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Molecular Cancer
Published in: Molecular Cancer 1/2006

Open Access 01-12-2006 | Research

Apigenin inhibits pancreatic cancer cell proliferation through G2/M cell cycle arrest

Authors: Michael B Ujiki, Xian-Zhong Ding, M Reza Salabat, David J Bentrem, Laleh Golkar, Ben Milam, Mark S Talamonti, Richard H Bell Jr, Takeshi Iwamura, Thomas E Adrian

Published in: Molecular Cancer | Issue 1/2006

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Abstract

Background

Many chemotherapeutic agents have been used to treat pancreatic cancer without success. Apigenin, a naturally occurring flavonoid, has been shown to inhibit growth in some cancer cell lines but has not been studied in pancreatic cancer. We hypothesized that apigenin would inhibit pancreatic cancer cell growth in vitro.

Results

Apigenin caused both time- and concentration-dependent inhibition of DNA synthesis and cell proliferation in four pancreatic cancer cell lines. Apigenin induced G2/M phase cell cycle arrest. Apigenin reduced levels of cyclin A, cyclin B, phosphorylated forms of cdc2 and cdc25, which are all proteins required for G2/M transition.

Conclusion

Apigenin inhibits growth of pancreatic cancer cells through suppression of cyclin B-associated cdc2 activity and G2/M arrest, and may be a valuable drug for the treatment or prevention of pancreatic cancer.
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Metadata
Title
Apigenin inhibits pancreatic cancer cell proliferation through G2/M cell cycle arrest
Authors
Michael B Ujiki
Xian-Zhong Ding
M Reza Salabat
David J Bentrem
Laleh Golkar
Ben Milam
Mark S Talamonti
Richard H Bell Jr
Takeshi Iwamura
Thomas E Adrian
Publication date
01-12-2006
Publisher
BioMed Central
Published in
Molecular Cancer / Issue 1/2006
Electronic ISSN: 1476-4598
DOI
https://doi.org/10.1186/1476-4598-5-76

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