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Cancer Cell International
Published in: Cancer Cell International 1/2005

Open Access 01-12-2005 | Review

ABC transporters as multidrug resistance mechanisms and the development of chemosensitizers for their reversal

Author: Cheol-Hee Choi

Published in: Cancer Cell International | Issue 1/2005

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Abstract

One of the major problems related with anticancer chemotherapy is resistance against anticancer drugs. The ATP-binding cassette (ABC) transporters are a family of transporter proteins that are responsible for drug resistance and a low bioavailability of drugs by pumping a variety of drugs out cells at the expense of ATP hydrolysis. One strategy for reversal of the resistance of tumor cells expressing ABC transporters is combined use of anticancer drugs with chemosensitizers. In this review, the physiological functions and structures of ABC transporters, and the development of chemosensitizers are described focusing on well-known proteins including P-glycoprotein, multidrug resistance associated protein, and breast cancer resistance protein.
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Metadata
Title
ABC transporters as multidrug resistance mechanisms and the development of chemosensitizers for their reversal
Author
Cheol-Hee Choi
Publication date
01-12-2005
Publisher
BioMed Central
Published in
Cancer Cell International / Issue 1/2005
Electronic ISSN: 1475-2867
DOI
https://doi.org/10.1186/1475-2867-5-30

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