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Molecular Cancer
Published in: Molecular Cancer 1/2010

Open Access 01-12-2010 | Review

Leucine-rich repeat protein PRAME: expression, potential functions and clinical implications for leukaemia

Authors: Frances Wadelin, Joel Fulton, Paul A McEwan, Keith A Spriggs, Jonas Emsley, David M Heery

Published in: Molecular Cancer | Issue 1/2010

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Abstract

PRAME/MAPE/OIP4 is a germinal tissue-specific gene that is also expressed at high levels in haematological malignancies and solid tumours. The physiological functions of PRAME in normal and tumour cells are unknown, although a role in the regulation of retinoic acid signalling has been proposed. Sequence homology and structural predictions suggest that PRAME is related to the leucine-rich repeat (LRR) family of proteins, which have diverse functions. Here we review the current knowledge of the structure/function of PRAME and its relevance in leukaemia.
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Metadata
Title
Leucine-rich repeat protein PRAME: expression, potential functions and clinical implications for leukaemia
Authors
Frances Wadelin
Joel Fulton
Paul A McEwan
Keith A Spriggs
Jonas Emsley
David M Heery
Publication date
01-12-2010
Publisher
BioMed Central
Published in
Molecular Cancer / Issue 1/2010
Electronic ISSN: 1476-4598
DOI
https://doi.org/10.1186/1476-4598-9-226

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