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Published in: BMC Oral Health 1/2011

Open Access 01-12-2011 | Technical advance

A new portable monitor for measuring odorous compounds in oral, exhaled and nasal air

Authors: Naofumi Tamaki, Kenta Kasuyama, Mitsue Esaki, Takara Toshikawa, Shun-Ichi Honda, Daisuke Ekuni, Takaaki Tomofuji, Manabu Morita

Published in: BMC Oral Health | Issue 1/2011

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Abstract

Background

The B/B Checker®, a new portable device for detecting odorous compounds in oral, exhaled, and nasal air, is now available. As a single unit, this device is capable of detecting several kinds of gases mixed with volatile sulfur compounds (VSC) in addition to other odorous gasses. The purpose of the present study was to evaluate the effectiveness of the B/B Checker® for detecting the malodor level of oral, exhaled, and nasal air.

Methods

A total of 30 healthy, non-smoking volunteers (16 males and 14 females) participated in this study. The malodor levels in oral, exhaled, and nasal air were measured using the B/B Checker® and by organoleptic test (OT) scores. The VSCs in each air were also measured by gas chromatography (GC). Associations among B/B Checker® measurements, OT scores and VSC levels were analyzed using Spearman correlation coefficients. In order to determine the appropriate B/B Checker® level for screening subjects with malodor, sensitivity and specificity were calculated using OT scores as an identifier for diagnosing oral malodor.

Results

In oral and nasal air, the total VSC levels measured by GC significantly correlated to that measured by the B/B Checker®. Significant correlation was observed between the results of OT scores and the B/B Checker® measurements in oral (r = 0.892, p < 0.001), exhaled (r = 0.748, p < 0.001) and nasal air (r = 0.534, p < 0.001). The correlation between the OT scores and VSC levels was significant only for oral air (r = 0.790, p < 0.001) and nasal air (r = 0.431, p = 0.002); not for exhaled air (r = 0.310, p = 0.096). When the screening level of the B/B Checker® was set to 50.0 for oral air, the sensitivity and specificity were 1.00 and 0.90, respectively. On the other hand, the screening level of the B/B Checker® was set to 60.0 for exhaled air, the sensitivity and specificity were 0.82 and 1.00, respectively.

Conclusion

The B/B Checker® is useful for objective evaluation of malodor in oral, exhaled and nasal air and for screening subjects with halitosis.

Trial registration

ClinicalTrials.gov: NCT01139073
Appendix
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Literature
2.
go back to reference Tessier JF, Kulkarni GV: Bad breath: etiology, diagnosis and treatment. Oral Health. 1991, 81: 19-22.PubMed Tessier JF, Kulkarni GV: Bad breath: etiology, diagnosis and treatment. Oral Health. 1991, 81: 19-22.PubMed
3.
go back to reference Bosy A: Oral malodor: philosophical and practical aspects. J Can Dent Assoc. 1997, 63: 196-201.PubMed Bosy A: Oral malodor: philosophical and practical aspects. J Can Dent Assoc. 1997, 63: 196-201.PubMed
4.
go back to reference Miyazaki H, Sakao S, Katoh Y, Takehara T: Oral malodor in the general population of Japan. Bad breath: research perspectives. 1995, Tel Aviv: Ramot Publishing, 119-136. Miyazaki H, Sakao S, Katoh Y, Takehara T: Oral malodor in the general population of Japan. Bad breath: research perspectives. 1995, Tel Aviv: Ramot Publishing, 119-136.
5.
go back to reference Tonzetich J, Richter VJ: Evaluation of volatile odoriferous components of saliva. Arch Oral Biol. 1964, 9: 39-45. 10.1016/0003-9969(64)90042-1.CrossRefPubMed Tonzetich J, Richter VJ: Evaluation of volatile odoriferous components of saliva. Arch Oral Biol. 1964, 9: 39-45. 10.1016/0003-9969(64)90042-1.CrossRefPubMed
6.
go back to reference Tonzetich J: Direct gas chromatographic analysis of sulphur compounds in mouth air in man. Arch Oral Biol. 1971, 16: 587-597. 10.1016/0003-9969(71)90062-8.CrossRefPubMed Tonzetich J: Direct gas chromatographic analysis of sulphur compounds in mouth air in man. Arch Oral Biol. 1971, 16: 587-597. 10.1016/0003-9969(71)90062-8.CrossRefPubMed
7.
go back to reference Rosenberg M: Clinical assessment of bad breath: current concepts. J Am Dent Assoc. 1996, 127: 475-482.CrossRefPubMed Rosenberg M: Clinical assessment of bad breath: current concepts. J Am Dent Assoc. 1996, 127: 475-482.CrossRefPubMed
8.
go back to reference Monteiro-Amado F, Montenegro Chinellato LE, Tárzia O, Rubo de Rezende ML: Evaluation of oral and nasal odor in patients with and without cleft lip and palate: preliminary report. Cleft Palate Craniofac J. 2004, 41: 661-663. 10.1597/02-163.1.CrossRefPubMed Monteiro-Amado F, Montenegro Chinellato LE, Tárzia O, Rubo de Rezende ML: Evaluation of oral and nasal odor in patients with and without cleft lip and palate: preliminary report. Cleft Palate Craniofac J. 2004, 41: 661-663. 10.1597/02-163.1.CrossRefPubMed
10.
go back to reference Tonzetich J, Coil JM, Ng W: Gas chromatographic method for trapping and detection of volatile organic compounds from human mouth air. J Clin Dent. 1991, 2: 79-82.PubMed Tonzetich J, Coil JM, Ng W: Gas chromatographic method for trapping and detection of volatile organic compounds from human mouth air. J Clin Dent. 1991, 2: 79-82.PubMed
11.
go back to reference Rosenberg M, Kulkarni GV, Bosy A, McCulloch CAG: Reproducibility and sensitivity of oral malodor measurements with a portable sulfide monitor. J Dent Res. 1991, 70: 1436-1440. 10.1177/00220345910700110801.CrossRefPubMed Rosenberg M, Kulkarni GV, Bosy A, McCulloch CAG: Reproducibility and sensitivity of oral malodor measurements with a portable sulfide monitor. J Dent Res. 1991, 70: 1436-1440. 10.1177/00220345910700110801.CrossRefPubMed
12.
go back to reference Ueno M, Shinada K, Yanagisawa T, Mori C, Yokoyama S, Furukawa S, Takehara S, Kawaguchi Y: Clinical oral malodor measurement with a portable sulfide monitor. Oral Dis. 2008, 14: 264-269. 10.1111/j.1601-0825.2007.01374.x.CrossRefPubMed Ueno M, Shinada K, Yanagisawa T, Mori C, Yokoyama S, Furukawa S, Takehara S, Kawaguchi Y: Clinical oral malodor measurement with a portable sulfide monitor. Oral Dis. 2008, 14: 264-269. 10.1111/j.1601-0825.2007.01374.x.CrossRefPubMed
13.
go back to reference Murata T, Rahardjo A, Fujiyama Y, Yamaga T, Hanada M, Yaegaki K, Miyazaki H: Development of a compact and simple gas chromatography for oral malodor measurement. J Periodontol. 2006, 77: 1142-1147. 10.1902/jop.2006.050388.CrossRefPubMed Murata T, Rahardjo A, Fujiyama Y, Yamaga T, Hanada M, Yaegaki K, Miyazaki H: Development of a compact and simple gas chromatography for oral malodor measurement. J Periodontol. 2006, 77: 1142-1147. 10.1902/jop.2006.050388.CrossRefPubMed
14.
go back to reference Kostelc JG, Preti G, Zelson PR, Brauner L, Baehni P: Oral odors in early experimental gingivitis. J Periodont Res. 1984, 19: 303-312. 10.1111/j.1600-0765.1984.tb00821.x.CrossRefPubMed Kostelc JG, Preti G, Zelson PR, Brauner L, Baehni P: Oral odors in early experimental gingivitis. J Periodont Res. 1984, 19: 303-312. 10.1111/j.1600-0765.1984.tb00821.x.CrossRefPubMed
15.
go back to reference Goldberg S, Kozlovsky A, Gordon D, Gelernter I, Sintov A, Rosenberg M: Cadaverine as a putative component of oral malodor. J Dent Res. 1994, 73: 1168-1172.PubMed Goldberg S, Kozlovsky A, Gordon D, Gelernter I, Sintov A, Rosenberg M: Cadaverine as a putative component of oral malodor. J Dent Res. 1994, 73: 1168-1172.PubMed
16.
go back to reference Rosenberg M, McCulloch CA: Measurement of oral malodor: current methods and future prospects. J Periodontol. 1992, 63: 776-782.CrossRefPubMed Rosenberg M, McCulloch CA: Measurement of oral malodor: current methods and future prospects. J Periodontol. 1992, 63: 776-782.CrossRefPubMed
17.
go back to reference Doruk C, Oztürk F, Ozdemir H, Nalçaci R: Oral and nasal malodor in patients with and without cleft lip and palate who had undergone orthodontic therapy. Cleft Palate Craniofac J. 2008, 45: 481-484. 10.1597/07-074.1.CrossRefPubMed Doruk C, Oztürk F, Ozdemir H, Nalçaci R: Oral and nasal malodor in patients with and without cleft lip and palate who had undergone orthodontic therapy. Cleft Palate Craniofac J. 2008, 45: 481-484. 10.1597/07-074.1.CrossRefPubMed
18.
go back to reference Shinada K, Ueno M, Konishi C, Takehara S, Yokoyama S, Kawaguchi Y: A randomized double blind crossover placebo-controlled clinical trial to assess the effects of a mouthwash containing chlorine dioxide on oral malodor. Trials. 2008, 9: 71-10.1186/1745-6215-9-71.CrossRefPubMedPubMedCentral Shinada K, Ueno M, Konishi C, Takehara S, Yokoyama S, Kawaguchi Y: A randomized double blind crossover placebo-controlled clinical trial to assess the effects of a mouthwash containing chlorine dioxide on oral malodor. Trials. 2008, 9: 71-10.1186/1745-6215-9-71.CrossRefPubMedPubMedCentral
19.
go back to reference Shinada K, Ueno M, Konishi C, Takehara S, Yokoyama S, Zaitsu T, Ohnuki M, Wright F, Kawaguchi Y: Effects of a mouthwash with chlorine dioxide on oral malodor and salivary bacteria: a randomized placebo-controlled 7-day trial. Trials. 2010, 11: 14-10.1186/1745-6215-11-14.CrossRefPubMedPubMedCentral Shinada K, Ueno M, Konishi C, Takehara S, Yokoyama S, Zaitsu T, Ohnuki M, Wright F, Kawaguchi Y: Effects of a mouthwash with chlorine dioxide on oral malodor and salivary bacteria: a randomized placebo-controlled 7-day trial. Trials. 2010, 11: 14-10.1186/1745-6215-11-14.CrossRefPubMedPubMedCentral
20.
go back to reference Morita M, Wang HL: Relationship between sulcular sulfide level and oral malodor in subjects with periodontal disease. J Periodontol. 2001, 72: 79-84. 10.1902/jop.2001.72.1.79.CrossRefPubMed Morita M, Wang HL: Relationship between sulcular sulfide level and oral malodor in subjects with periodontal disease. J Periodontol. 2001, 72: 79-84. 10.1902/jop.2001.72.1.79.CrossRefPubMed
21.
go back to reference Van den Velde S, van Steenberghe D, Van hee P, Quirynen M: Detection of Odorous Compounds in Breath. J Dent Res. 2009, 88: 285-289.CrossRefPubMed Van den Velde S, van Steenberghe D, Van hee P, Quirynen M: Detection of Odorous Compounds in Breath. J Dent Res. 2009, 88: 285-289.CrossRefPubMed
22.
go back to reference Tangeman A, Winkel EG: Intra- and extra-oral halitosis: finding of a new form of extra-oral blood-borne halitosis caused by dimethyl sulfide. J Clin Periodontol. 2007, 34: 748-755. 10.1111/j.1600-051X.2007.01116.x.CrossRef Tangeman A, Winkel EG: Intra- and extra-oral halitosis: finding of a new form of extra-oral blood-borne halitosis caused by dimethyl sulfide. J Clin Periodontol. 2007, 34: 748-755. 10.1111/j.1600-051X.2007.01116.x.CrossRef
23.
go back to reference Monteiro-Amado F, Chinellato LE, de Rezende ML: Evaluation of oral and nasal halitosis parameters in patients with repaired cleft lip and/or palate. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005, 100: 682-687. 10.1016/j.tripleo.2005.03.019.CrossRefPubMed Monteiro-Amado F, Chinellato LE, de Rezende ML: Evaluation of oral and nasal halitosis parameters in patients with repaired cleft lip and/or palate. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005, 100: 682-687. 10.1016/j.tripleo.2005.03.019.CrossRefPubMed
24.
go back to reference Monteiro-Amado F, Montenegro Chinellato LE, Tárzia O, de Rezende ML: Evaluation of oral and nasal odor in patients with and without cleft lip and palate: preliminary report. Cleft Palate Craniofac J. 2004, 41: 661-663. 10.1597/02-163.1.CrossRefPubMed Monteiro-Amado F, Montenegro Chinellato LE, Tárzia O, de Rezende ML: Evaluation of oral and nasal odor in patients with and without cleft lip and palate: preliminary report. Cleft Palate Craniofac J. 2004, 41: 661-663. 10.1597/02-163.1.CrossRefPubMed
25.
go back to reference Scully C, Greenman J: Halitosis (breath odor). Periodontology 2000. 2008, 48: 66-75. 10.1111/j.1600-0757.2008.00266.x.CrossRefPubMed Scully C, Greenman J: Halitosis (breath odor). Periodontology 2000. 2008, 48: 66-75. 10.1111/j.1600-0757.2008.00266.x.CrossRefPubMed
26.
go back to reference Studer SM, Orens JB, Krishnan JA, Cope KA, Yang S, Conte JV, Becker PB, Risby TH: Patterns and significance of exhaled-breath biomarkers in lung transplant recipients with acute allograft rejection. J Heart Lung Transplant. 2001, 20: 1158-1166. 10.1016/S1053-2498(01)00343-6.CrossRefPubMed Studer SM, Orens JB, Krishnan JA, Cope KA, Yang S, Conte JV, Becker PB, Risby TH: Patterns and significance of exhaled-breath biomarkers in lung transplant recipients with acute allograft rejection. J Heart Lung Transplant. 2001, 20: 1158-1166. 10.1016/S1053-2498(01)00343-6.CrossRefPubMed
Metadata
Title
A new portable monitor for measuring odorous compounds in oral, exhaled and nasal air
Authors
Naofumi Tamaki
Kenta Kasuyama
Mitsue Esaki
Takara Toshikawa
Shun-Ichi Honda
Daisuke Ekuni
Takaaki Tomofuji
Manabu Morita
Publication date
01-12-2011
Publisher
BioMed Central
Published in
BMC Oral Health / Issue 1/2011
Electronic ISSN: 1472-6831
DOI
https://doi.org/10.1186/1472-6831-11-15

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