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Published in: BMC Health Services Research 1/2014

Open Access 01-12-2014 | Research article

Feasibility of sustainable provision of intradermal post exposure prophylaxis against rabies at primary care level –evidence from rural Haryana

Authors: Harshal Salve, Sanjeev Kumar, Rizwan SA, Sanjay K Rai, Shashi Kant, Chandrakant S Pandav

Published in: BMC Health Services Research | Issue 1/2014

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Abstract

Background

Rabies is the most severe and neglected public health problem in India. Management of animal bite with post exposure prophylaxis is the only existent strategy to prevent rabies related deaths. Cost-effective and sustainable programme for provision of post exposure prophylaxis (PEP) is needed in India.

Methods

In this study, we have documented the experience of implementation of intra-dermal anti rabies vaccination in Animal Bite Management (ABM) clinic at Primary Health Centre (PHC). This study facility belonged to Comprehensive Rural Health Services Project, Ballabgarh in Faridabad district of Haryana. Hospital service record of ABM clinic was analyzed and various feasibility issues such as costing of services, vaccine wastage and other operational issues in providing PEP services at PHC level were documented.

Results

A total of 619 patients were treated in the ABM clinic. Service utilization of ABM clinic was increased by 38% in the second year of implementation. Mean age of the patients was 23.9 years (SD: 18.8) and majority (70.4%) were males. Majority (86%) of the patients received the first dose of anti-rabies vaccine within the recommended 48 hours. A total 446 vaccine vials (1 ml) were consumed of which 20.8% was contributed in vaccine wastage. User-fee (350 Indian Rupees) collected from the patients. User-fee was re-used to purchase vaccines, intradermal (ID) syringes and other consumables required to ensure regular availability of ARV services at the PHC.

Conclusions

This study demonstrated the cost-effective and sustainable model of provision of PEP against rabies at primary care level. ID PEP provision at primary care level not only address the unmet need of animal bite management in the community also reduces the out of pocket expenditure of the patients.
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Literature
1.
go back to reference Tomasiewicz K, Fota-Markowska H, Krzowska-Firych J, Krawczuk G: Post-exposure anti-rabies prophylaxis in Lublin province (eastern poland) in 2004-2005. Ann Agric Environ Med. 2006, 13: 337-340.PubMed Tomasiewicz K, Fota-Markowska H, Krzowska-Firych J, Krawczuk G: Post-exposure anti-rabies prophylaxis in Lublin province (eastern poland) in 2004-2005. Ann Agric Environ Med. 2006, 13: 337-340.PubMed
2.
go back to reference Sudarshan MK, Mahendra BJ, Madhusudana SN, Ashwoath Narayana DH, Rahman A, Rao NS, X-Meslin F, Lobo D, Ravikumar K, Gangaboraiah : An epidemiological study of animal bites in India: results of a WHO sponsored national multi-centric rabies survey. J Commun Dis. 2006, 38 (1): 32-39.PubMed Sudarshan MK, Mahendra BJ, Madhusudana SN, Ashwoath Narayana DH, Rahman A, Rao NS, X-Meslin F, Lobo D, Ravikumar K, Gangaboraiah : An epidemiological study of animal bites in India: results of a WHO sponsored national multi-centric rabies survey. J Commun Dis. 2006, 38 (1): 32-39.PubMed
3.
go back to reference Franka R, Wu XF, Jackson FR, Velasco-Villa A, Palmer DP, Henderson H, Hayat W, Green DB, Blanton JD, Greenberg L, Rupprecht CE: Rabies virus pathogenesis in relationship to intervention with inactivated and attenuated rabies vaccines. Vaccine. 2009, 27: 7149-7155. 10.1016/j.vaccine.2009.09.034.CrossRefPubMed Franka R, Wu XF, Jackson FR, Velasco-Villa A, Palmer DP, Henderson H, Hayat W, Green DB, Blanton JD, Greenberg L, Rupprecht CE: Rabies virus pathogenesis in relationship to intervention with inactivated and attenuated rabies vaccines. Vaccine. 2009, 27: 7149-7155. 10.1016/j.vaccine.2009.09.034.CrossRefPubMed
5.
go back to reference Knobel DL, Cleaveland S, Coleman PG, Fevre EM, Meltzer MI, Miranda ME, Shaw A, Zinsstag J, Meslin FX: Re-evaluating the burden of rabies in Africa and Asia. Bull World Health Organ. 2005, 83: 360-368.PubMedPubMedCentral Knobel DL, Cleaveland S, Coleman PG, Fevre EM, Meltzer MI, Miranda ME, Shaw A, Zinsstag J, Meslin FX: Re-evaluating the burden of rabies in Africa and Asia. Bull World Health Organ. 2005, 83: 360-368.PubMedPubMedCentral
6.
go back to reference Muller T, Dietzschold B, Ertl H, Fooks AR, Freuling C, Fehlner-Gardiner C, Kliemt J, Meslin FX, Franka R, Rupprecht CE, Tordo N, Wanderler AI, Kieny MP: Development of a mouse monoclonal antibody cocktail for post-exposure rabies prophylaxis in humans. PLoS Negl Trop Dis. 2009, 3: e542-10.1371/journal.pntd.0000542.CrossRefPubMedPubMedCentral Muller T, Dietzschold B, Ertl H, Fooks AR, Freuling C, Fehlner-Gardiner C, Kliemt J, Meslin FX, Franka R, Rupprecht CE, Tordo N, Wanderler AI, Kieny MP: Development of a mouse monoclonal antibody cocktail for post-exposure rabies prophylaxis in humans. PLoS Negl Trop Dis. 2009, 3: e542-10.1371/journal.pntd.0000542.CrossRefPubMedPubMedCentral
7.
go back to reference Ly S, Buchy P, Heng NY, Ong S, Chhor N, Bourhy H, Vong S: Rabies Situation in Cambodia. PLoS Negl Trop Dis. 2009, 3: e511-10.1371/journal.pntd.0000511. doi:510.1371/journal.pntd.0000511CrossRefPubMedPubMedCentral Ly S, Buchy P, Heng NY, Ong S, Chhor N, Bourhy H, Vong S: Rabies Situation in Cambodia. PLoS Negl Trop Dis. 2009, 3: e511-10.1371/journal.pntd.0000511. doi:510.1371/journal.pntd.0000511CrossRefPubMedPubMedCentral
8.
go back to reference The Asian Rabies Expert Bureau Preventing the incurable: Asian rabies experts advocate rabies control. Vaccine. 2006, 24: 3045-3049. 10.1016/j.vaccine.2005.10.015.CrossRef The Asian Rabies Expert Bureau Preventing the incurable: Asian rabies experts advocate rabies control. Vaccine. 2006, 24: 3045-3049. 10.1016/j.vaccine.2005.10.015.CrossRef
9.
go back to reference Hampson K, Dobson A, Kaare M, Dushoff J, Magoto M, Sindoya E, Cleaveland S: Rabies exposures, post-exposure prophylaxis and deaths in a region of endemic canine rabies. PLoS Negl Trop Dis. 2008, 2: e339-10.1371/journal.pntd.0000339.CrossRefPubMedPubMedCentral Hampson K, Dobson A, Kaare M, Dushoff J, Magoto M, Sindoya E, Cleaveland S: Rabies exposures, post-exposure prophylaxis and deaths in a region of endemic canine rabies. PLoS Negl Trop Dis. 2008, 2: e339-10.1371/journal.pntd.0000339.CrossRefPubMedPubMedCentral
11.
go back to reference Hampson K, Cleaveland S, Briggs D: Evaluation of Cost-Effective Strategies for Rabies Post-Exposure Vaccination in Low-Income Countries. PLoS Negl Trop Dis. 2011, 5 (3): e982-10.1371/journal.pntd.0000982. doi:10.1371/journal.pntd.0000982CrossRefPubMedPubMedCentral Hampson K, Cleaveland S, Briggs D: Evaluation of Cost-Effective Strategies for Rabies Post-Exposure Vaccination in Low-Income Countries. PLoS Negl Trop Dis. 2011, 5 (3): e982-10.1371/journal.pntd.0000982. doi:10.1371/journal.pntd.0000982CrossRefPubMedPubMedCentral
13.
go back to reference National Rural Health Mission: Implementation Guidelines New Delhi: Ministry of Health and Family Welfare, Government of India. 2005, Available at http://nrhm.gov.in/ [Accessed on 21 September 21, 2013] National Rural Health Mission: Implementation Guidelines New Delhi: Ministry of Health and Family Welfare, Government of India. 2005, Available at http://​nrhm.​gov.​in/​ [Accessed on 21 September 21, 2013]
14.
go back to reference Kant S, Misra P, Gupta S, Goswami K, Krishnan A, Nongkynrih B, Rai SK, Srivastava R, Pandav CS: Cohort Profile: The Ballabgarh Health and Demographic Surveillance System (CRHSP-AIIMS). Int J Epidemiol. 2013, doi:10.1093/ije/dyt055 [Epub ahead of print] Kant S, Misra P, Gupta S, Goswami K, Krishnan A, Nongkynrih B, Rai SK, Srivastava R, Pandav CS: Cohort Profile: The Ballabgarh Health and Demographic Surveillance System (CRHSP-AIIMS). Int J Epidemiol. 2013, doi:10.1093/ije/dyt055 [Epub ahead of print]
15.
go back to reference Kulkarni PS, Raut SK, Jadhav SS, Kapre SV, Deuskar N: Immunogenicity of two modern tissue culture rabies vaccines in pre-exposure prophylaxis. Hum Vaccine. 2007, 3 (5): 183-186. 10.4161/hv.3.5.4360.CrossRef Kulkarni PS, Raut SK, Jadhav SS, Kapre SV, Deuskar N: Immunogenicity of two modern tissue culture rabies vaccines in pre-exposure prophylaxis. Hum Vaccine. 2007, 3 (5): 183-186. 10.4161/hv.3.5.4360.CrossRef
16.
go back to reference Chhabra M, Icchpujani RL, Bhardwaj M, Tiwari KN, Panda RC, Lal S: Safety and immunogenicity of intradermal Thi Red Cross (2-2-2-0-1-1) post exposure vaccination regimen in the Indian population using Purified Chick Embryo Cell Rabies vaccine. Indian J Med Microbiol. 2005, 23 (1): 24-28. 10.4103/0255-0857.13868.CrossRefPubMed Chhabra M, Icchpujani RL, Bhardwaj M, Tiwari KN, Panda RC, Lal S: Safety and immunogenicity of intradermal Thi Red Cross (2-2-2-0-1-1) post exposure vaccination regimen in the Indian population using Purified Chick Embryo Cell Rabies vaccine. Indian J Med Microbiol. 2005, 23 (1): 24-28. 10.4103/0255-0857.13868.CrossRefPubMed
17.
go back to reference Madhusudana SN, Sanjay TV, Mahendra BJ, Sudarshan MK, Narayana DH, Giri A, Muhamuda K, Ravi V, Vakil HB, Malerczyk C: Comparison of safety and immunogenicity of purified chick embryo cell rabies vaccine (PCECV) and purified vero cell rabies vaccine (PVRV) using the Thai Red Cross intradermal regimen at a dose of 0.1 ML. Hum Vaccine. 2006, 2: 200-204. 10.4161/hv.2.5.3197.CrossRef Madhusudana SN, Sanjay TV, Mahendra BJ, Sudarshan MK, Narayana DH, Giri A, Muhamuda K, Ravi V, Vakil HB, Malerczyk C: Comparison of safety and immunogenicity of purified chick embryo cell rabies vaccine (PCECV) and purified vero cell rabies vaccine (PVRV) using the Thai Red Cross intradermal regimen at a dose of 0.1 ML. Hum Vaccine. 2006, 2: 200-204. 10.4161/hv.2.5.3197.CrossRef
18.
go back to reference Sekhri N, Savedoff W: Private health insurance: implications for developing countries. Bull World Health Organ. 2005, 83: 127-134.PubMedPubMedCentral Sekhri N, Savedoff W: Private health insurance: implications for developing countries. Bull World Health Organ. 2005, 83: 127-134.PubMedPubMedCentral
19.
go back to reference Rasania SK, Bhalla S, Khandekar J, Pathi S, Matta S, Singh S: Post exposure management of animal bite cases attending a primary health centers of Delhi. J Commun Dis. 2004, 36 (3): 195-198.PubMed Rasania SK, Bhalla S, Khandekar J, Pathi S, Matta S, Singh S: Post exposure management of animal bite cases attending a primary health centers of Delhi. J Commun Dis. 2004, 36 (3): 195-198.PubMed
20.
go back to reference Shankar P, Arun Kumar A, Rajesh K: Panos Kanavos user-fee in health care: evidence of effect on service utilization & equity from north India. Indian J Med Res. 2012, 136: 868-876. Shankar P, Arun Kumar A, Rajesh K: Panos Kanavos user-fee in health care: evidence of effect on service utilization & equity from north India. Indian J Med Res. 2012, 136: 868-876.
Metadata
Title
Feasibility of sustainable provision of intradermal post exposure prophylaxis against rabies at primary care level –evidence from rural Haryana
Authors
Harshal Salve
Sanjeev Kumar
Rizwan SA
Sanjay K Rai
Shashi Kant
Chandrakant S Pandav
Publication date
01-12-2014
Publisher
BioMed Central
Published in
BMC Health Services Research / Issue 1/2014
Electronic ISSN: 1472-6963
DOI
https://doi.org/10.1186/1472-6963-14-278

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