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Cancer Cell International
Published in: Cancer Cell International 1/2005

Open Access 01-12-2005 | Review

Cancer/testis antigens and gametogenesis: a review and "brain-storming" session

Authors: Martins Kalejs, Jekaterina Erenpreisa

Published in: Cancer Cell International | Issue 1/2005

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Abstract

Genes expressed both in normal testis and in malignancies (Cancer/ Testis associated genes – CTA) have become the most extensively studied antigen group in the field of tumour immunology. Despite this, many fundamentally important questions remain unanswered: what is the connection between germ-cell specific genes and tumours? Is the expression of these genes yet another proof for the importance of genome destabilisation in the process of tumorigenesis?, or maybe activation of these genes is not quite random but instead related to some programme giving tumours a survival advantage?
This review collates most of the recent information available about CTAs expression, function, and regulation. The data suggests a programme related to ontogenesis, mostly to gametogenesis. In the "brain-storming" part, facts in conflict with the hypothesis of random CTA gene activation are discussed. We propose a programme borrowed from organisms phylogenetically much older than humans, which existed before the differentiation of sexes. It is a programme that has served as a life cycle with prominent ploidy changes, and from which, as we know, the germ-cell ploidy cycle – meiosis – has evolved. Further work may show whether this hypothesis can lead to a novel anti-tumour strategy.
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Metadata
Title
Cancer/testis antigens and gametogenesis: a review and "brain-storming" session
Authors
Martins Kalejs
Jekaterina Erenpreisa
Publication date
01-12-2005
Publisher
BioMed Central
Published in
Cancer Cell International / Issue 1/2005
Electronic ISSN: 1475-2867
DOI
https://doi.org/10.1186/1475-2867-5-4

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Multidrug Resistance-Associated Protein 1 (MRP1) mediated vincristine resistance: effects of N-acetylcysteine and Buthionine Sulfoximine

Primary research

Responses of genes involved in cell cycle control to diverse DNA damaging chemicals in human lung adenocarcinoma A549 cells

Primary research

Establishment of a doxycycline-regulated cell line with inducible, doubly-stable expression of the wild-type p53 gene from p53-deleted hepatocellular carcinoma cells

Primary research

Human breast cancer cell-mediated bone collagen degradation requires plasminogen activation and matrix metalloproteinase activity
Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Watch now

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras
Prof. Fabrice Barlesi
Developed by: Springer Medicine
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