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Molecular Cancer
Published in: Molecular Cancer 1/2004

Open Access 01-12-2004 | Short communication

Genetic alterations and in vivo tumorigenicity of neurospheres derived from an adult glioblastoma

Authors: Patrizia Tunici, Lorena Bissola, Elena Lualdi, Bianca Pollo, Laura Cajola, Giovanni Broggi, Gabriella Sozzi, Gaetano Finocchiaro

Published in: Molecular Cancer | Issue 1/2004

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Abstract

Pediatric brain tumors may originate from cells endowed with neural stem/precursor cell properties, growing in vitro as neurospheres. We have found that these cells can also be present in adult brain tumors and form highly infiltrating gliomas in the brain of immunodeficient mice. Neurospheres were grown from three adult brain tumors and two pediatric gliomas. Differentiation of the neurospheres from one adult glioblastoma decreased nestin expression and increased that of glial and neuronal markers. Loss of heterozygosity of 10q and 9p was present in the original glioblastoma, in the neurospheres and in tumors grown into mice, suggesting that PTEN and CDKN2A alterations are key genetic events in tumor initiating cells with neural precursor properties.
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Metadata
Title
Genetic alterations and in vivo tumorigenicity of neurospheres derived from an adult glioblastoma
Authors
Patrizia Tunici
Lorena Bissola
Elena Lualdi
Bianca Pollo
Laura Cajola
Giovanni Broggi
Gabriella Sozzi
Gaetano Finocchiaro
Publication date
01-12-2004
Publisher
BioMed Central
Published in
Molecular Cancer / Issue 1/2004
Electronic ISSN: 1476-4598
DOI
https://doi.org/10.1186/1476-4598-3-25

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