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Reproductive Biology and Endocrinology
Published in: Reproductive Biology and Endocrinology 1/2014

Open Access 01-12-2014 | Research

The histidine-rich glycoprotein A1042G polymorphism and recurrent miscarriage: a pilot study

Authors: Evangelia Elenis, Karin E Lindgren, Helena Karypidis, Alkistis Skalkidou, Frida Hosseini, Katarina Bremme, Britt-Marie Landgren, Lottie Skjöldebrand-Sparre, Anneli Stavreus-Evers, Inger Sundström-Poromaa, Helena Åkerud

Published in: Reproductive Biology and Endocrinology | Issue 1/2014

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Abstract

Background

Histidine-rich Glycoprotein (HRG) has previously been shown to have an impact on implantation and fertility. The aim of this study was to investigate if there is an association between the HRG A1042G single nucleotide polymorphism (SNP) and recurrent miscarriage.

Methods

The study was designed as a case-control study and the women were included at University Hospitals in Sweden. 186 cases with recurrent miscarriage were compared with 380 pregnant controls with no history of miscarriage. Each woman was genotyped for the HRG A1042G SNP.

Results

The results indicated that the frequency of heterozygous HRG A1042G carriers was higher among controls compared to cases (34.7% vs 26.3%; p < 0.05). In a bivariate regression analysis, a negative association was found between recurrent miscarriage and heterozygous A/G carriers both in the entire study population (OR 0.67, 95% CI 0.45 - 0.99; p < 0.05) as well as in a subgroup of women with primary recurrent miscarriage (OR 0.37, 95% CI 0.16 - 0.84; p < 0.05). These results remained even after adjustment for known confounders such as age, BMI and thyroid disease (OR 0.36, 95% CI 0.15 - 0.84; p < 0.05).

Conclusions

Women who are heterozygous carriers of the HRG A1042G SNP suffer from recurrent miscarriage more seldom than homozygous carriers. Thus, analysis of the HRG A1042G SNP might be of importance for individual counseling regarding miscarriage.
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Metadata
Title
The histidine-rich glycoprotein A1042G polymorphism and recurrent miscarriage: a pilot study
Authors
Evangelia Elenis
Karin E Lindgren
Helena Karypidis
Alkistis Skalkidou
Frida Hosseini
Katarina Bremme
Britt-Marie Landgren
Lottie Skjöldebrand-Sparre
Anneli Stavreus-Evers
Inger Sundström-Poromaa
Helena Åkerud
Publication date
01-12-2014
Publisher
BioMed Central
Published in
Reproductive Biology and Endocrinology / Issue 1/2014
Electronic ISSN: 1477-7827
DOI
https://doi.org/10.1186/1477-7827-12-70

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