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BMC Health Services Research
Published in: BMC Health Services Research 1/2011

Open Access 01-12-2011 | Research article

A randomized trial of an intervention to improve use and adherence to effective coronary heart disease prevention strategies

Authors: Stacey L Sheridan, Lindy B Draeger, Michael P Pignone, Thomas C Keyserling, Ross J Simpson Jr, Barbara Rimer, Shrikant I Bangdiwala, Jianwen Cai, Ziya Gizlice

Published in: BMC Health Services Research | Issue 1/2011

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Abstract

Background

Efficacious strategies for the primary prevention of coronary heart disease (CHD) are underused, and, when used, have low adherence. Existing efforts to improve use and adherence to these efficacious strategies have been so intensive that they are impractical for clinical practice.

Methods

We conducted a randomized trial of a CHD prevention intervention (including a computerized decision aid and automated tailored adherence messages) at one university general internal medicine practice. After obtaining informed consent and collecting baseline data, we randomized patients (men and women age 40-79 with no prior history of cardiovascular disease) to either the intervention or usual care. We then saw them for two additional study visits over 3 months. For intervention participants, we administered the decision aid at the primary study visit (1 week after baseline visit) and then mailed 3 tailored adherence reminders at 2, 4, and 6 weeks. We assessed our outcomes (including the predicted likelihood of angina, myocardial infarction, and CHD death over 10 years (CHD risk) and self-reported adherence) between groups at 3 month follow-up. Data collection occurred from June 2007 through December 2009. All study procedures were IRB approved.

Results

We randomized 160 eligible patients (81 intervention; 79 control) and followed 96% to study conclusion. Mean predicted CHD risk at baseline was 11.3%. The intervention increased self-reported adherence to chosen risk reducing strategies by 25 percentage points (95% CI 8% to 42%), with the biggest effect for aspirin. It also changed predicted CHD risk by -1.1% (95% CI -0.16% to -2%), with a larger effect in a pre-specified subgroup of high risk patients.

Conclusion

A computerized intervention that involves patients in CHD decision making and supports adherence to effective prevention strategies can improve adherence and reduce predicted CHD risk.

Clinical trials registration number

ClinicalTrials.gov: NCT00494052
Appendix
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Metadata
Title
A randomized trial of an intervention to improve use and adherence to effective coronary heart disease prevention strategies
Authors
Stacey L Sheridan
Lindy B Draeger
Michael P Pignone
Thomas C Keyserling
Ross J Simpson Jr
Barbara Rimer
Shrikant I Bangdiwala
Jianwen Cai
Ziya Gizlice
Publication date
01-12-2011
Publisher
BioMed Central
Published in
BMC Health Services Research / Issue 1/2011
Electronic ISSN: 1472-6963
DOI
https://doi.org/10.1186/1472-6963-11-331

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