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BMC Complementary Medicine and Therapies

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Open Access 01-12-2003 | Research article

Aphrodisiac activity of 50% ethanolic extracts of Myristica fragrans Houtt. (nutmeg) and Syzygium aromaticum (L) Merr. & Perry. (clove) in male mice: a comparative study

Authors: Tajuddin, Shamshad Ahmad, Abdul Latif, Iqbal Ahmad Qasmi

Published in: BMC Complementary Medicine and Therapies | Issue 1/2003

Abstract

Background

Spices are considered as sexual invigorators in the Unani System of Medicine. In order to explore the sexual function improving effect of Myristica fragrans Houtt. (nutmeg) and Syzygium aromaticum (L) Merr. & Perry. (clove) an experimental study was conducted in normal male mice.

Methods

The extracts (50% ethanolic) of nutmeg and clove were administered (500 mg/kg; p.o.) to different groups of male Swiss mice. Mounting behaviour, mating performance, and general short term toxicity of the test drugs were determined and compared with the standard drug Penegra (Sildenafil citrate).

Results

The extracts of the nutmeg and clove were found to stimulate the mounting behaviour of male mice, and also to significantly increase their mating performance. The drugs were devoid of any conspicuous general short term toxicity.

Conclusion

The extracts (50% ethanolic) of nutmeg and clove enhanced the sexual behaviour of male mice.

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Khan MA: Akseer-e-Azam. 1886, Kanpur, India. Matba Nizami, 3: 563-

Anonymous: The wealth of India. 1962, Raw materials, C.S.I.R., New Delhi, India, 4: 474-479.

Gils CV, Cox PA: Ethnobatany of nutmeg in the spice islands. Journal of Ethnopharmacology. 1994, 117-124. 10.1016/0378-8741(94)90105-8.

Gernard J: The Herball. 1597, London, 1537-1

Burkil IH: Dictionary of the Economic Products of the Malay Peninsula. 1935, London, England, 1Z Crown Agents, 2: 1554-1556. 2

Ghani N: Khazeenatul Advia. 1921, Lucknow, India. Matba Munshi Nawal Kishore, 2: 241-242. I

Khory RN, Katrak NN: Materia Medica of India and their therapeutics. 1985, Delhi, India. Neeraj Publishing House, 532-524.

Chopra RN, Chopra IC, Handa KL, Kapur LD: Indigenous Drugs of India. 1958, Calcutta, India. UN Dhur and Sons Pvt. Ltd, 201-2

Ainslie W: Materia Indica. 1979, Delhi, India. Neeraj Publishin House, 1: 249-252.

10.

Antaki DZ: Tazkirah-ulil-Albab. 1930, Cairo, Egypt. Matba Aamirah Sharfyyah, 1: 208-2

11.

Lindley J: Flora Medica. 1981, New Delhi, India. Ajay Book Service, 22-

12.

Samir Yahia EL-Gammal: Spices Throughout History. Hamdard Medicus. 1993, 1: 25-52.

13.

Isogai A, Suzuki A, Tamura S: Structure of dimeric phenoxypropanoids from Myristica fragrans. Agar Biol Chem. 1973, 37: 193-194.

14.

Khan MA: Moheet-e-Azam. 1893, Kanpur, India. Matba Nizami, 3: 296-

15.

Baytar Ibn: Kitabul Jame' Li-Mufradat il Advia wal aghzia. 1869, Cairo, Egypt. Matba Zahiyah Zaaherah Mutawafferah, 5: 7-9.

16.

Nadkarni KM: Indian Materia Medica. 1982, Bombay, India. Popular Book Depot, 1: 835-837.

17.

Attar HZ: Ikhtiyarat-e-badiyee. 1370, Lucknow, India. Munshi Nawal Kishore, 381-

18.

Nooruddin MA: Alfazal-Advia. Lucknow, India. Matba nami Munshi Nawal Kishore, 1038 H-

19.

Sina Ibn: Al Qanoon Ft Tibb. 1906, Lucknow, India. naeemi Press, 2: 154-

20.

Trease GE, Evans WC: A Text Book of Pharmacognosy. 1972, London, England, Bailliere, Tindall and Cassell, 382-10

21.

Khan HA: Majma'ul Bahrain. 1877, Lucknow, India. Matba Aali, 163-2

22.

Rastogi RP, Mehrotra BN: Compendium of Indian Medicinal Plants. 1960, New Delhi, India, 2: 477-

23.

Hubul Ibn: Kitabul Mukhtarat Fit Tibb. 1962, Hyderabad, India. Daeratul Ma'arif, 2: 221-

24.

Dhawan BN: Lectures: UNESCO-CDRI Workshop on the use of Pharmacological Techniques for Evaluation of Natural Products. 1982, Lucknow, India. Central Drug Research Institute, 61-

25.

Lawler LJ: Ethnobotany of the Orchidaceace. In: Orchid Biology: Review and Perspectives-3. Edited by: Arditti J. 1984, Ithaca, Cornell University Press, 27-149.

26.

Ecksterin P, Zukerman S: Marshall's Physiology of Reproduction. In: Part I. Edited by: Parker AS. 1960, Harlow, England. Longman Group Ltd, 1: 1-92.

27.

Suresh Kumar PK, Subramoniam A, Pushpangadan P: Aphrodisiae activity of Vanda tessella (ROXB.) HOOk. EXDON extract in male mice. Indian Journal of Pharmacology. 2000, 32: 300-304.

The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1472-6882/3/6/prepub

Title: Aphrodisiac activity of 50% ethanolic extracts of Myristica fragrans Houtt. (nutmeg) and Syzygium aromaticum (L) Merr. & Perry. (clove) in male mice: a comparative study
Authors: Tajuddin
Shamshad Ahmad
Abdul Latif
Iqbal Ahmad Qasmi
Publication date: 01-12-2003
Publisher: BioMed Central
Published in: BMC Complementary Medicine and Therapies / Issue 1/2003
Electronic ISSN: 2662-7671
DOI: https://doi.org/10.1186/1472-6882-3-6

At a glance: The STEP trials

Springer Medicine

Aphrodisiac activity of 50% ethanolic extracts of Myristica fragrans Houtt. (nutmeg) and Syzygium aromaticum (L) Merr. & Perry. (clove) in male mice: a comparative study

Abstract

Background

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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