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BMC Musculoskeletal Disorders
Published in: BMC Musculoskeletal Disorders 1/2004

Open Access 01-12-2004 | Debate

Roles of hyaluronan in bone resorption

Author: Charles W Prince

Published in: BMC Musculoskeletal Disorders | Issue 1/2004

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Abstract

Background

Hyaluronan, an unsulfated glycosaminoglycan, while being closely linked to osteoclast function several years ago, has received little attention lately. Given recent new knowledge of hyaluronan's possible cell binding abilities, it is important to re-examine the role of this polysaccharide in bone homeostasis.

Discussion

Previously published data demonstrating a linkage between induction of hyaluronan synthesis and osteoclast-mediated bone resorption are reviewed. Suggestions are made involving the cell binding ability of hyaluronan and its potential to mediate osteoclast binding to bone surfaces and its potential to serve as a diffusion barrier and participate in the sealing zone required for osteoclast-mediated bone resorption.

Summary

This brief article summarizes previous studies linking HA to bone resorption and suggests roles for hyaluronan in the process of bone resorption.
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Metadata
Title
Roles of hyaluronan in bone resorption
Author
Charles W Prince
Publication date
01-12-2004
Publisher
BioMed Central
Published in
BMC Musculoskeletal Disorders / Issue 1/2004
Electronic ISSN: 1471-2474
DOI
https://doi.org/10.1186/1471-2474-5-12

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