahlen M, Low N: Sexual transmission of HIV according to viral load and antiretroviral therapy: systematic review and meta-analysis. AIDS. 2009, 23: 1397-1404. 10.1097/QAD.0b013e32832b7dca.CrossRefPubMed Attia S, Egger M, Muller M, Zwahlen M, Low N: Sexual transmission of HIV according to viral load and antiretroviral therapy: systematic review and meta-analysis. AIDS. 2009, 23: 1397-1404. 10.1097/QAD.0b013e32832b7dca.CrossRefPubMed
61.
go back to reference Cohen MS, Chen YQ, McCauley M, Gamble T, Hosseinipour MC, Kumarasamy N, Hakim JG, Kumwenda J, Grinsztejn B, Pilotto JH, Godbole SV, Mehendale S, Chariyalertsak S, Santos BR, Mayer KH, Hoffman IF, Eshleman SH, Piwowar-Manning E, Wang L, Makhema J, Mills LA, de Bruyn G, Sanne I, Eron J, Gallant J, Havlir D, Swindells S, Ribaudo H, Elharrar V, Burns D: Prevention of HIV-1 infection with early antiretroviral therapy. N Engl J Med. 2011, 365: 493-505. 10.1056/NEJMoa1105243.CrossRefPubMedPubMedCentral Cohen MS, Chen YQ, McCauley M, Gamble T, Hosseinipour MC, Kumarasamy N, Hakim JG, Kumwenda J, Grinsztejn B, Pilotto JH, Godbole SV, Mehendale S, Chariyalertsak S, Santos BR, Mayer KH, Hoffman IF, Eshleman SH, Piwowar-Manning E, Wang L, Makhema J, Mills LA, de Bruyn G, Sanne I, Eron J, Gallant J, Havlir D, Swindells S, Ribaudo H, Elharrar V, Burns D: Prevention of HIV-1 infection with early antiretroviral therapy. N Engl J Med. 2011, 365: 493-505. 10.1056/NEJMoa1105243.CrossRefPubMedPubMedCentral
62.
go back to reference Donnell D, Baeten JM, Kiarie J, Thomas KK, Stevens W, Cohen CR, McIntyre J, Lingappa JR, Celum C: Heterosexual HIV-1 transmission after initiation of antiretroviral therapy: a prospective cohort analysis. Lancet. 2010, 375: 2092-2098. 10.1016/S0140-6736(10)60705-2.CrossRefPubMedPubMedCentral Donnell D, Baeten JM, Kiarie J, Thomas KK, Stevens W, Cohen CR, McIntyre J, Lingappa JR, Celum C: Heterosexual HIV-1 transmission after initiation of antiretroviral therapy: a prospective cohort analysis. Lancet. 2010, 375: 2092-2098. 10.1016/S0140-6736(10)60705-2.CrossRefPubMedPubMedCentral
63.
go back to reference Hontelez JA, Lurie MN, Newell ML, Bakker R, Tanser F, Bärnighausen T, Baltussen R, de Vlas SJ: Ageing with HIV in South Africa. AIDS. 2011, 25: 1665-1667. 10.1097/QAD.0b013e32834982ea.CrossRefPubMed Hontelez JA, Lurie MN, Newell ML, Bakker R, Tanser F, Bärnighausen T, Baltussen R, de Vlas SJ: Ageing with HIV in South Africa. AIDS. 2011, 25: 1665-1667. 10.1097/QAD.0b013e32834982ea.CrossRefPubMed
64.
go back to reference Hontelez J, de Vlas S, Baltussen R, Newell ML, Bakker R, Tanser F, Lurie M, Bärnighausen T: The impact of antiretroviral treatment on the age composition of the HIV epidemic in sub-Saharan Africa. AIDS. 2012, 26 (Suppl 1): S19-S30.CrossRefPubMed Hontelez J, de Vlas S, Baltussen R, Newell ML, Bakker R, Tanser F, Lurie M, Bärnighausen T: The impact of antiretroviral treatment on the age composition of the HIV epidemic in sub-Saharan Africa. AIDS. 2012, 26 (Suppl 1): S19-S30.CrossRefPubMed
65.
go back to reference Atun R, Bataringaya J: Building a durable response to HIV/AIDS: implications for health systems. J Acquir Immune Defic Syndr. 2011, 57 (Suppl 2): S91-95.CrossRefPubMed Atun R, Bataringaya J: Building a durable response to HIV/AIDS: implications for health systems. J Acquir Immune Defic Syndr. 2011, 57 (Suppl 2): S91-95.CrossRefPubMed
Metadata
Title
Human resources needs for universal access to antiretroviral therapy in South Africa: a time and motion study
Authors
Jan AC Hontelez
Marie-Louise Newell
Ruth M Bland
Kristen Munnelly
Richard J Lessells
Till Bärnighausen
Publication date
01-12-2012
Publisher
BioMed Central
Published in
Human Resources for Health / Issue 1/2012
Electronic ISSN: 1478-4491
DOI
https://doi.org/10.1186/1478-4491-10-39

Other articles of this Issue 1/2012

Human Resources for Health 1/2012 Go to the issue