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Published in: BMC Medical Informatics and Decision Making 1/2013

Open Access 01-12-2013 | Research article

Global informetric perspective studies on translational medical research

Authors: Qiang Yao, Peng-Hui Lyu, Fei-Cheng Ma, Lan Yao, Shi-Jing Zhang

Published in: BMC Medical Informatics and Decision Making | Issue 1/2013

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Abstract

Background

Translational medical research literature has increased rapidly in the last few decades and played a more and more important role during the development of medicine science. The main aim of this study is to evaluate the global performance of translational medical research during the past few decades.

Methods

Bibliometric, social network analysis, and visualization technologies were used for analyzing translational medical research performance from the aspects of subject categories, journals, countries, institutes, keywords, and MeSH terms. Meanwhile, the co-author, co-words and cluster analysis methods were also used to trace popular topics in translational medical research related work.

Results

Research output suggested a solid development in translational medical research, in terms of increasing scientific production and research collaboration. We identified the core journals, mainstream subject categories, leading countries, and institutions in translational medical research. There was an uneven distribution of publications at authorial, institutional, and national levels. The most commonly used keywords that appeared in the articles were “translational research”, “translational medicine”, “biomarkers”, “stroke”, “inflammation”, “cancer”, and “breast cancer”.

Conclusions

The subject categories of “Research & Experimental Medicine”, “Medical Laboratory Technology”, and “General & Internal Medicine” play a key role in translational medical research both in production and in its networks. Translational medical research and CTS, etc. are core journals of translational research. G7 countries are the leading nations for translational medical research. Some developing countries, such as P.R China, also play an important role in the communication of translational research. The USA and its institutions play a dominant role in the production, collaboration, citations and high quality articles. The research trends in translational medical research involve drug design and development, pathogenesis and treatment of disease, disease model research, evidence-based research, and stem and progenitor cells.
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Literature
2.
go back to reference Zerhouni EA: Clinical research at a crossroads: the NIH roadmap. J Invest Med. 2006, 54 (4): 171-173. 10.2310/6650.2006.X0016.CrossRef Zerhouni EA: Clinical research at a crossroads: the NIH roadmap. J Invest Med. 2006, 54 (4): 171-173. 10.2310/6650.2006.X0016.CrossRef
4.
go back to reference MeSH browser (2013 MeSH). 2013, Available at http://www.nlm.nih.gov/mesh/2013/mesh_browser/MBrowser.html (last accessed 23 May 2013) MeSH browser (2013 MeSH). 2013, Available at http://​www.​nlm.​nih.​gov/​mesh/​2013/​mesh_​browser/​MBrowser.​html (last accessed 23 May 2013)
5.
go back to reference Mischel PS: American society for clinical investigation presidential address lost - and found - in translation. J Clin Invest. 2011, 121 (8): 3357-3359. 10.1172/JCI59686.CrossRefPubMedPubMedCentral Mischel PS: American society for clinical investigation presidential address lost - and found - in translation. J Clin Invest. 2011, 121 (8): 3357-3359. 10.1172/JCI59686.CrossRefPubMedPubMedCentral
6.
go back to reference Sung NS, Crowley WF, Genel M, Salber P, Sandy L, Sherwood LM, Johnson SB, Catanese V, Tilson H, Getz K: Central challenges facing the national clinical research enterprise. JAMA. 2003, 289 (10): 1278-1287. 10.1001/jama.289.10.1278.CrossRefPubMed Sung NS, Crowley WF, Genel M, Salber P, Sandy L, Sherwood LM, Johnson SB, Catanese V, Tilson H, Getz K: Central challenges facing the national clinical research enterprise. JAMA. 2003, 289 (10): 1278-1287. 10.1001/jama.289.10.1278.CrossRefPubMed
7.
go back to reference Westfall JM, Mold J, Fagnan L: Practice-based research–“Blue Highways” on the NIH roadmap. JAMA. 2007, 297 (4): 403-406. 10.1001/jama.297.4.403.CrossRefPubMed Westfall JM, Mold J, Fagnan L: Practice-based research–“Blue Highways” on the NIH roadmap. JAMA. 2007, 297 (4): 403-406. 10.1001/jama.297.4.403.CrossRefPubMed
8.
go back to reference Drolet BC, Lorenzi NM: Translational research: understanding the continuum from bench to bedside. Transl Res. 2011, 157 (1): 1-5. 10.1016/j.trsl.2010.10.002.CrossRefPubMed Drolet BC, Lorenzi NM: Translational research: understanding the continuum from bench to bedside. Transl Res. 2011, 157 (1): 1-5. 10.1016/j.trsl.2010.10.002.CrossRefPubMed
9.
go back to reference Dougherty D, Conway PH: The “3T’s” road map to transform US health care: the “how” of high-quality care. JAMA. 2008, 299 (19): 2319-2321. 10.1001/jama.299.19.2319.CrossRefPubMed Dougherty D, Conway PH: The “3T’s” road map to transform US health care: the “how” of high-quality care. JAMA. 2008, 299 (19): 2319-2321. 10.1001/jama.299.19.2319.CrossRefPubMed
10.
go back to reference Rubio DM, Schoenbaum EE, Lee LS, Schteingart DE, Marantz PR, Anderson KE, Platt LD, Baez A, Esposito K: Defining translational research: implications for training. Acad Med. 2010, 85 (3): 470-475. 10.1097/ACM.0b013e3181ccd618.CrossRefPubMedPubMedCentral Rubio DM, Schoenbaum EE, Lee LS, Schteingart DE, Marantz PR, Anderson KE, Platt LD, Baez A, Esposito K: Defining translational research: implications for training. Acad Med. 2010, 85 (3): 470-475. 10.1097/ACM.0b013e3181ccd618.CrossRefPubMedPubMedCentral
11.
go back to reference Li G, Miao R, Zhao H: Progression and prospects of translational medicine in China. Sci China Life Sci. 2012, 55 (11): 1022-1025. 10.1007/s11427-012-4397-5.CrossRefPubMed Li G, Miao R, Zhao H: Progression and prospects of translational medicine in China. Sci China Life Sci. 2012, 55 (11): 1022-1025. 10.1007/s11427-012-4397-5.CrossRefPubMed
12.
go back to reference Godfraind T: Traditional and translational medicine. Bull Acad Natl Med. 2007, 191 (4–5): 715-725.PubMed Godfraind T: Traditional and translational medicine. Bull Acad Natl Med. 2007, 191 (4–5): 715-725.PubMed
13.
go back to reference Brander C, Ferrone S, Marincola FM: Rewarding patient-directed research: excellence in translational medicine award. J Transl Med. 2006, 4: 19-10.1186/1479-5876-4-19.CrossRefPubMedCentral Brander C, Ferrone S, Marincola FM: Rewarding patient-directed research: excellence in translational medicine award. J Transl Med. 2006, 4: 19-10.1186/1479-5876-4-19.CrossRefPubMedCentral
14.
go back to reference Woolf SH: The meaning of translational research and why it matters. JAMA. 2008, 299 (2): 211-213. 10.1001/jama.2007.26.CrossRefPubMed Woolf SH: The meaning of translational research and why it matters. JAMA. 2008, 299 (2): 211-213. 10.1001/jama.2007.26.CrossRefPubMed
15.
go back to reference Wehling M: Drug development in the light of translational science: shine or shade?. Drug Discov Today. 2011, 16 (23–24): 1076-1083.CrossRefPubMed Wehling M: Drug development in the light of translational science: shine or shade?. Drug Discov Today. 2011, 16 (23–24): 1076-1083.CrossRefPubMed
16.
go back to reference Tralau-Stewart CJ, Wyatt CA, Kleyn DE, Ayad A: Drug discovery: new models for industry-academic partnerships. Drug Discov Today. 2009, 14 (1–2): 95-101.CrossRefPubMed Tralau-Stewart CJ, Wyatt CA, Kleyn DE, Ayad A: Drug discovery: new models for industry-academic partnerships. Drug Discov Today. 2009, 14 (1–2): 95-101.CrossRefPubMed
17.
go back to reference The Office for Strategic Co-ordination of Health Research (OSCHR): Background on the review of health research in the UK and OSCHR 2008. 2012, Available at http://www.nihr.ac.uk/about/Pages/about_oschr.aspx (last accessed 30 October 2012) The Office for Strategic Co-ordination of Health Research (OSCHR): Background on the review of health research in the UK and OSCHR 2008. 2012, Available at http://​www.​nihr.​ac.​uk/​about/​Pages/​about_​oschr.​aspx (last accessed 30 October 2012)
18.
go back to reference Su HN, Lee PC: Mapping knowledge structure by keyword co-occurrence: a first look at journal papers in technology foresight. Scientometrics. 2010, 85 (1): 65-79. 10.1007/s11192-010-0259-8.CrossRef Su HN, Lee PC: Mapping knowledge structure by keyword co-occurrence: a first look at journal papers in technology foresight. Scientometrics. 2010, 85 (1): 65-79. 10.1007/s11192-010-0259-8.CrossRef
19.
go back to reference Garfield E: Citation indexing for studying science. Nature. 1970, 227 (5259): 669-671. 10.1038/227669a0.CrossRefPubMed Garfield E: Citation indexing for studying science. Nature. 1970, 227 (5259): 669-671. 10.1038/227669a0.CrossRefPubMed
20.
go back to reference Enachescu C, Postelnicu T: Patterns in journal citation data revealed by exploratory multivariate analysis. Scientometrics. 2003, 56 (1): 43-59. 10.1023/A:1021946506987.CrossRef Enachescu C, Postelnicu T: Patterns in journal citation data revealed by exploratory multivariate analysis. Scientometrics. 2003, 56 (1): 43-59. 10.1023/A:1021946506987.CrossRef
21.
go back to reference Faba-Perez C, Guerrero-Bote VP, De Moya-Anegon F: Data mining in a closed Web environment. Scientometrics. 2003, 58 (3): 623-640.CrossRef Faba-Perez C, Guerrero-Bote VP, De Moya-Anegon F: Data mining in a closed Web environment. Scientometrics. 2003, 58 (3): 623-640.CrossRef
22.
go back to reference Boyack KW, Klavans R, Borner K: Mapping the backbone of science. Scientometrics. 2005, 64 (3): 351-374. 10.1007/s11192-005-0255-6.CrossRef Boyack KW, Klavans R, Borner K: Mapping the backbone of science. Scientometrics. 2005, 64 (3): 351-374. 10.1007/s11192-005-0255-6.CrossRef
23.
go back to reference Chen W, Chen S, Qi DC, Gao XY, Wee ATS: Surface transfer p-type doping of epitaxial graphene. J Am Chem Soc. 2007, 129 (34): 10418-10422. 10.1021/ja071658g.CrossRefPubMed Chen W, Chen S, Qi DC, Gao XY, Wee ATS: Surface transfer p-type doping of epitaxial graphene. J Am Chem Soc. 2007, 129 (34): 10418-10422. 10.1021/ja071658g.CrossRefPubMed
24.
go back to reference Pouris A, Pouris A: Scientometrics of a pandemic: HIV/AIDS research in South Africa and the world. Scientometrics. 2011, 86 (2): 541-552. 10.1007/s11192-010-0277-6.CrossRef Pouris A, Pouris A: Scientometrics of a pandemic: HIV/AIDS research in South Africa and the world. Scientometrics. 2011, 86 (2): 541-552. 10.1007/s11192-010-0277-6.CrossRef
25.
go back to reference Deshazo JP, Lavallie DL, Wolf FM: Publication trends in the medical informatics literature: 20 years of “medical informatics” in MeSH. BMC Med Inform Decis Mak. 2009, 9: 7-10.1186/1472-6947-9-7.CrossRefPubMedPubMedCentral Deshazo JP, Lavallie DL, Wolf FM: Publication trends in the medical informatics literature: 20 years of “medical informatics” in MeSH. BMC Med Inform Decis Mak. 2009, 9: 7-10.1186/1472-6947-9-7.CrossRefPubMedPubMedCentral
26.
go back to reference Lavallie DL, Wolf FM: Publication trends and impact factors in the medical informatics literature. AMIA Annu Symp Proc. 2005, 2005: 1018-PubMedCentral Lavallie DL, Wolf FM: Publication trends and impact factors in the medical informatics literature. AMIA Annu Symp Proc. 2005, 2005: 1018-PubMedCentral
27.
go back to reference Pritchard A: Statistical bibliography or bibliometrics?. J Doc. 1969, 4 (25): 348-349. Pritchard A: Statistical bibliography or bibliometrics?. J Doc. 1969, 4 (25): 348-349.
28.
go back to reference Kho ME, Brouwers MC: The systematic review and bibliometric network analysis (SeBriNA) is a new method to contextualize evidence. Part 1: description. J Clin Epidemiol. 2012, 65 (9): 1010-1015. 10.1016/j.jclinepi.2012.03.009.CrossRefPubMed Kho ME, Brouwers MC: The systematic review and bibliometric network analysis (SeBriNA) is a new method to contextualize evidence. Part 1: description. J Clin Epidemiol. 2012, 65 (9): 1010-1015. 10.1016/j.jclinepi.2012.03.009.CrossRefPubMed
30.
go back to reference van Eck NJ, Waltman L: Software survey: VOSviewer, a computer program for bibliometric mapping. Scientometrics. 2010, 84 (2): 523-538. 10.1007/s11192-009-0146-3.CrossRefPubMed van Eck NJ, Waltman L: Software survey: VOSviewer, a computer program for bibliometric mapping. Scientometrics. 2010, 84 (2): 523-538. 10.1007/s11192-009-0146-3.CrossRefPubMed
31.
go back to reference Wang L, Wang L, Pan YT: Research frontiers and trends in graphene research. New Carbon Mater. 2010, 25 (6): 401-408. Wang L, Wang L, Pan YT: Research frontiers and trends in graphene research. New Carbon Mater. 2010, 25 (6): 401-408.
32.
go back to reference Schneider C, Muller U, Kilper R, Siebertz B: Low copy number DNA profiling from isolated sperm using the aureka (R)-micromanipulation system. Forensic Sci Int Genet. 2012, 6 (4): 461-465. 10.1016/j.fsigen.2011.10.001.CrossRefPubMed Schneider C, Muller U, Kilper R, Siebertz B: Low copy number DNA profiling from isolated sperm using the aureka (R)-micromanipulation system. Forensic Sci Int Genet. 2012, 6 (4): 461-465. 10.1016/j.fsigen.2011.10.001.CrossRefPubMed
33.
go back to reference Mutschke P: Mining networks and central entities in digital libraries. A graph theoretic approach applied to Co-author networks: advances in intelligent data analysis V. Lect Notes Comp Sci. 2003, 2810: 155-166. 10.1007/978-3-540-45231-7_15.CrossRef Mutschke P: Mining networks and central entities in digital libraries. A graph theoretic approach applied to Co-author networks: advances in intelligent data analysis V. Lect Notes Comp Sci. 2003, 2810: 155-166. 10.1007/978-3-540-45231-7_15.CrossRef
34.
go back to reference Knapp J: What is a co-author?. Representations. 2005, 89: 1-29. 10.1525/rep.2005.89.1.1.CrossRef Knapp J: What is a co-author?. Representations. 2005, 89: 1-29. 10.1525/rep.2005.89.1.1.CrossRef
35.
go back to reference Leydesdorff L: Why words and co-words cannot map the development of the sciences. J Am Soc Inform Sci. 1997, 48 (5): 418-427. 10.1002/(SICI)1097-4571(199705)48:5<418::AID-ASI4>3.0.CO;2-Y.CrossRef Leydesdorff L: Why words and co-words cannot map the development of the sciences. J Am Soc Inform Sci. 1997, 48 (5): 418-427. 10.1002/(SICI)1097-4571(199705)48:5<418::AID-ASI4>3.0.CO;2-Y.CrossRef
36.
go back to reference Anderberg MR: Cluster analysis for applications. Office of the Assistant for Study Support Kirtland AFBN Mex. 1973 Anderberg MR: Cluster analysis for applications. Office of the Assistant for Study Support Kirtland AFBN Mex. 1973
37.
go back to reference Eisen MB, Spellman PT, Brown PO, Botstein D: Cluster analysis and display of genome-wide expression patterns. Proc Natl Acad Sci USA. 1998, 95 (25): 14863-14868. 10.1073/pnas.95.25.14863.CrossRefPubMedPubMedCentral Eisen MB, Spellman PT, Brown PO, Botstein D: Cluster analysis and display of genome-wide expression patterns. Proc Natl Acad Sci USA. 1998, 95 (25): 14863-14868. 10.1073/pnas.95.25.14863.CrossRefPubMedPubMedCentral
38.
go back to reference Ketchen DJ, Shook CL: The application of cluster analysis in strategic management research: an analysis and critique. Strateg Manag J. 1996, 17 (6): 441-458. 10.1002/(SICI)1097-0266(199606)17:6<441::AID-SMJ819>3.0.CO;2-G.CrossRef Ketchen DJ, Shook CL: The application of cluster analysis in strategic management research: an analysis and critique. Strateg Manag J. 1996, 17 (6): 441-458. 10.1002/(SICI)1097-0266(199606)17:6<441::AID-SMJ819>3.0.CO;2-G.CrossRef
39.
go back to reference Dang Y, Zhang YL, Hu PJH, Brown SA, Chen HC: Knowledge mapping for rapidly evolving domains: a design science approach. Decis Support Syst. 2011, 50 (2): 415-427. 10.1016/j.dss.2010.10.003.CrossRef Dang Y, Zhang YL, Hu PJH, Brown SA, Chen HC: Knowledge mapping for rapidly evolving domains: a design science approach. Decis Support Syst. 2011, 50 (2): 415-427. 10.1016/j.dss.2010.10.003.CrossRef
40.
go back to reference Zhang SL, Wang JP, Zhao YJ: Proceedings of the 7th national conference on Functional Materials and Applications (FMA 2010 E-BOOK). Analysis of international proprietary technology development of solid state lighting material. 2010, Changsha, China, 984-992. Zhang SL, Wang JP, Zhao YJ: Proceedings of the 7th national conference on Functional Materials and Applications (FMA 2010 E-BOOK). Analysis of international proprietary technology development of solid state lighting material. 2010, Changsha, China, 984-992.
41.
go back to reference Tinga N, De N, Vien HV, Chau L, Toan ND, Kager PA, Vries PJ: Little effect of praziquantel or artemisinin on clonorchiasis in Northern Vietnam. a pilot study. Trop Med Int Health. 1999, 4 (12): 814-818. 10.1046/j.1365-3156.1999.00499.x.CrossRefPubMed Tinga N, De N, Vien HV, Chau L, Toan ND, Kager PA, Vries PJ: Little effect of praziquantel or artemisinin on clonorchiasis in Northern Vietnam. a pilot study. Trop Med Int Health. 1999, 4 (12): 814-818. 10.1046/j.1365-3156.1999.00499.x.CrossRefPubMed
42.
go back to reference Yao Q, Chen J, Lyu PH, Zhang SJ, Ma FC, Fang JG: Knowledge map of artemisinin research in SCI and medline database. J Vector Borne Dis. 2012, 49 (4): 205-216.PubMed Yao Q, Chen J, Lyu PH, Zhang SJ, Ma FC, Fang JG: Knowledge map of artemisinin research in SCI and medline database. J Vector Borne Dis. 2012, 49 (4): 205-216.PubMed
43.
go back to reference Suk FM, Lien GS, Yu TC, Ho YS: Global trends in helicobacter pylori research from 1991 to 2008 analyzed with the science citation index expanded. Eur J Gastroenterol Hepatol. 2011, 23 (4): 295-301. 10.1097/MEG.0b013e3283457af7.CrossRefPubMed Suk FM, Lien GS, Yu TC, Ho YS: Global trends in helicobacter pylori research from 1991 to 2008 analyzed with the science citation index expanded. Eur J Gastroenterol Hepatol. 2011, 23 (4): 295-301. 10.1097/MEG.0b013e3283457af7.CrossRefPubMed
44.
go back to reference Arunachalam S, Doss MJ: Mapping international collaboration in science in Asia through coauthorship analysis. Curr Sci. 2000, 79 (5): 621-628. Arunachalam S, Doss MJ: Mapping international collaboration in science in Asia through coauthorship analysis. Curr Sci. 2000, 79 (5): 621-628.
45.
go back to reference Yarime M, Takeda Y, Kajikawa Y: Towards institutional analysis of sustainability science: a quantitative examination of the patterns of research collaboration. Sustain Sci. 2010, 5 (1): 115-125. 10.1007/s11625-009-0090-4.CrossRef Yarime M, Takeda Y, Kajikawa Y: Towards institutional analysis of sustainability science: a quantitative examination of the patterns of research collaboration. Sustain Sci. 2010, 5 (1): 115-125. 10.1007/s11625-009-0090-4.CrossRef
46.
go back to reference Lou YC, Lin HF: Estimate of global research trends and performance in family therapy in social science citation index. Scientometrics. 2012, 90 (3): 807-823. 10.1007/s11192-011-0549-9.CrossRef Lou YC, Lin HF: Estimate of global research trends and performance in family therapy in social science citation index. Scientometrics. 2012, 90 (3): 807-823. 10.1007/s11192-011-0549-9.CrossRef
47.
go back to reference Li LL, Ding GH, Feng N, Wang MH, Ho YS: Global stem cell research trend: bibliometric analysis as a tool for mapping of trends from 1991 to 2006. Scientometrics. 2009, 80 (1): 39-58. 10.1007/s11192-008-1939-5.CrossRef Li LL, Ding GH, Feng N, Wang MH, Ho YS: Global stem cell research trend: bibliometric analysis as a tool for mapping of trends from 1991 to 2006. Scientometrics. 2009, 80 (1): 39-58. 10.1007/s11192-008-1939-5.CrossRef
48.
go back to reference Garfield E: KeyWords PlusTM: ISIS breakthrough retrieval method. 1. expanding your searching power on current-contents on diskette. Current Contents. 1990, 32: 5-9. Garfield E: KeyWords PlusTM: ISIS breakthrough retrieval method. 1. expanding your searching power on current-contents on diskette. Current Contents. 1990, 32: 5-9.
Metadata
Title
Global informetric perspective studies on translational medical research
Authors
Qiang Yao
Peng-Hui Lyu
Fei-Cheng Ma
Lan Yao
Shi-Jing Zhang
Publication date
01-12-2013
Publisher
BioMed Central
Published in
BMC Medical Informatics and Decision Making / Issue 1/2013
Electronic ISSN: 1472-6947
DOI
https://doi.org/10.1186/1472-6947-13-77

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