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BMC Medical Informatics and Decision Making
Published in: BMC Medical Informatics and Decision Making 1/2012

Open Access 01-12-2012 | Research article

Combinational risk factors of metabolic syndrome identified by fuzzy neural network analysis of health-check data

Authors: Yasunori Ushida, Ryuji Kato, Kosuke Niwa, Daisuke Tanimura, Hideo Izawa, Kenji Yasui, Tomokazu Takase, Yasuko Yoshida, Mitsuo Kawase, Tsutomu Yoshida, Toyoaki Murohara, Hiroyuki Honda

Published in: BMC Medical Informatics and Decision Making | Issue 1/2012

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Abstract

Background

Lifestyle-related diseases represented by metabolic syndrome develop as results of complex interaction. By using health check-up data from two large studies collected during a long-term follow-up, we searched for risk factors associated with the development of metabolic syndrome.

Methods

In our original study, we selected 77 case subjects who developed metabolic syndrome during the follow-up and 152 healthy control subjects who were free of lifestyle-related risk components from among 1803 Japanese male employees. In a replication study, we selected 2196 case subjects and 2196 healthy control subjects from among 31343 other Japanese male employees. By means of a bioinformatics approach using a fuzzy neural network (FNN), we searched any significant combinations that are associated with MetS. To ensure that the risk combination selected by FNN analysis was statistically reliable, we performed logistic regression analysis including adjustment.

Results

We selected a combination of an elevated level of γ-glutamyltranspeptidase (γ-GTP) and an elevated white blood cell (WBC) count as the most significant combination of risk factors for the development of metabolic syndrome. The FNN also identified the same tendency in a replication study. The clinical characteristics of γ-GTP level and WBC count were statistically significant even after adjustment, confirming that the results obtained from the fuzzy neural network are reasonable. Correlation ratio showed that an elevated level of γ-GTP is associated with habitual drinking of alcohol and a high WBC count is associated with habitual smoking.

Conclusions

This result obtained by fuzzy neural network analysis of health check-up data from large long-term studies can be useful in providing a personalized novel diagnostic and therapeutic method involving the γ-GTP level and the WBC count.
Appendix
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Metadata
Title
Combinational risk factors of metabolic syndrome identified by fuzzy neural network analysis of health-check data
Authors
Yasunori Ushida
Ryuji Kato
Kosuke Niwa
Daisuke Tanimura
Hideo Izawa
Kenji Yasui
Tomokazu Takase
Yasuko Yoshida
Mitsuo Kawase
Tsutomu Yoshida
Toyoaki Murohara
Hiroyuki Honda
Publication date
01-12-2012
Publisher
BioMed Central
Published in
BMC Medical Informatics and Decision Making / Issue 1/2012
Electronic ISSN: 1472-6947
DOI
https://doi.org/10.1186/1472-6947-12-80

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