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Clinical and Molecular Allergy
Published in: Clinical and Molecular Allergy 1/2005

Open Access 01-12-2005 | Case Report

Insulin allergy and resistance successfully treated by desensitisation with Aspart insulin

Authors: Victor Matheu, Eva Perez, Marta Hernández, Elisa Díaz, Ricardo Darias, Abel González, Jose C García, Inmaculada Sánchez, Laura Feliciano, Agueda Caballero, Fernando de la Torre

Published in: Clinical and Molecular Allergy | Issue 1/2005

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Abstract

A 25-year-old, with type I Diabetes Mellitus with a previous diagnosis of Protamine Allergy but not to human Insulin, started to notice anaphylactic reactions inmmediatly after bolus with Insulin. Skin prick and intradermal test were positive to all insulins. Skin tests to other potential allergens resulted negative. Examination after bolus of Human Insulin revealed urticaria. Daily insulin requirement were around 2-2,4 U/Kg/day. Slow desensitisation with Aspart insulin, the insulin with lowest size of skin test, was performed using subcutaneous insulin pump. Six months after the end of desensitisation his daily insulin requirement decreased to 0.8 U/Kg/day and oral corticosteroids are being reduced with no symptoms.
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Metadata
Title
Insulin allergy and resistance successfully treated by desensitisation with Aspart insulin
Authors
Victor Matheu
Eva Perez
Marta Hernández
Elisa Díaz
Ricardo Darias
Abel González
Jose C García
Inmaculada Sánchez
Laura Feliciano
Agueda Caballero
Fernando de la Torre
Publication date
01-12-2005
Publisher
BioMed Central
Published in
Clinical and Molecular Allergy / Issue 1/2005
Electronic ISSN: 1476-7961
DOI
https://doi.org/10.1186/1476-7961-3-16

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