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BMC Women's Health
Published in: BMC Women's Health 1/2002

Open Access 01-12-2002 | Research article

Effects of long-term moderate exercise and increase in number of daily steps on serum lipids in women: randomised controlled trial [ISRCTN21921919]

Authors: Hiroko Sugiura, Haruo Sugiura, Kazue Kajima, Seyed Mohammad Mirbod, Hirotoshi Iwata, Toshio Matsuoka

Published in: BMC Women's Health | Issue 1/2002

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Abstract

Background

This study was designed to evaluate the effects of a 24-month period of moderate exercise on serum lipids in menopausal women.

Methods

The subjects (40–60 y) were randomly divided into an exercise group (n = 14) and a control group (n = 13). The women in the exercise group were asked to participate in a 90-minute physical education class once a week and to record their daily steps as measured by a pedometer for 24 months.

Results

Mean of daily steps was significantly higher in the exercise group from about 6,800 to over 8,500 steps (P < 0.01). In the control group, the number of daily steps ranged from 5,700 to 6,800 steps throughout the follow-up period. A significant interaction between the exercise group and the control group in the changes og total cholesterol (TC), high-density lipoprotein cholesterol (HDLC) and TC : HDLC ratio could be observed (P < 0.05). By multiple regression analysis, the number of daily steps was related to HDLC and TC : HDLC levels after 24 months, and the changes in TC and HDLC concentrations.

Conclusions

These results suggest that daily exercise as well as increasing the number of daily steps can improve the profile of serum lipids.
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Literature
1.
Blum A, Cannon RO: Effects of oestrogens and selective oestrogen receptor modulators on serum lipoproteins and vascular function. Curr Opin Lipidol. 1998, 9: 575-586. 10.1097/00041433-199812000-00010.CrossRefPubMed
2.
Kardos A, Casadei B: Hormone replacement therapy and ischaemic heart disease among postmenopausal women. J Cardiovasc Risk. 1999, 6: 105-112.CrossRefPubMed
3.
Shimamoto T, Komachi Y, Inada H, Doi M, Sato S, Kitamura A, Iida M, Konishi N: Trends for coronary heart disease and stroke and their risk factors in Japan. Circulation. 1989, 79: 503-515.CrossRefPubMed
4.
Boyden TW, Pamenter RW, Going SB, Lohman TG, Hall MC, Houtkooper LB, Bunt JC, Ritenbaugh C, Aickin M: Resistance exercise training is associated with decreases in serum low-density lipoprotein cholesterol levels in premenopausal women. Arch Intern Med. 1993, 153: 97-100. 10.1001/archinte.153.1.97.CrossRefPubMed
5.
Lindheim SR, Notelovitz M, Feldman E, Larsen S, Khan FY, Lobo RA: The independent effects of exercise and estrogen on lipids and lipoproteins in postmenopausal women. Obstet Gynecol. 1994, 83: 167-172.PubMed
6.
Motoyama M, Sunami Y, Kinoshita F, Irie T, Sasaki J, Arakawa K, Kiyonaga A, Tanaka H, Shindo M: The effects of long-term low intensity aerobic training and detraining on serum lipid and lipoprotein concentrations in elderly men and women. Eur J Appl occup Physiol. 1995, 70: 126-131.CrossRef
7.
Grandjean PW, Oden G, Crouse SF, Brown JA, Green JS: Lipid and lipoprotein changes in women following 6 months of exercise training in a worksite fitness program. J Sports Med Phys Fitness. 1996, 36: 54-59.PubMed
8.
Schuit AJ, Schouten EG, Miles TP, Evans WJ, Saris WHM, Kok FJ: The effect of six months training on weight, body fatness and serum lipids in apparently health elderly Dutch men and women. Int J Obes Relat Metab Disord. 1998, 22: 847-853. 10.1038/sj.ijo.0800671.CrossRefPubMed
9.
Brownell KD, Bachorik PS, Ayerle RS: Changes in plasma lipid and lipoprotein levels in men and women after a program of moderate exercise. Circulation. 1991, 65: 477-484.CrossRef
10.
Ponjee GAE, Janssen EME, Hermans J, van Wersch JWJ: Effects of long-term exercise of moderate intensity on anthropometric values and serum lipids and lipoproteins. Eur J clin Chem clin Biochem. 1995, 33: 121-126.PubMed
11.
Nieman DC, Warren BJ, O'Donnell KA, Dotson RG, Butterworth DE, Henson DA: Physical activity and serum lipids and lipoproteins in elderly women. J Am Geriatr Soc. 1993, 41: 1339-1344.CrossRefPubMed
12.
Sandvik L, Erikssen J, Thaulow E, Erikssen G, Mundal R, Rodahl K: Physical fitness as a predictor of mortality among health, middle-age Norwegian men. N Engl J Med. 1993, 328: 533-537. 10.1056/NEJM199302253280803.CrossRefPubMed
13.
Andersen LB: Physical activity and physical fitness as protection against premature disease or death. Scand J Med Sci Sports. 1995, 5: 318-328.CrossRefPubMed
14.
Am Coll Sports Med: Guidelines for exercise testing and prescription. Philadelphia PA, Lea and Feliger,. 1995, 5: 161-173.
15.
Pate RR: Physical activity and public health: A recommendation from the Centers for Disease Control and prevention and the American College of Sports Medicine. JAMA. 1995, 273: 402-407. 10.1001/jama.273.5.402.CrossRefPubMed
16.
Paffenbarger RS, Hyde RT, Wing AL, Hsieh CC: Physical activity, all-cause mortality, and longevity of college alumni. N Engl J Med. 1986, 314: 605-613.CrossRefPubMed
17.
Leon AS, Connett J, Jacobs DR, Rauramaa R: Leisure-time physical activity levels and risk of coronary heart disease and death: The multiple risk factor intervention trial. JAMA. 1987, 258: 2388-2395. 10.1001/jama.258.17.2388.CrossRefPubMed
18.
Karvonen MJ, Kentala E, Mustala O: The effects of training on heart rate. A longitudinal study. Ann Med Exper Biol Fenn. 1957, 35: 307-315.
19.
Ohkawa H, Ohishi N, Yagi K: Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem. 1979, 95: 351-358.CrossRefPubMed
20.
Stevenson JC, Grook D, Goldsland IF: Influence of age and menopause on serum lipids and lipoproteins in healthy women. Atherosclerosis. 1993, 98: 83-90.CrossRefPubMed
21.
Mabuchi H: Current state of and recent trends in serum lipid levels in the general Japanese population. J Arterioscler Thromb. 1996, 2: 122-132.CrossRef
22.
Fukami K, Koike K, Hirota K, Yoshikawa H, Miyake A: Perimenopausal changes in serum lipids and lipoproteins: a 7-year longitudinal study. Maturitas. 1995, 22: 193-197. 10.1016/0378-5122(95)00927-D.CrossRefPubMed
23.
Jensen J, Nilas L, Christiansen C: Influence of menopause on serum lipids and lipoproteins. Maturitas. 1990, 2: 321-331.CrossRef
24.
Blumenthal JA, Matthews K, Fredrikson M, Rifai N, Schniebolk S, German D, Steege J, Rodin J: Effects of exercise training on cardiovascular function and plasma lipid, lipoprotein, and apolipoprotein concentrations in premenopausal and postmenopausal women. Arterioscler Thromb. 1991, 11: 912-917.CrossRefPubMed
25.
Grandjean PW, Crouse SF, O'Brien BC, Rohack JJ, Brown JA: The effects of menopausal status and exercise training on serum lipids and the activities of intravascular enzymes related to lipid transport. Metabolism. 1998, 47: 377-383.CrossRefPubMed
26.
Wu Z, Wu X, Zhang Y: Relationship of menopausal status and sex hormones to serum lipids and blood pressure. Int J Epidemiol. 1990, 19: 297-302.CrossRefPubMed
27.
van Beresteijn EC, Korevaar JC, Huijbregts PCW, Schouten EG, Burema J, Kok FJ: Perimenopausal increase in serum cholesterol: a 10-year longitudinal study. Am J Epidemiol. 1993, 137: 383-392.PubMed
28.
Thomas TR, Adeniran SB, Iltis PW, Aquiar CA, Albers JJ: Effects of interval and continuous running on HDL-cholesterol, apoproteins A-1 and B, and LCAT. Can J Appl Sport Sci. 1985, 10: 52-59.PubMed
29.
Hardman AE, Hudson A: Brisk walking and serum lipid and lipoprotein variables in previous sedentary women: effects of 12 weeks of regular brisk walking followed by 12 weeks of detraining. Br J Sports Med. 1994, 28: 261-266.CrossRefPubMedPubMedCentral
30.
Lokey EA, Tran ZV: Effects of exercise training on serum lipid and lipoprotein concentrations in women: A meta-analysis. Int J Sports Med. 1989, 10: 424-429.CrossRefPubMed
31.
Hill JO, Thiel J, Heller PA, Markon C, Fletcher G, DiGirolamo M: Differences in effects of aerobic exercise training on blood lipids in men and women. Am J Cardiol. 1989, 63: 254-256. 10.1016/0002-9149(89)90297-X.CrossRefPubMed
32.
Santiago MC, Leon AS, Serfass RC: Failure of 40 weeks of brisk walking to alter blood lipids in normolipemic women. Can J Appl Physiol. 1995, 20: 417-428.CrossRefPubMed
33.
Irie M, Nagata S, Ikeda M, Miyata M: Effects of walking during all weekdays, holidays, and at work on mental and physical health in workers. Sangyo Eiseigaku zasshi. 1998, 40: 7-14.PubMed
34.
Hatano Y: The walking for the health. J Cli Sports Med. 1992, 9: 129-135.
35.
Duncan JJ, Gordon NF, Scott CB: Women walking for health and fitness. JAMA. 1991, 266: 3295-3299. 10.1001/jama.266.23.3295.CrossRefPubMed
36.
Reaven PD, McPhillips JB, Barrett-Connor EL, Criqui MH: Leisure time exercise and lipid and lipoprotein levels in an older population. J Am Geriatr Soc. 1990, 38: 847-854.CrossRefPubMed
37.
Blair SN, Kohl HW, Gordon NF: How much physical activity in good for health?. Annu Rev Public Health. 1992, 13: 99-126. 10.1146/annurev.publhealth.13.1.99.CrossRefPubMed
38.
Grandjean PW, Crouse SF, O'Brien BC, Rohack JJ: Influence of cholesterol status on blood lipid and lipoprotein enzyme responses to aerobic exercise. J Appl Physiol. 2000, 89: 472-480.PubMed
39.
Lehmann R, Engler H, Honegger R, Riesen W, Spinas GA: Alterations of lipolytic enzymes and high-density lipoprotein subfractions induced by physical activity in type 2 diabetes mellitus. Eur J Clin Invest. 2001, 31: 37-44. 10.1046/j.1365-2362.2001.00752.x.CrossRefPubMed
40.
Vasankari TJ, Kujala UM, Vasankari TM, Ahotupa M: Reduced oxidized LDL levels after a 10-month exercise program. Med Sci Sports Exerc. 1998, 30: 1496-1501. 10.1097/00005768-199810000-00005.CrossRefPubMed
41.
Marzatico F, Pansarasa O, Bertorelli L, Somenzini L, Della VG: Blood free radical antioxidant enzymes and lipid peroxides following long-distance and lactacidemic performances in highly trained aerobic and sprint athletes. J Sports Med Phys Fitness. 1997, 37: 235-239.PubMed
42.
Reddy KV, Kumar TC, Prasad M, Reddanna P: Pulmonary lipid peroxidation and antioxidant defenses during exhaustive physical exercise: the role of vitamin E and selenium. Nutrition. 1998, 14: 448-451. 10.1016/S0899-9007(98)00016-1.CrossRefPubMed
43.
Oldridge NB: A handbook of health enhancement and disease prevention. New York John Wiley. Edited by: Matarazzo MD, Weiss SM, Herd JA, Miller NE. 1984, 467-487.
Metadata
Title
Effects of long-term moderate exercise and increase in number of daily steps on serum lipids in women: randomised controlled trial [ISRCTN21921919]
Authors
Hiroko Sugiura
Haruo Sugiura
Kazue Kajima
Seyed Mohammad Mirbod
Hirotoshi Iwata
Toshio Matsuoka
Publication date
01-12-2002
Publisher
BioMed Central
Published in
BMC Women's Health / Issue 1/2002
Electronic ISSN: 1472-6874
DOI
https://doi.org/10.1186/1472-6874-2-3

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