Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
Health and Quality of Life Outcomes
Published in: Health and Quality of Life Outcomes 1/2012

Open Access 01-12-2012 | Research

Translation and validation of the EORTC brain cancer module (EORTC QLQ-BN20) for use in Iran

Authors: Alireza Khoshnevisan, Mir Saeed Yekaninejad, Shahab Kamali Ardakani, Amir H Pakpour, Azam Mardani, Neil K Aaronson

Published in: Health and Quality of Life Outcomes | Issue 1/2012

Login to get access

Abstract

Background

The aim of this study was to translate the EORTC quality of life questionnaire for brain cancer, the QLQ-BN20, into Persian, and to evaluate its psychometric properties when used among brain cancer patients in Iran.

Methods

A standard backward and forward translation procedure was used to generate the Persian language version of the QLQ-BN20. The QLQ-BN20 was administered together with the QLQ-C30 to 194 patients diagnosed with primary brain cancer. Multitrait scaling and confirmatory factor analysis (CFA) were used to evaluate the hypothesized scale structure of the questionnaire. Internal consistency reliability was estimated with Cronbach’s alpha. The ability of the QLQ-BN20 to distinguish between patient subgroups formed on the basis of performance status and cognitive status was evaluated, as was the responsiveness of the questionnaire to changes in performance status over time.

Results

Multitrait scaling and CFA results confirmed the hypothesized scale structure. The measurement model was consistent across men and women. Internal consistency reliability of the multi-item scales ranged from 0.74 to 0.89. The QLQ-BN20 distinguished clearly between patients with relatively good versus poor performance and cognitive status, and changes in scores over time reflected changes observed in performance status ratings.

Conclusions

These results support the validity and reliability of the QLQ-BN20 for use among Iranian patients diagnosed with primary brain cancer. Future studies should examine the psychometrics of the questionnaire when used in patients with brain metastasis.
Appendix
Available only for authorised users
Literature
1.
Jemal A, Siegel R, Xu J, Ward E: Cancer statistics, 2010. CA: a cancer j clinicians 2010, 60(5):277–300. 10.3322/caac.20073
2.
Iran center for disease control and prevention, cancer office: Iranian annual of national cancer registration report 2006–2007. Ministry of health, Tehran; 2008.
3.
4.
Kirkbride P, Tannock IF: Trials in palliative treatment – have the goal posts been moved? Lancet Oncology 2008, 9: 186–187. 10.1016/S1470-2045(08)70041-XCrossRefPubMed
5.
Stupp R, Mason WP, van den Bent MJ, et al.: Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med 2005, 352: 987–996. 10.1056/NEJMoa043330CrossRefPubMed
6.
Brandsma D, van den Bent MJ: Molecular targeted therapies and chemotherapy in malignant gliomas. Curr Opin Oncol 2007, 19(6):598–605. 10.1097/CCO.0b013e3282f0313bCrossRefPubMed
7.
Aaronson NK, Ahmedzai S, Bergman B, et al.: The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. J Nat Cancer Institute 1993, 85(5):365–376. 10.1093/jnci/85.5.365CrossRef
8.
Cella DF, Tulsky DS, Gray G, et al.: The Functional Assessment of Cancer Therapy Scale: development and validation of the general measure. J oncology: official j Am Soc Clin Oncology 1993, 11(3):570–579.
9.
Osoba D, Aaronson NK, Muller M, et al.: The development and psychometric validation of a brain cancer quality-of-life questionnaire for use in combination with general cancer specific questionnaires. Quality of Life Res 1996, 5(1):139–150. 10.1007/BF00435979CrossRef
10.
Taphoorn MJ, Claassens L, Aaronson NK, Coens C, Mauer M, Osoba D, Stupp R, Mirimanoff RO, van den Bent MJ, Bottomley A: EORTC Quality of Life Group, and Brain Cancer, NCIC and Radiotherapy Groups. An international validation study of the EORTC brain cancer module (EORTC QLQ-BN20) for assessing health-related quality of life and symptoms in brain cancer patients. Eur J Cancer 2010, 46(6):1033–1040. 10.1016/j.ejca.2010.01.012CrossRefPubMed
11.
Fayers PM, Aaronson NK, Bjordal K, Groenvold M, Curran D, Bottomley A: on behalf of the EORTC Quality of Life Group. 3rd edition. EORTC, Brussels; 2001.
12.
Cull A, Sprangers MAG, Aaronson NK: On behalf of the EORTC Quality of Life Study Group. European Organization for Research and Treatment of Cancer quality of life study group translation procedure, Internal report of the EORTC Study Group on Quality of Life; 1994.
13.
Montazeri A, Harirchi I, Vahdani M, Khaleghi F, Jarvandi S, Ebrahimi M, Haji-Mahmoodi M: The European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30): translation and validation study of the Iranian version. Supportive Care in Cancer 1999, 7(6):400–406. 10.1007/s005200050300CrossRefPubMed
14.
Terwee CB, Bot SD, de Boer MR, et al.: Quality criteria were proposed for measurement properties of health status questionnaires. J Clin Epidemiol 2007, 60: 34–42. 10.1016/j.jclinepi.2006.03.012CrossRefPubMed
15.
Fayers PM, Machin D: Quality of Life: Assessment, Analysis and Interpretation. John Wiley & Sons, Chichester; 2000.CrossRef
16.
Browne MW, Cudeck R: Alternative ways of assessing model fit. Sociological Methods & Res 1992, 21: 230–258. 10.1177/0049124192021002005CrossRef
17.
Sivo SA, Fan X, Witta EL, Willse JT: The search for optimal cutoff properties: Fit index criteria in structural equation modeling. J Exp Educ 2006, 74: 267–288. 10.3200/JEXE.74.3.267-288CrossRef
18.
Hu L, Bentler PM: Cutoff criteria for fit indices in covariance structure analysis: Conventional criteria versus new alternatives. Struct Equ Model 1999, 6: 1–55. 10.1080/10705519909540118CrossRef
19.
Enders CK, Bandalos DL: The relative performance of full information maximum likelihood estimation for missing data in structural equation models. Struct Equ Model 2001, 8: 430–457. 10.1207/S15328007SEM0803_5CrossRef
20.
Cheung GW, Rensvold RB: Evaluating goodness-of-fit indexes for testing measurement invariance. Struct Equ Model 2002, 9: 233–255. 10.1207/S15328007SEM0902_5CrossRef
21.
Nunnally JC, Bernstein IR: Psychometric Theory. 3rd edition. McGraw-Hill, New York; 1994.
22.
Benjamini Y, Hochberg Y: Controlling the false discovery rate: a practical and powerful approach to multiple testing. J Royal Statistical Society: Series B 1995, 57: 289–300. Retrieved http://​www.​jstor.​org
23.
Benjamini Y, Krieger AM, Yekutieli D: Adaptive linear step-up procedures that control the false discovery rate. Biometrika 2006, 93: 491–507. 10.1093/biomet/93.3.491CrossRef
24.
25.
Janda M, Steginga S, Langbecker D, Dunn J, Walker D, Eakin E: Quality of life among patients with a brain tumor and their carers. J Psychosom Res 2007, 63(6):617–623. 10.1016/j.jpsychores.2007.06.018CrossRefPubMed
26.
Mainio A, Hakko H, Niemelä A, Koivukangas J, Räsänen P: Gender difference in relation to depression and quality of life among patients with a primary brain tumor. Eur Psychiatry 2006, 21(3):194–199. 10.1016/j.eurpsy.2005.05.008CrossRefPubMed
27.
Niemelä A, Koivukangas J, Herva R, Hakko H, Räsänen P: Gender Difference in Quality of Life among Brain Tumor Survivors. J Neurol Neurophysiol 2011, 2: 118.CrossRef
28.
Fischer R, Ferreira MC, Assmar E, Redford P, Harb C, Glazer S, Cheng BS, Jiang DY, Wong C, Kumar N, Kärtner J, Hofer J, Achoui M: Individualism-collectivism as descriptive norms: Development of a subjective norm approach to culture measurement. Journal of Cross-Cultural Psychology 2009, 40: 187–213. 10.1177/0022022109332738CrossRef
Metadata
Title
Translation and validation of the EORTC brain cancer module (EORTC QLQ-BN20) for use in Iran
Authors
Alireza Khoshnevisan
Mir Saeed Yekaninejad
Shahab Kamali Ardakani
Amir H Pakpour
Azam Mardani
Neil K Aaronson
Publication date
01-12-2012
Publisher
BioMed Central
Published in
Health and Quality of Life Outcomes / Issue 1/2012
Electronic ISSN: 1477-7525
DOI
https://doi.org/10.1186/1477-7525-10-54

Other articles of this Issue 1/2012

Health and Quality of Life Outcomes 1/2012 Go to the issue

Research

Prevalence and impacts of poor sleep on quality of life and associated factors of good sleepers in a sample of older Chinese adults

Research

Health-related quality of life in patients with dual diagnosis: clinical correlates

Review

A systematic review of quality of life instruments in long-term breast cancer survivors

Study protocol

A pilot randomized controlled trial of the feasibility of a self-directed coping skills intervention for couples facing prostate cancer: Rationale and design

Research

Identification of aspects of functioning, disability and health relevant to patients experiencing vertigo: a qualitative study using the international classification of functioning, disability and health

Research

An exploratory study of the perceived impact of health problems of landmine/UXO victims versus another disability group