Skip to main content
Top
Published in: BMC Health Services Research 1/2006

Open Access 01-12-2006 | Research article

Does a joint development and dissemination of multidisciplinary guidelines improve prescribing behaviour: a pre/post study with concurrent control group and a randomised trial

Authors: Jody D Martens, Ron AG Winkens, Trudy van der Weijden, Daisy de Bruyn, Johan L Severens

Published in: BMC Health Services Research | Issue 1/2006

Login to get access

Abstract

Background

It is difficult to keep control over prescribing behaviour in general practices. The purpose of this study was to assess the effects of a dissemination strategy of multidisciplinary guidelines on the volume of drug prescribing.

Methods

The study included two designs, a quasi-experimental pre/post study with concurrent control group and a random sample of GPs within the intervention group. The intervention area with 53 GPs was compared with a control group of 54 randomly selected GPs in the south and centre of the Netherlands. Additionally, a randomisation was executed in the intervention group to create two arms with 27 GPs who were more intensively involved in the development of the guideline and 26 GPs in the control group.
A multidisciplinary committee developed prescription guidelines. Subsequently these guidelines were disseminated to all GPs in the intervention region. Additional effects were studied in the subgroup trial in which GPs were invited to be more intensively involved in the guideline development procedure. The guidelines contained 14 recommendations on antibiotics, asthma/COPD drugs and cholesterol drugs
The main outcome measures were prescription data of a three-year period (one year before and 2 years after guideline dissemination) and proportion of change according to recommendations.

Results

Significant short-term improvements were seen for one recommendation: mupirocin. Long-term changes were found for cholesterol drug prescriptions. No additional changes were seen for the randomised controlled study in the subgroup. GPs did not take up the invitation for involvement.

Conclusion

Disseminating multidisciplinary guidelines that were developed within a region, has no clear effect on prescribing behaviour even though GPs and specialists were involved more intensively in their development. Apparently, more effort is needed to bring about change.
Appendix
Available only for authorised users
Literature
1.
go back to reference Centraal Bureau voor de Statistiek: Statistisch jaarboek 2003 (Statistical yearbook 2003). 2003, Heerlen: Centraal Bureau voor de Statistiek, 96. Centraal Bureau voor de Statistiek: Statistisch jaarboek 2003 (Statistical yearbook 2003). 2003, Heerlen: Centraal Bureau voor de Statistiek, 96.
2.
go back to reference Stichting Farmaceutische Kengetallen: Data en Feiten (Foundation for Pharmaceutical Statistics; Data and facts). The Hague/the Netherlands;. 2000, –2004 Stichting Farmaceutische Kengetallen: Data en Feiten (Foundation for Pharmaceutical Statistics; Data and facts). The Hague/the Netherlands;. 2000, –2004
3.
go back to reference Breekveldt-Postma NS, Zwart-van Rijkom JE, Egberts AC, Leufkens HG, Herings RM: Rising costs of drugs in hospitals in the period 1996–2000 and over the next few years (Article in Dutch). Ned Tijdschr Geneeskd. 146 (52): 2547-51. 2002 Dec 28; Erratum in: Ned Tijdschr Geneeskd. 2003 Dec 27;247(52):2612. Ned Tijdschr Geneeskd. 2003 Jan 25;147(4):184 Breekveldt-Postma NS, Zwart-van Rijkom JE, Egberts AC, Leufkens HG, Herings RM: Rising costs of drugs in hospitals in the period 1996–2000 and over the next few years (Article in Dutch). Ned Tijdschr Geneeskd. 146 (52): 2547-51. 2002 Dec 28; Erratum in: Ned Tijdschr Geneeskd. 2003 Dec 27;247(52):2612. Ned Tijdschr Geneeskd. 2003 Jan 25;147(4):184
4.
go back to reference Dobson R: Pharmaceutical industry is main influence in GP prescribing. BMJ. 2003, 326: 301-10.1136/bmj.326.7384.301.CrossRef Dobson R: Pharmaceutical industry is main influence in GP prescribing. BMJ. 2003, 326: 301-10.1136/bmj.326.7384.301.CrossRef
5.
go back to reference Prosser H, Almond S, Walley T: Influences on GPs' decision to prescribe new drugs; the importance of who says what. Family Practice. 2003, 20 (1): 61-8. 10.1093/fampra/20.1.61.CrossRef Prosser H, Almond S, Walley T: Influences on GPs' decision to prescribe new drugs; the importance of who says what. Family Practice. 2003, 20 (1): 61-8. 10.1093/fampra/20.1.61.CrossRef
6.
go back to reference Evans J, Lambert T, Goldacre M: GP recruitment and retention: a qualitative analysis of doctors' comments about training for and working in general practice. Occas Pap R Coll Gen Pract. 2002, iii-vi. 1–33, 83 Evans J, Lambert T, Goldacre M: GP recruitment and retention: a qualitative analysis of doctors' comments about training for and working in general practice. Occas Pap R Coll Gen Pract. 2002, iii-vi. 1–33, 83
7.
go back to reference Grimshaw J, McAuley LM, Bero LA, Grilli R, Oxman AD, Ramsay C, Vale L, Zwarenstein : Systematic reviews of the effectiveness of quality improvement strategies and programmes. Qual Saf Health Care. 2003, 12 (4): 298-303. 10.1136/qhc.12.4.298.CrossRef Grimshaw J, McAuley LM, Bero LA, Grilli R, Oxman AD, Ramsay C, Vale L, Zwarenstein : Systematic reviews of the effectiveness of quality improvement strategies and programmes. Qual Saf Health Care. 2003, 12 (4): 298-303. 10.1136/qhc.12.4.298.CrossRef
8.
go back to reference Kosecoff J, Kanouse DE, Rogers WH, McCloskey L, Winslow CM, Brook RH: Effects of the national Institutes of Health Consensus Development Program on physician practice. JAMA. 1987, 258: 2708-13. 10.1001/jama.258.19.2708.CrossRef Kosecoff J, Kanouse DE, Rogers WH, McCloskey L, Winslow CM, Brook RH: Effects of the national Institutes of Health Consensus Development Program on physician practice. JAMA. 1987, 258: 2708-13. 10.1001/jama.258.19.2708.CrossRef
9.
go back to reference Grimshaw J, Eccles M, Tetroe J: Implementing clinical guidelines: current evidence and future implications. J Contin Educ Health Prof. 2004, 24 (Suppl 1): S31-7. 10.1002/chp.1340240506.CrossRef Grimshaw J, Eccles M, Tetroe J: Implementing clinical guidelines: current evidence and future implications. J Contin Educ Health Prof. 2004, 24 (Suppl 1): S31-7. 10.1002/chp.1340240506.CrossRef
10.
go back to reference Grol R: Implementation of evidence and guidelines in clinical practice: a new field of research?. Int J Qual Health Care. 2000, 12 (6): 455-456. 10.1093/intqhc/12.6.455.CrossRef Grol R: Implementation of evidence and guidelines in clinical practice: a new field of research?. Int J Qual Health Care. 2000, 12 (6): 455-456. 10.1093/intqhc/12.6.455.CrossRef
11.
go back to reference Jamtvedt G, Young JM, Kristoffersen DT, Thomson O'Brien MA, Oxman AD: Audit and feedback: effects on professional practice and health care outcomes. Cochrane Database Syst Rev. 2003, CD000259-3 Jamtvedt G, Young JM, Kristoffersen DT, Thomson O'Brien MA, Oxman AD: Audit and feedback: effects on professional practice and health care outcomes. Cochrane Database Syst Rev. 2003, CD000259-3
12.
go back to reference Bero LA, Grilli R, Grimshaw JM, Harvey E, Oxman AD, Thomson MA: Closing the gap between research and practice: an overview of systematic reviews of interventions to promote the implementation of research findings. The Cochrane Effective Practice and Organization of Care Review Group. BMJ. 317 (7156): 465-468. 1998 Aug 15 Bero LA, Grilli R, Grimshaw JM, Harvey E, Oxman AD, Thomson MA: Closing the gap between research and practice: an overview of systematic reviews of interventions to promote the implementation of research findings. The Cochrane Effective Practice and Organization of Care Review Group. BMJ. 317 (7156): 465-468. 1998 Aug 15
14.
go back to reference Grol R, Wensing M, Eccles M, (red): Improving Patient Care; The implementation of change in clinical practice. 2005, London: Elsevier Limited Grol R, Wensing M, Eccles M, (red): Improving Patient Care; The implementation of change in clinical practice. 2005, London: Elsevier Limited
15.
go back to reference Pagliari C, Grimshaw J, Eccles M: The potential influence of small group processes on guideline development. J Eval Clin Pract. 2001, 7 (2): 165-73. 10.1046/j.1365-2753.2001.00272.x.CrossRef Pagliari C, Grimshaw J, Eccles M: The potential influence of small group processes on guideline development. J Eval Clin Pract. 2001, 7 (2): 165-73. 10.1046/j.1365-2753.2001.00272.x.CrossRef
16.
go back to reference Hutchinson A, McIntosh A, Cox S, Gilbert C: Towards efficient guidelines: how to monitor guideline use in primary care. Health Technol Assess. 2003, 7 (18): iii-1–97CrossRef Hutchinson A, McIntosh A, Cox S, Gilbert C: Towards efficient guidelines: how to monitor guideline use in primary care. Health Technol Assess. 2003, 7 (18): iii-1–97CrossRef
18.
go back to reference Grol R: Personal paper. Beliefs and evidence in changing clinical practice. BMJ. 315 (7105): 418-421. 1997 Aug 16 Grol R: Personal paper. Beliefs and evidence in changing clinical practice. BMJ. 315 (7105): 418-421. 1997 Aug 16
19.
go back to reference Wise R, Haut T, Cars O: Antimicrobial resistance: is a major threat to public health. BMJ. 1998, 317: 609-10.CrossRef Wise R, Haut T, Cars O: Antimicrobial resistance: is a major threat to public health. BMJ. 1998, 317: 609-10.CrossRef
20.
go back to reference Worrall G, Young B, Knight V: Inappropriate use of antibiotics for acute respiratory tract infections in a rural emergency department. Can J Rural Med. 2005, 10 (2): 86-8.PubMed Worrall G, Young B, Knight V: Inappropriate use of antibiotics for acute respiratory tract infections in a rural emergency department. Can J Rural Med. 2005, 10 (2): 86-8.PubMed
21.
go back to reference Abookire SA, Karson AS, Fiskio J, Bates DW: Use and monitoring of "statin" lipid-lowering drugs compared with guidelines. Arch Intern Med. 161 (1): 53-8. 10.1001/archinte.161.1.53. 2001 Jan 8 Abookire SA, Karson AS, Fiskio J, Bates DW: Use and monitoring of "statin" lipid-lowering drugs compared with guidelines. Arch Intern Med. 161 (1): 53-8. 10.1001/archinte.161.1.53. 2001 Jan 8
22.
go back to reference Grimshaw JM, Russell IT: Achieving health gain through clinical guidelines II: Ensuring guidelines change medical practice. Qual Health Care. 1994, 3 (1): 45-52.CrossRef Grimshaw JM, Russell IT: Achieving health gain through clinical guidelines II: Ensuring guidelines change medical practice. Qual Health Care. 1994, 3 (1): 45-52.CrossRef
24.
go back to reference Winkens RA, Pop P, Bugter-Maessen AM, Grol RP, Kester AD, Beusmans GH, Knottnerus JA: Randomised controlled trial of routine individual feedback to improve rationality and reduce numbers of test requests. Lancet. 345 (8948): 498-502. 10.1016/S0140-6736(95)90588-X. 1995 Feb 25 Winkens RA, Pop P, Bugter-Maessen AM, Grol RP, Kester AD, Beusmans GH, Knottnerus JA: Randomised controlled trial of routine individual feedback to improve rationality and reduce numbers of test requests. Lancet. 345 (8948): 498-502. 10.1016/S0140-6736(95)90588-X. 1995 Feb 25
25.
go back to reference Weijden van der, Wensing M, Giffel M, Winkens R, Grol R: Interventions aimed at influencing the use of diagnostic tests. Report. 2000, Maastricht University: centre for Quality of Care Research (WOK) Weijden van der, Wensing M, Giffel M, Winkens R, Grol R: Interventions aimed at influencing the use of diagnostic tests. Report. 2000, Maastricht University: centre for Quality of Care Research (WOK)
26.
go back to reference Eccles M, Steen N, Grimshaw J, Thomas L, McNamee P, Soutter J, Wilsdon J, Matowe L, Needham G, Gilbert F, Bond S: Effect of audit and feedback, and reminder messages on primary-care radiology referrals: a randomised trial. Lancet. 357 (9266): 1406-9. 10.1016/S0140-6736(00)04564-5. 2001 May 5 Eccles M, Steen N, Grimshaw J, Thomas L, McNamee P, Soutter J, Wilsdon J, Matowe L, Needham G, Gilbert F, Bond S: Effect of audit and feedback, and reminder messages on primary-care radiology referrals: a randomised trial. Lancet. 357 (9266): 1406-9. 10.1016/S0140-6736(00)04564-5. 2001 May 5
27.
go back to reference Mason J, Freemantle N, Nazareth I, Eccles M, Haines A, Drummond M: When is it cost-effective to change the behavior of health professionals?. JAMA. 286 (23): 2988-92. 10.1001/jama.286.23.2988. 2001 Dec 19 Mason J, Freemantle N, Nazareth I, Eccles M, Haines A, Drummond M: When is it cost-effective to change the behavior of health professionals?. JAMA. 286 (23): 2988-92. 10.1001/jama.286.23.2988. 2001 Dec 19
28.
go back to reference Sculpher M: Evaluating the cost-effectiveness of interventions designed to increase the utilization of evidence-based guidelines. Fam Pract. 2000, 17 (Suppl 1): S26-31. 10.1093/fampra/17.suppl_1.S26.CrossRef Sculpher M: Evaluating the cost-effectiveness of interventions designed to increase the utilization of evidence-based guidelines. Fam Pract. 2000, 17 (Suppl 1): S26-31. 10.1093/fampra/17.suppl_1.S26.CrossRef
29.
go back to reference Severens JL: Value for money of changing healthcare services? Economic evaluation of quality improvement. Qual Saf Health Care. 2003, 12: 366-371. 10.1136/qhc.12.5.366.CrossRef Severens JL: Value for money of changing healthcare services? Economic evaluation of quality improvement. Qual Saf Health Care. 2003, 12: 366-371. 10.1136/qhc.12.5.366.CrossRef
30.
go back to reference Eccles M, Mason J: How to develop cost-conscious guidelines. Health Technol Assess. 2001, 5 (16): 1-69.CrossRef Eccles M, Mason J: How to develop cost-conscious guidelines. Health Technol Assess. 2001, 5 (16): 1-69.CrossRef
Metadata
Title
Does a joint development and dissemination of multidisciplinary guidelines improve prescribing behaviour: a pre/post study with concurrent control group and a randomised trial
Authors
Jody D Martens
Ron AG Winkens
Trudy van der Weijden
Daisy de Bruyn
Johan L Severens
Publication date
01-12-2006
Publisher
BioMed Central
Published in
BMC Health Services Research / Issue 1/2006
Electronic ISSN: 1472-6963
DOI
https://doi.org/10.1186/1472-6963-6-145

Other articles of this Issue 1/2006

BMC Health Services Research 1/2006 Go to the issue