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Health and Quality of Life Outcomes
Published in: Health and Quality of Life Outcomes 1/2013

Open Access 01-12-2013 | Research

Responsiveness of the Multiple Sclerosis International Quality of Life questionnaire to disability change: a longitudinal study

Authors: Karine Baumstarck, Helmut Butzkueven, Oscar Fernández, Peter Flachenecker, Sergio Stecchi, Egemen Idiman, Jean Pelletier, Mohamed Boucekine, Pascal Auquier

Published in: Health and Quality of Life Outcomes | Issue 1/2013

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Abstract

Background

Responsiveness, defined as the ability to detect a meaningful change, is a core psychometric property of an instrument measuring quality of life (QoL) rarely reported in multiple sclerosis (MS) studies.

Objective

To assess the responsiveness of the Multiple Sclerosis International Quality of Life (MusiQoL) questionnaire to change in disability over 24 months, defined by change in the Expanded Disability Status Scale (EDSS) score.

Methods

Patients with MS were enrolled into a multicenter, longitudinal observational study. QoL was assessed using both the MusiQoL and the 36-Item Short-Form (SF-36) instruments at baseline and every 6 months thereafter up to month 24; neurological assessments, including EDSS score, were performed at each evaluation.

Results

The 24-month EDSS was available for 524 patients. In the 107 worsened patients, two specific dimensions of MusiQoL, the sentimental and sexual life and the relationships with health care system dimensions, and ‘physical’ scores of SF-36 showed responsiveness.

Conclusions

Whereas specific dimensions of MusiQoL identified EDSS changes, the MusiQoL index did not detect disability changes in worsened MS patients in a 24-month observational study. Future responsiveness validation studies should include longer follow-up and more representative samples.
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Metadata
Title
Responsiveness of the Multiple Sclerosis International Quality of Life questionnaire to disability change: a longitudinal study
Authors
Karine Baumstarck
Helmut Butzkueven
Oscar Fernández
Peter Flachenecker
Sergio Stecchi
Egemen Idiman
Jean Pelletier
Mohamed Boucekine
Pascal Auquier
Publication date
01-12-2013
Publisher
BioMed Central
Published in
Health and Quality of Life Outcomes / Issue 1/2013
Electronic ISSN: 1477-7525
DOI
https://doi.org/10.1186/1477-7525-11-127

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