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Open Access 01-12-2010 | Case report

Association between gefitinib and hemorrhagic cystitis and severely contracted bladder: a case report

Authors: Maki Arakawa, Kogenta Nakamura, Yoshiaki Yamada, Charles J Rosser, Motoi Tobiume, Hiroko Saito, Takaaki Hasegawa, Nobuaki Honda

Published in: BMC Urology | Issue 1/2010

Abstract

Background

Gefitinib remains an excellent treatment option for patients with a variety of cancers, including non small cell lung cancer (NSCLC). However, clinicians must be aware of the potential of gefitinib to cause an inflammatory reaction in the skin, lungs and bladder.

Case Presentation

We present a case on hemorrhagic cystitis and severaly contracted bladder in a patient with NSCLC on gefitinib.

Conclusions

Further studies are needed to substantiate the association of gefitinib therapy with hemorrhagic cystitis and contracted bladder.

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Kim ES, Hirsh V, Mok T, Socinski MA, Gervais R, Wu YL, Li LY, Watkins CL, Sellers MV, Lowe ES, Sun Y, Liao ML, Osterlind K, Reck M, Armour AA, Shepherd FA, Lippman SM, Douillard JY: Gefitinib versus docetaxel in previously treated non-small-cell lung cancer (INTEREST): a randomised phase III trial. Lancet. 2008, 372 (9652): 1809-1818. 10.1016/S0140-6736(08)61758-4.CrossRefPubMed

Maruyama R, Nishiwaki Y, Tamura T, Yamamoto N, Tsuboi M, Nakagawa K, Shinkai T, Negoro S, Imamura F, Eguchi K, Takeda K, Inoue A, Tomii K, Harada M, Masuda N, Jiang H, Itoh Y, Ichinose Y, Saijo N, Fukuoka M: Phase III study, V-15-32, of gefitinib versus docetaxel in previously treated Japanese patients with non-small-cell lung cancer. J Clin Oncol. 2008, 26 (26): 4244-52. 10.1200/JCO.2007.15.0185.CrossRefPubMed

Argiris A, Mittal N: Gefitinib as first-line, compassionate use therapy in patients with advanced non-small-cell lung cancer. Lung Cancer. 2004, 43 (3): 317-322. 10.1016/j.lungcan.2003.10.010.CrossRefPubMed

The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2490/10/6/prepub

Title: Association between gefitinib and hemorrhagic cystitis and severely contracted bladder: a case report
Authors: Maki Arakawa
Kogenta Nakamura
Yoshiaki Yamada
Charles J Rosser
Motoi Tobiume
Hiroko Saito
Takaaki Hasegawa
Nobuaki Honda
Publication date: 01-12-2010
Publisher: BioMed Central
Published in: BMC Urology / Issue 1/2010
Electronic ISSN: 1471-2490
DOI: https://doi.org/10.1186/1471-2490-10-6

At a glance: The STEP trials

Springer Medicine

Association between gefitinib and hemorrhagic cystitis and severely contracted bladder: a case report

Abstract

Background

Case Presentation

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Case Presentation

Conclusions

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