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Open Access 01-12-2011 | Study protocol

C lamp-Cru shin g versus s tapler h epatectomy for transection of the parenchyma in elective hepatic resection (CRUNSH) - A randomized controlled trial (NCT01049607)

Authors: Nuh N Rahbari, Heike Elbers, Moritz Koch, Thomas Bruckner, Patrick Vogler, Fabian Striebel, Peter Schemmer, Arianeb Mehrabi, Markus W Büchler, Jürgen Weitz

Published in: BMC Surgery | Issue 1/2011

Abstract

Background

Hepatic resection is still associated with significant morbidity. Although the period of parenchymal transection presents a crucial step during the operation, uncertainty persists regarding the optimal technique of transection. It was the aim of the present randomized controlled trial to evaluate the efficacy and safety of hepatic resection using the technique of stapler hepatectomy compared to the simple clamp-crushing technique.

Methods/Design

The CRUNSH Trial is a prospective randomized controlled single-center trial with a two-group parallel design. Patients scheduled for elective hepatic resection without extrahepatic resection at the Department of General-, Visceral- and Transplantation Surgery, University of Heidelberg are enrolled into the trial and randomized intraoperatively to hepatic resection by the clamp-crushing technique and stapler hepatectomy, respectively. The primary endpoint is total intraoperative blood loss. A set of general and surgical variables are documented as secondary endpoints. Patients and outcome-assessors are blinded for the treatment intervention.

Discussion

The CRUNSH Trial is the first randomized controlled trial to evaluate efficacy and safety of stapler hepatectomy compared to the clamp-crushing technique for parenchymal transection during elective hepatic resection.

Trial Registration

ClinicalTrials.gov: NCT01049607

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The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2482/11/22/prepub

Title: C lamp-Cru shin g versus s tapler h epatectomy for transection of the parenchyma in elective hepatic resection (CRUNSH) - A randomized controlled trial (NCT01049607)
Authors: Nuh N Rahbari
Heike Elbers
Moritz Koch
Thomas Bruckner
Patrick Vogler
Fabian Striebel
Peter Schemmer
Arianeb Mehrabi
Markus W Büchler
Jürgen Weitz
Publication date: 01-12-2011
Publisher: BioMed Central
Published in: BMC Surgery / Issue 1/2011
Electronic ISSN: 1471-2482
DOI: https://doi.org/10.1186/1471-2482-11-22

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

C lamp-Cru shin g versus s tapler h epatectomy for transection of the parenchyma in elective hepatic resection (CRUNSH) - A randomized controlled trial (NCT01049607)

Abstract

Background

Methods/Design

Discussion

Trial Registration

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Methods/Design

Discussion

Trial Registration

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