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Health and Quality of Life Outcomes
Published in: Health and Quality of Life Outcomes 1/2005

Open Access 01-12-2005 | Research

The influence of demographic factors and health-related quality of life on treatment satisfaction in patients with gastroesophageal reflux disease treated with esomeprazole

Authors: Alessio Degl' Innocenti, Gordon H Guyatt, Ingela Wiklund, Diane Heels-Ansdell, David Armstrong, Carlo A Fallone, Lisa Tanser, Sander Veldhuyzen van Zanten, Samer El-Dika, Naoki Chiba, Alan N Barkun, Peggy Austin, Holger J Schünemann

Published in: Health and Quality of Life Outcomes | Issue 1/2005

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Abstract

Background

The correlation between treatment satisfaction and demographic characteristics, symptoms, or health-related quality of life (HRQL) in patients with gastroesophageal reflux disease (GERD) is unknown. The objective of this study was to assess correlates of treatment satisfaction in patients with GERD receiving a proton pump inhibitor, esomeprazole.

Methods

Adult GERD patients (n = 217) completed demography, symptom, HRQL, and treatment satisfaction questionnaires at baseline and/or after treatment with esomeprazole 40 mg once daily for 4 weeks. We used multiple linear regressions with treatment satisfaction as the dependent variable and demographic characteristics, baseline symptoms, baseline HRQL, and change scores in HRQL as independent variables.

Results

Among the demographic variables only Caucasian ethnicity was positively associated with treatment satisfaction. Greater vitality assessed by the Quality of Life in Reflux and Dyspepsia (QOLRAD) and worse heartburn assessed by a four-symptom scale at baseline, were associated with greater treatment satisfaction. The greater the improvement on the QOLRAD vitality (change score), the more likely the patient is to be satisfied with the treatment.

Conclusions

Ethnicity, baseline vitality, baseline heartburn severity, and change in QOLRAD vitality correlate with treatment satisfaction in patients with GERD.
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Metadata
Title
The influence of demographic factors and health-related quality of life on treatment satisfaction in patients with gastroesophageal reflux disease treated with esomeprazole
Authors
Alessio Degl' Innocenti
Gordon H Guyatt
Ingela Wiklund
Diane Heels-Ansdell
David Armstrong
Carlo A Fallone
Lisa Tanser
Sander Veldhuyzen van Zanten
Samer El-Dika
Naoki Chiba
Alan N Barkun
Peggy Austin
Holger J Schünemann
Publication date
01-12-2005
Publisher
BioMed Central
Published in
Health and Quality of Life Outcomes / Issue 1/2005
Electronic ISSN: 1477-7525
DOI
https://doi.org/10.1186/1477-7525-3-4

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