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Health and Quality of Life Outcomes
Published in: Health and Quality of Life Outcomes 1/2013

Open Access 01-12-2013 | Research

Preference-based Health status in a German outpatient cohort with multiple sclerosis

Authors: Jens Peter Reese, Gabriele Wienemann, Axel John, Alexandra Linnemann, Monika Balzer-Geldsetzer, Ulrich Otto Mueller, Christian Eienbröker, Björn Tackenberg, Richard Dodel

Published in: Health and Quality of Life Outcomes | Issue 1/2013

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Abstract

Background

To prospectively determine health status and health utility and its predictors in patients with multiple sclerosis (MS).

Methods

A total of 144 MS patients (mean age: 41.0 ±11.3y) with different subtypes (patterns of progression) and severities of MS were recruited in an outpatient university clinic in Germany. Patients completed a questionnaire at baseline (n = 144), 6 months (n = 65) and 12 months (n = 55). Health utilities were assessed using the EuroQol instrument (EQ-5D, EQ VAS). Health status was assessed by several scales (Expanded Disability Severity Scale (EDSS), Modified Fatigue Impact Scale (M-FIS), Functional Assessment of MS (FAMS), Beck Depression Inventory (BDI-II) and Multiple Sclerosis Functional Composite (MSFC)). Additionally, demographic and socioeconomic parameters were assessed. Multivariate linear and logistic regressions were applied to reveal independent predictors of health status.

Results

Health status is substantially diminished in MS patients and the EQ VAS was considerably lower than that of the general German population. No significant change in health-status parameters was observed over a 12-months period. Multivariate analyses revealed M-FIS, BDI-II, MSFC, and EDSS to be significant predictors of reduced health status. Socioeconomic and socio-demographic parameters such as working status, family status, number of household inhabitants, age, and gender did not prove significant in multivariate analyses.

Conclusion

MS considerably impairs patients’ health status. Guidelines aiming to improve self-reported health status should include treatment options for depression and fatigue. Physicians should be aware of depression and fatigue as co-morbidities. Future studies should consider the minimal clinical difference when health status is a primary outcome.
Appendix
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Metadata
Title
Preference-based Health status in a German outpatient cohort with multiple sclerosis
Authors
Jens Peter Reese
Gabriele Wienemann
Axel John
Alexandra Linnemann
Monika Balzer-Geldsetzer
Ulrich Otto Mueller
Christian Eienbröker
Björn Tackenberg
Richard Dodel
Publication date
01-12-2013
Publisher
BioMed Central
Published in
Health and Quality of Life Outcomes / Issue 1/2013
Electronic ISSN: 1477-7525
DOI
https://doi.org/10.1186/1477-7525-11-162

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