Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
BMC Urology
Published in: BMC Urology 1/2013

Open Access 01-12-2013 | Case report

Successful minimally-invasive management of a case of giant prostatic hypertrophy associated with recurrent nephrogenic adenoma of the prostate

Authors: Robert M Learney, Sachin Malde, Mark Downes, Nitin Shrotri

Published in: BMC Urology | Issue 1/2013

Login to get access

Abstract

Background

Benign Prostatic Hypertrophy (BPH) is said to affect at least a third of men over 60. However, the literature contains fewer than 200 reports of prostates over 200g in mass - Giant Prostatic Hypertrophy (GPH). Nephrogenic adenomas are benign lesions of the urinary tract that are believed to represent the local proliferation of shed renal tubular cells implanting at sites of urothelial injury.

Case presentation

We present the first case in the literature of these two rare pathologies co-existing in the same patient and the successful management and 36-month follow-up of the patient’s symptoms with minimally invasive therapy, including the still-uncommon selective prostatic artery embolisation. We also briefly discuss the role of PAX2 in injured renal tissues and nephrogenic adenomas.

Conclusions

Symptomatic Giant Prostatic Hypertrophy (GPH) can be successfully managed with a combination of serial TURPs, 5 α-reductase inhibition and selective prostatic artery embolisation (SPAE).
Appendix
Available only for authorised users
Literature
1.
2.
Huang K, Ly He: Giant prostatic hyperplasia: a case report and review of the literature. Zhonghua Nan Ke Xue. 2011, 17 (2): 151-155.PubMed
3.
Yonou H, Goya M, Miyazato M, Sugaya K, Hatano T, Ogawa Y: Giant prostatic hypertrophy: a case report. Hinyokika Kiyo. 1999, 45 (5): 375-377.PubMed
4.
Noguchi M, Yahara J, Motomori T, Noda S: Transurethral electrovaporization for giant prostatic hyperplasia: report of a case. Kurume Med J. 2003, 50 (3–4): 151-153.CrossRefPubMed
5.
Davis TA: Hamartoma of the urinary bladder. Northwest Med. 1949, 48 (3): 182-185.PubMed
6.
Kunju LP: Nephrogenic adenoma: report of a case and review of morphologic mimics. Arch Pathol Lab Med. 2010, 134 (10): 1455-1459.PubMed
7.
Fromont G, Barcat L, Gaudin J, Irani J: Revisiting the immunophenotype of nephrogenic adenoma. Am J Surg Pathol. 2009, 33 (11): 1654-1658. 10.1097/PAS.0b013e3181b40061.CrossRefPubMed
8.
Rahemtullah A, Oliva E: Nephrogenic adenoma: an update on an innocuous but troublesome entity. Adv Anat Pathol. 2006, 13 (5): 247-255. 10.1097/01.pap.0000213047.69564.c2.CrossRefPubMed
9.
Mazal PR, Schaufler R, Altenhuber-Muller R, Haitel A, Watschinger B, Kratzik C, Krupitza G, Regele H, Meisl FT, Zechner O, Kerjaschki D, Susani M: Derivation of nephrogenic adenomas from renal tubular cells in kidney-transplant recipients. N Engl J Med. 2002, 347 (9): 653-659. 10.1056/NEJMoa013413.CrossRefPubMed
10.
Tong GX, Melamed J, Mansukhani M, Memeo L, Hernandez O, Deng FM, Chiriboga L, Waisman J: PAX2: a reliable marker for nephrogenic adenoma. Mod Pathol. 2006, 19 (3): 356-363. 10.1038/modpathol.3800535.CrossRefPubMed
11.
Allan CH, Epstein JI: Nephrogenic adenoma of the prostatic urethra: a mimicker of prostate adenocarcinoma. Am J Surg Pathol. 2001, 25 (6): 802-808. 10.1097/00000478-200106000-00013.CrossRefPubMed
12.
Malpica A, Ro JY, Troncoso P, Ordonez NG, Amin MB, Ayala AG: Nephrogenic adenoma of the prostatic urethra involving the prostate gland: a clinicopathologic and immunohistochemical study of eight cases. Hum Pathol. 1994, 25 (4): 390-395. 10.1016/0046-8177(94)90148-1.CrossRefPubMed
13.
Lindoso RS, Verdoorn KS, Einicker-Lamas M: Renal recovery after injury: the role of Pax-2. Nephrol Dial Transplant. 2009, 24 (9): 2628-2633. 10.1093/ndt/gfp307.CrossRefPubMed
14.
Discenza MT, He S, Lee TH, Chu LL, Bolon B, Goodyer P, Eccles M, Pelletier J: WT1 is a modifier of the Pax2 mutant phenotype: cooperation and interaction between WT1 and Pax2. Oncogene. 2003, 22 (50): 8145-8155. 10.1038/sj.onc.1206997.CrossRefPubMed
15.
Levin ME, Schlussel RN: Molecular genetics of renal development. Curr Urol Rep. 2003, 4 (2): 171-176. 10.1007/s11934-003-0046-7.CrossRefPubMed
16.
Choong SK, Walkden M, Kirby R: The management of intractable haematuria. BJU Int. 2000, 86 (9): 951-959.CrossRefPubMed
17.
Liguori G, Amodeo A, Mucelli FP, Patel H, Marco D, Belgrano E, Trombetta C: Intractable haematuria: long-term results after selective embolization of the internal iliac arteries. BJU Int. 2010, 106 (4): 500-503. 10.1111/j.1464-410X.2009.09192.x.CrossRefPubMed
18.
Rastinehad AR, Caplin DM, Ost MC, VanderBrink BA, Lobko I, Badlani GH, Weiss GH, Kavoussi LR, Siegel DN: Selective arterial prostatic embolization (SAPE) for refractory hematuria of prostatic origin. Urology. 2008, 71 (2): 181-184. 10.1016/j.urology.2007.09.012.CrossRefPubMed
19.
Pisco JM, Pinheiro LC, Bilhim T, Duarte M, Mendes JR, Oliveira AG: Prostatic arterial embolization to treat benign prostatic hyperplasia. J Vasc Interv Radiol. 2011, 22: 11-19. 10.1016/j.jvir.2010.09.030.CrossRefPubMed
Metadata
Title
Successful minimally-invasive management of a case of giant prostatic hypertrophy associated with recurrent nephrogenic adenoma of the prostate
Authors
Robert M Learney
Sachin Malde
Mark Downes
Nitin Shrotri
Publication date
01-12-2013
Publisher
BioMed Central
Published in
BMC Urology / Issue 1/2013
Electronic ISSN: 1471-2490
DOI
https://doi.org/10.1186/1471-2490-13-18

Other articles of this Issue 1/2013

BMC Urology 1/2013 Go to the issue

Research article

Use of daptomycin in the treatment of vancomycin-resistant enterococcal urinary tract infections: a short case series

Case report

Chronic expanding hematoma in the retroperitoneal space: a case report

Research article

Morphometric profile of the localised renal tumors managed either by open or robot-assisted nephron-sparing surgery: the impact of scoring systems on the decision making process

Research article

Health economics perspective of fesoterodine, tolterodine or solifenacin as first-time therapy for overactive bladder syndrome in the primary care setting in Spain

Case report

Severe hematuria after transurethral electrocoagulation in a patient with an arteriovesical fistula

Commentary

Commentary on: “Focal cryosurgical ablation of the prostate: A single institute’s perspective”