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Molecular Cancer
Published in: Molecular Cancer 1/2013

Open Access 01-12-2013 | Letter to the Editor

The T-box transcription factor, TBX3, is sufficient to promote melanoma formation and invasion

Authors: Jade Peres, Sharon Prince

Published in: Molecular Cancer | Issue 1/2013

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Abstract

The T-box transcription factor, TBX3, is overexpressed in several cancers and has been proposed as a chemotherapeutic target. Several lines of evidence suggest that TBX3 may be a key contributor to malignant melanoma, a highly aggressive and intractable disease. Using in vitro and in vivo assays we demonstrate here for the first time that overexpressing TBX3 in non-tumourigenic early stage melanoma cells is sufficient to promote tumour formation and invasion. Furthermore, we show that TBX3 may play an important role as a reciprocal switch between substrate dependent cell proliferation and tumour invasion.
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Literature
1.
Jemal A, Siegel R, Ward E, Hao Y, Xu J, Thun MJ: Cancer statistics, 2009. Cancer J Clin. 2009, 59 (4): 225-249. 10.3322/caac.20006.CrossRef
2.
King R, Weilbaecher KN, McGill G, Cooley E, Mihm M, Fisher DE: Microphthalmia transcription factor: a sensitive and specific melanocyte marker for melanoma diagnosis. Am J Pathol. 1999, 155: 731-738. 10.1016/S0002-9440(10)65172-3PubMedCentralCrossRefPubMed
3.
Vachtenheimer J, Novotma H: Expression of genes for microphthalmia isoforms, PAX3 and MSGI, in human melanomas. Cell Mol Biol. 1999, 45: 1075-1082.
4.
Cano A, Perez-Moreno MA, Rodrigo I, Locascio A, Blanco MJ, del Barrio MG, Portillo F, Nieto MA: The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression. Nat Cell Biol. 2000, 2: 76-83. 10.1038/35000025CrossRefPubMed
5.
Brummelkamp TR, Kortlever RM, Lingbeek M, Trettel F, MacDonald ME, van Lohuizen M, Bernards R: TBX-3, the gene mutated in Ulnar- Mammary Syndrome is a negative regulator of p19 ARF and inhibits senescence. J Biol Chem. 2002, 277: 6567-6572. 10.1074/jbc.M110492200CrossRefPubMed
6.
Lingbeek ME, Jacobs JJ, van Lohuizen M: The T-box repressors TBX2 and TBX3 specifically regulate the tumor suppressor gene p14ARF via a variant T site in the initiator. J Biol Chem. 2002, 277: 26120-26127. 10.1074/jbc.M200403200CrossRefPubMed
7.
Hoek K, Rimm DL, Williams KR, Zhao H, Ariyan S, Lin A, Kluger HM, Berger AJ, Cheng E, Trombetta ES, Wu T, Niinobe M, Yoshikawa K, Hannigan GE, Halaban R: Expression profiling reveals novel pathways in the transformation of melanocytes to melanomas. Cancer Res. 2004, 64: 5270-5282. 10.1158/0008-5472.CAN-04-0731CrossRefPubMed
8.
Peres J, Davis E, Mowla S, Bennett DC, Li JA, Wansleben S, Prince S: The highly homologous T-Box transcription factors, TBX2 and TBX3, have distinct roles in the oncogenic process. Genes Cancer. 2010, 1: 272-282. 10.1177/1947601910365160PubMedCentralCrossRefPubMed
9.
Rodriguez M, Aladowicz E, Lanfrancone L, Goding CR: Tbx3 represses E-Cadherin expression and enhances melanoma invasiveness. Cancer Res. 2008, 68 (19): 7872-7881. 10.1158/0008-5472.CAN-08-0301CrossRefPubMed
10.
Boyd SC, Mijatov B, Pupo GM, Tran SL, Gowrishankar K, Shaw HM, Goding CR, Scolyer RA, Mann GJ, Kefford RF, Rizos H, Becker TM: Oncogenic B-RAFV600E signaling induces the T-box3 transcriptional repressor to repress E-cadherin and enhance melanoma cell invasion. J Investig Dermatol. doi:10.1038/jid.2012.421. advance online publication, 20 September 2012,
11.
Redmond KL, Crawford NT, Farmer H, D'Costa ZC, O'Brien GJ, Buckley NE, Kennedy RD, Johnston PG, Harkin DP, Mullan PB: T-box 2 represses NDRG1 through an EGR1-dependent mechanism to drive the proliferation of breast cancer cells. Oncogene. 2010, 29: 3252-3262. 10.1038/onc.2010.84CrossRefPubMed
Metadata
Title
The T-box transcription factor, TBX3, is sufficient to promote melanoma formation and invasion
Authors
Jade Peres
Sharon Prince
Publication date
01-12-2013
Publisher
BioMed Central
Published in
Molecular Cancer / Issue 1/2013
Electronic ISSN: 1476-4598
DOI
https://doi.org/10.1186/1476-4598-12-117

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