Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
Health and Quality of Life Outcomes
Published in: Health and Quality of Life Outcomes 1/2009

Open Access 01-12-2009 | Review

Measuring health-related quality of life in tuberculosis: a systematic review

Authors: Na Guo, Fawziah Marra, Carlo A Marra

Published in: Health and Quality of Life Outcomes | Issue 1/2009

Login to get access

Abstract

Introduction

Tuberculosis remains a major public health problem worldwide. In recent years, increasing efforts have been dedicated to assessing the health-related quality of life experienced by people infected with tuberculosis. The objectives of this study were to better understand the impact of tuberculosis and its treatment on people's quality of life, and to review quality of life instruments used in current tuberculosis research.

Methods

A systematic literature search from 1981 to 2008 was performed through a number of electronic databases as well as a manual search. Eligible studies assessed multi-dimensional quality of life in people with tuberculosis disease or infection using standardized instruments. Results of the included studies were summarized qualitatively.

Results

Twelve original studies met our criteria for inclusion. A wide range of quality of life instruments were involved, and the Short-Form 36 was most commonly used. A validated tuberculosis-specific quality of life instrument was not located. The findings showed that tuberculosis had a substantial and encompassing impact on patients' quality of life. Overall, the anti-tuberculosis treatment had a positive effect of improving patients' quality of life; their physical health tended to recover more quickly than the mental well-being. However, after the patients successfully completed treatment and were microbiologically 'cured', their quality of life remained significantly worse than the general population.

Conclusion

Tuberculosis has substantially adverse impacts on patients' quality of life, which persist after microbiological 'cure'. A variety of instruments were used to assess quality of life in tuberculosis and there has been no well-established tuberculosis-specific instrument, making it difficult to fully understand the impact of the illness.
Appendix
Available only for authorised users
Literature
1.
Guyatt GH, Feeny DH, Patrich DL: Measuring health-related quality of life. Ann Intern Med 1993, 118: 622–629.CrossRef
2.
Drummond MF, Sculpher MJ, Torrance GW, O'Brien BJ, Stoddart GL, (Eds): Methods for the economic evaluation of health care programmes. 3rd edition. Oxford University Press; 2005.
3.
Sherbourne CD, Sturm R, Wells KB: What outcomes matter to patients. J Gen Intern Med 1999, 14: 357–363. 10.1046/j.1525-1497.1999.00354.xCrossRef
4.
Patrick DL, Deyo RA: Generic and disease-specific measures in assessing health status and quality of life. Med Care 1989,27(Suppl 3):217–232. 10.1097/00005650-198903001-00018CrossRef
5.
Dye C, Scheele S, Dolin P, Pathania V, Raviglione MC: Consensus statement. Global burden of tuberculosis: estimated incidence, prevalence, and mortality by country. WHO Global Surveillance and Monitoring Project. JAMA 1999, 282: 677–686. 10.1001/jama.282.7.677CrossRef
6.
Blumberg HM, Burman WJ, Chaisson RE, Daley CL, Etkind SC, Friedman LN, Fujiwara P, Grzemska M, Hopewell PC, Iseman MD, Jasmer RM, Koppaka V, Menzies RI, O'Brien RJ, Reves RR, Reichman LB, Simone PM, Starke JR, Vernon AA: American Thoracic Society/Centers for Disease Control and Prevention/Infectious Diseases Society of America: treatment of tuberculosis. Am J Respir Crit Care Med 2003, 167: 603–662. 10.1164/rccm.167.4.603CrossRef
7.
Forget EJ, Menzies D: Adverse reactions to first-line antituberculosis drugs. Expert Opin Drug Saf 2006, 5: 231–249. 10.1517/14740338.5.2.231CrossRef
8.
Marra F, Marra CA, Bruchet N, Richardson K, Moadebi S, Elwood RK, FitzGerald JM: Adverse drug reactions associated with first-line anti-tuberculosis drug regimens. Int J Tuberc Lung Dis 2007, 11: 868–875.
9.
Liefooghe R, Michiels N, Habib S, Moran MB, De Muynck A: Perception and social consequences of tuberculosis: a focus group study of tuberculosis patients in Sialkot, Pakistan. Soc Sci Med 1995, 41: 1685–1692. 10.1016/0277-9536(95)00129-UCrossRef
10.
Kelly P: Isolation and stigma: the experience of patients with active tuberculosis. J Community Health Nurs 1999, 16: 233–241. 10.1207/S15327655JCHN1604_3CrossRef
11.
Long NH, Johansson E, Diwan VK, Winkvist A: Fear and social isolation as consequences of tuberculosis in VietNam: a gender analysis. Health Policy 2001, 58: 69–81. 10.1016/S0168-8510(01)00143-9CrossRef
12.
Macq J, Solis A, Martinez G, Martiny P, Dujardin B: An exploration of the social stigma of tuberculosis in five 'municipios' of Nicaragua to reflect on local interventions. Health Policy 2005, 74: 205–217. 10.1016/j.healthpol.2005.01.003CrossRef
13.
Hansel NN, Wu AW, Chang B, Diette GB: Quality of life in tuberculosis: Patient and provider perspectives. Qual Life Res 2004, 13: 639–652. 10.1023/B:QURE.0000021317.12945.f0CrossRef
14.
Marra CA, Marra F, Cox VC, Palepu A, Fitzgerald JM: Factors influencing quality of life in patients with active tuberculosis. Health Qual Life Outcomes 2004, 20: 58. 10.1186/1477-7525-2-58CrossRef
15.
Chang B, Wu AW, Hansel NN, Diette GB: Quality of life in tuberculosis: a review of the English language literature. Qual Life Res 2004, 13: 1633–1642. 10.1007/s11136-004-0374-1CrossRef
16.
Natani GD, Jain NK, Sharma TN, Gehlot PS, Agrawal SP, Koolwal S, Gupta RB, Agnihotri SP: Depression in tuberculosis patients: correlation with duration of disease and response to anti-tuberculous chemotherapy. Indian Journal of Tuberculosis 1985, 32: 195–198.
17.
Kelly-Rossini L, Perlman DC, Mason DJ: The experience of respiratory isolation for HIV-infected with TB. J Assoc Nurses AIDS Care 1996, 7: 29–36. 10.1016/S1055-3290(96)80035-5CrossRef
18.
Rajeswari R, Muniyandi M, Balasubramanian R, Narayanan PR: Perceptions of tuberculosis patients about their physical, mental and social well-being: A field report from south India. Soc Sci Med 2005, 60: 1845–1853. 10.1016/j.socscimed.2004.08.024CrossRef
19.
de Figueiredo AA, Lucon AM, Srougi M: Bladder augmentation for the treatment of chronic tuberculous cystitis. Clinical and urodynamic evaluation of 25 patients after long term follow-up. Neurourol Urodyn 2006, 25: 433–440. 10.1002/nau.20264CrossRef
20.
Dhingra VK, Rajpal S: Health related quality of life (HRQL) scoring in tuberculosis. Indian J Tuberc 2003, 50: 99–104.
21.
Dhingra VK, Rajpal S: Health related quality of life (HRQL) scoring (DR-12 score) in tuberculosis – additional evaluative tool under DOTS. J Commun Dis 2005, 37: 261–268.
22.
Ji Q, Sun Y-J, Liu Q-G, Gong F-Q, Jin Y, Wu J: Correlation of mental status and social function with quality of life in patients with tuberculosis. Zhongguo Linchuang Kangfu 2006, 10: 21–24.
23.
Dion MJ, Tousignant P, Bourbeau J, Menzies D, Schwartzman K: Feasibility and reliability of health-related quality of life measurements among tuberculosis patients. Qual Life Res 2004, 13: 653–665. 10.1023/B:QURE.0000021320.89524.64CrossRef
24.
Dion MJ, Tousignant P, Bourbeau J, Menzies D, Schwartzman K: Measurement of health preferences among patients with tuberculous infection and disease. Med Decis Making 2002,22(Suppl 5):102–114. 10.1177/027298902237706CrossRef
25.
Marra CA, Marra F, Colley L, Moadebi S, Elwood RK, Fitzgerald JM: Health-Related Quality of Life Trajectories among Adults with Tuberculosis: Differences between Latent and Active Infection. Chest 2008, 133: 396–403. 10.1378/chest.07-1494CrossRef
26.
Guo N, Marra CA, Marra F, Moadebi S, Elwood RK, Fitzgerald JM: Health State Utilities in Latent and Active Tuberculosis. Value Health 2008, 11: 1154–1161. 10.1111/j.1524-4733.2008.00355.xCrossRef
27.
Wang Y, Lii J, Lu F: Measuring and assessing the quality of life of patients with pulmonary tuberculosis. Zhonghua Jie He He Hu Xi Za Zhi 1998,21(12):720–723.
28.
Chamla D: The assessment of patients' health-related quality of life during tuberculosis treatment in Wuhan, China. Int J Tuberc Lung Dis 2004, 8: 1100–1106.
29.
Yang L, Wu DL, Guo HG, Liu JW: A study of the psychological and social factors in patients with pulmonary tuberculosis. Zhonghua Jie He He Hu Xi Za Zhi 2003,26(11):704–707.
30.
Duyan V, Kurt B, Aktas Z, Duyan GC, Kulkul DO: Relationship between quality of life and characteristics of patients hospitalised with tuberculosis. Int J Tuberc Lung Dis 2005, 9: 1361–1366.
31.
Aydin IO, Ulusahin A: Depression, anxiety comorbidity, and disability in tuberculosis and chronic obstructive pulmonary disease patients: applicability of GHQ-12. Gen Hosp Psychiatry 2001, 23: 77–83. 10.1016/S0163-8343(01)00116-5CrossRef
32.
Nyamathi A, Berg J, Jones T, Leake B: Predictors of perceived health status of tuberculosis-infected homeless. West J Nurs Res 2005, 27: 896–910. 10.1177/0193945905278385CrossRef
33.
He CY, He LM, Li MH: Application of SF-36 scale on pulmonary tuberculosis patients in Yunnan province of China and southern Thailand. Zhonghua Liu Xing Bing Xue Za Zhi 2005,26(3):187–189.
34.
Pasipanodya JG, Miller TL, Vecino M, Munguia G, Bae S, Drewyer G, Weis SE: Using the St. George respiratory questionnaire to ascertain health quality in persons with treated pulmonary tuberculosis. Chest 2007, 132: 1591–1598. 10.1378/chest.07-0755CrossRef
35.
Muniyandi M, Rajeswari R, Balasubramanian R, Nirupa C, Gopi PG, Jaggarajamma K, Sheela F, Narayanan PR: Evaluation of post-treatment health-related quality of life (HRQoL) among tuberculosis patients. Int J Tuberc Lung Dis 2007, 11: 887–892.
36.
Hays RD, Morales LS: The RAND-36 measure of health-related quality of life. Ann Med 2001, 33: 350–357. 10.3109/07853890109002089CrossRef
37.
Greenley JR, Greenberg JS, Brown R: Measuring quality of life: a new and practical survey instrument. Soc Work 1997, 42: 244–254.CrossRef
38.
39.
Jones PW, Quirk FH, Baveystock CM: The St George's Respiratory Questionnaire. Respir Med 1991,85(Suppl B):25–31. 10.1016/S0954-6111(06)80166-6CrossRef
40.
Derogatis LR, Lipman RS, Covi L: SCL-90: an outpatient psychiatric rating scale – preliminary report. Psychopharmacol Bull 1973, 9: 13–28.
41.
Golderberg D, Williams P: A user's guide to the General Health Questionnaire. Windsor, UK: NFER-Nelson; 1988.
42.
Stewart AL, Hays RD, Ware JE: The MOS short form general health survey: reliability and validity in a patient population. Med Care 1988, 26: 724–732. 10.1097/00005650-198807000-00007CrossRef
43.
Beck AT, Steer RA, Brown GK: Manual for the Beck Depression Inventory-II. San Antonio, TX: Psychological Corporation; 1996.
44.
Horsman J, Furlong W, Feeny D, Torrance G: The Health Utilities Index (HUI): concepts, measurement properties and applications. Health Qual Life Outcomes 2003, 16: 54. 10.1186/1477-7525-1-54CrossRef
45.
Brazier J, Roberts J, Deveril M: The estimation of a preference-based measure of health from the SF-36. J Health Econ 2002, 21: 271–292. 10.1016/S0167-6296(01)00130-8CrossRef
46.
House JS, Landis KR, Umberson D: Social relationships and health. Science 1988, 241: 540–545. 10.1126/science.3399889CrossRef
47.
48.
Sloan JA, Symonds T, Vargas-Chanes D, Friedly B: Practical guidelines for assessing the clinical significance of heath related quality of life changes within clinical trials. Drug Inf J 2003, 37: 23–31.
49.
Samsa G, Edelman D, Rothman ML, Williams GR, Lipscomb J, Matchar D: Determining clinically important differences in health status measures: a general approach with illustration to the Health Utilities Index Mark II. Pharmacoeconomics 1999, 15: 141–155. 10.2165/00019053-199915020-00003CrossRef
Metadata
Title
Measuring health-related quality of life in tuberculosis: a systematic review
Authors
Na Guo
Fawziah Marra
Carlo A Marra
Publication date
01-12-2009
Publisher
BioMed Central
Published in
Health and Quality of Life Outcomes / Issue 1/2009
Electronic ISSN: 1477-7525
DOI
https://doi.org/10.1186/1477-7525-7-14

Other articles of this Issue 1/2009

Health and Quality of Life Outcomes 1/2009 Go to the issue

Research

Additional impact of concomitant hypertension and osteoarthritis on quality of life among patients with type 2 diabetes in primary care in Germany – a cross-sectional survey

Research

Fear of hypoglycaemia: defining a minimum clinically important difference in patients with type 2 diabetes

Research

Sex differences in the relative contribution of social and clinical factors to the Health Utilities Index Mark 2 measure of health-related quality of life in older home care clients

Research

Relationship between the EQ-5D index and measures of clinical outcomes in selected studies of cardiovascular interventions

Research

Prospective evaluation of chronic pain associated with posterior autologous iliac crest bone graft harvest and its effect on postoperative outcome

Research

Do neurooncological patients and their significant others agree on quality of life ratings?