Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
BMC Musculoskeletal Disorders
Published in: BMC Musculoskeletal Disorders 1/2014

Open Access 01-12-2014 | Study protocol

A three month controlled intervention of intermittent whole body vibration designed to improve functional ability and attenuate bone loss in patients with rheumatoid arthritis

Authors: Alessandra Prioreschi, Mohammed Tikly, Joanne A McVeigh

Published in: BMC Musculoskeletal Disorders | Issue 1/2014

Login to get access

Abstract

Background

Rheumatoid arthritis (RA) is a chronic autoimmune condition that results in pain and disability. Patients with RA have a decreased functional ability and are forced into a sedentary lifestyle and as such, these patients often become predisposed to poor bone health. Patients with RA may also experience a decreased health related quality of life (HRQoL) due to their disease. Whole body vibration (WBV) is a form of exercise that stimulates bone loading through forced oscillation. WBV has also been shown to decrease pain and fatigue in other rheumatic diseases, as well as to increase muscle strength. This paper reports on the development of a semi randomised controlled clinical trial to assess the impact of a WBV intervention aiming to improve functional ability, attenuate bone loss, and improve habitual physical activity levels in patients with RA.

Methods/Design

This study is a semi randomised, controlled trial consisting of a cohort of patients with established RA assigned to either a WBV group or a CON (control) group. Patients in the WBV group will undergo three months of twice weekly intermittent WBV sessions, while the CON group will receive standard care and continue with normal daily activities. All patients will be assessed at baseline, following the three month intervention, and six months post intervention. Main outcomes will be an improvement in functional ability as assessed by the HAQ. Secondary outcomes are attenuation of loss of bone mineral density (BMD) at the hip and changes in RA disease activity, HRQoL, habitual physical activity levels and body composition.

Discussion

This study will provide important information regarding the effects of WBV on functional ability and BMD in patients with RA, as well as novel data regarding the potential changes in objective habitual physical activity patterns that may occur following the intervention. The sustainability of the intervention will also be assessed.

Trial registration

PACTR20140500082​3418 (19/05/2014).
Appendix
Available only for authorised users
Literature
1.
Sokolove J, Strand V: Rheumatoid arthritis classification criteria. Bull NYU Hosp Jt Dis. 2010, 68 (3): 232-238.PubMed
2.
Ngian G: Rheumatoid arthritis. Austr Family Phys. 2010, 39 (9): 626-628.
3.
Kalyoncu U, Dougados M, Daure J: Reporting of patient-reported outcomes in recent trials in rheumatoid arthritis: a systematic literature review. Ann Rheum Dis. 2009, 68: 183-190. 10.1136/ard.2007.084848.CrossRefPubMed
4.
Schneider M, Manabile E, Tikly M: Social aspects of living with rheumatoid arthritis: a qualitative descriptive study in Soweto, South Africa - a low resource context. Health Qual Life Outcomes. 2008, 6: 54-10.1186/1477-7525-6-54.CrossRefPubMedPubMedCentral
5.
Metsios GS, Stavropoulos-Kalinoglou A, Veldhuijzen van Zanten JJCS, Treharne GJ, Panoulas VF, Douglas KMJ, Koutedakis Y, Kitas GD: Rheumatoid arthritis, cardiovascular disease and physical exercise: a systematic review. Rheumatology (Oxford). 2008, 47 (3): 239-248.CrossRef
6.
Chantler I, Mitchell D, Fuller A: Actigraphy quantifies reduced voluntary physical activity in women with primary dysmenorrhea. J Pain Am Pain Soc. 2009, 10 (1): 38-46. 10.1016/j.jpain.2008.07.002.CrossRef
7.
Kayes NM, Schluter PJ, Mcpherson KM, Leete M, Mawston G, Taylor D: Exploring Actical accelerometers as an objective measure of physical activity in people with multiple sclerosis. Arch Phys Med Rehabil. 2009, 90 (4): 594-601. 10.1016/j.apmr.2008.10.012.CrossRefPubMed
8.
Pruitt LA, Glynn NW, King AC, Guralnik JM, Aiken EK, Miller G, Klaskeu WL: Use of accelerometry to measure physical activity in older adults at risk for mobility disability. J Aging Phys Act. 2008, 16 (4): 416-434.PubMedPubMedCentral
9.
Crouter SE, Dellavalle DM, Horton M, Haas JD, Frongillo EA, Bassett DR: Validity of the actical for estimating free-living physical activity. Eur J Appl Physiol. 2010, doi:10.1007/s00421-010-1758-2
10.
Farr JN, Going SB, Lohman TG, Rankin L, Kasle S, Cornett M, Cussler E: Physical activity levels in patients with early knee osteoarthritis measured by accelerometry. Rheumatology. 2008, 59 (9): 1229-1236.
11.
Semanik P, Song J, Chang RW, Manheim L, Ainsworth B, Dunlop D: Assessing physical activity in persons with rheumatoid arthritis using accelerometry. Med Sci Sports Exerc. 2010, 42 (8): 1493-1501. 10.1249/MSS.0b013e3181cfc9da.CrossRefPubMedPubMedCentral
12.
Prioreschi A, Hodkinson B, Avidon I, Tikly M, McVeigh JA: The clinical utility of accelerometry in patients with rheumatoid arthritis. Rheumatology (Oxford). 2013, 53: 1-7.
13.
Haugeberg G, Uhlig T, Falch JA, Halse JI, Kvien TK: Bone mineral density and frequency of osteoporosis in female patients with rheumatoid arthritis: results from 394 patients in the Oslo County Rheumatoid Arthritis register. Arthritis Rheum. 2000, 43 (3): 522-530. 10.1002/1529-0131(200003)43:3<522::AID-ANR7>3.0.CO;2-Y.CrossRefPubMed
14.
Gough AK, Lilley J, Eyre S, Holder RL, Emery P: Generalised bone loss in patients with early rheumatoid arthritis. Lancet. 1994, 344 (8914): 23-27. 10.1016/S0140-6736(94)91049-9.CrossRefPubMed
15.
Laan M: Bone mineral density in patients with recent onset rheumatoid arthritis: influence of disease activity. Ann Rheum Dis. 1993, 52: 21-26. 10.1136/ard.52.1.21.CrossRefPubMedPubMedCentral
16.
Deodhar AA, Woolf AD: Bone mass measurement and bone metabolism in rheumatoid arthritis: a review. Br J Rheumatol. 1996, 35 (4): 309-322. 10.1093/rheumatology/35.4.309.CrossRefPubMed
17.
Pearson OM, Lieberman DE: The aging of Wolff’s “law”: ontogeny and responses to mechanical loading in cortical bone. Am J Phys Anthropol. 2004, 39: 63-99.CrossRefPubMed
18.
Turner CH: Three rules for bone adaptation to mechanical stimuli. Bone. 1998, 23 (5): 399-407. 10.1016/S8756-3282(98)00118-5.CrossRefPubMed
19.
Geraci A, Maria S: Osteoporosis in Rheumatoid Arthritis. 2006, 75-93.
20.
Turner CH, Robling AG: Exercises for improving bone strength. Br J Sports Med. 2000, 39 (4): 188-189.CrossRef
21.
Plasqui G: The role of physical activity in rheumatoid arthritis. Physiol Behav. 2008, 94: 270-275. 10.1016/j.physbeh.2007.12.012.CrossRefPubMed
22.
Wysocki A, Butler M, Shamliyan T, Kane RL: Whole-body vibration therapy for osteoporosis: state of the science. Annals Int Med. 2011, 155 (10): 680-686. 10.7326/0003-4819-155-10-201111150-00006.CrossRef
23.
Totosy De Zepetnek JO, Giangregorio LM, Craven BC: Whole-body vibration as potential intervention for people with low bone mineral density and osteoporosis: a review. J Rehabil Res Dev. 2009, 46 (4): 529-10.1682/JRRD.2008.09.0136.CrossRefPubMed
24.
Rittweger J: Vibration as an exercise modality: how it may work, and what its potential might be. Eur J Appl Physiol. 2010, 108 (5): 877-904. 10.1007/s00421-009-1303-3.CrossRefPubMed
25.
Kawanabe K, Kawashima A, Sasimoto I, Takeda T, Sato Y, Iwamoto J: Effect of whole-body vibration exercise and muscle strengthening, balance, and walking exercises on walking ability in the elderly. Keio J Med. 2007, 56: 28-33. 10.2302/kjm.56.28.CrossRefPubMed
26.
Bemben DA, Palmer IJ, Bemben MG, Knehans AW: Effects of combined whole-body vibration and resistance training on muscular strength and bone metabolism in postmenopausal women. Bone. 2010, 47 (3): 650-656. 10.1016/j.bone.2010.06.019.CrossRefPubMed
27.
Prioreschi A, Oosthuyse T, Avidon I, Mcveigh J: Whole body vibration increases hip bone mineral density in road cyclists. Int J Sports Med. 2012, 33: 593-599.CrossRefPubMed
28.
Ward K, Alsop C, Caulton J, Rubin C, Adams J, Mughal Z: Low magnitude mechanical loading is osteogenic in children with disabling conditions. J Bone Miner Res. 2004, 19 (3): 360-369. 10.1359/JBMR.040129.CrossRefPubMed
29.
30.
Cardinale M, Wakeling J: Whole body vibration exercise: are vibrations good for you?. Br J Sports Med. 2005, 39 (9): 585-589. 10.1136/bjsm.2005.016857.CrossRefPubMedPubMedCentral
31.
Trans T, Aaboe J, Henriksen M, Christensen R, Bliddal H, Lund H: Effect of whole body vibration exercise on muscle strength and proprioception in females with knee osteoarthritis. Knee. 2009, 16 (4): 256-261. 10.1016/j.knee.2008.11.014.CrossRefPubMed
32.
Alentorn-Geli E, Padilla J, Moras G, Lázaro Haro C, Fernández-Solà J: Six weeks of whole-body vibration exercise improves pain and fatigue in women with fibromyalgia. J Altern Complement Med. 2008, 14 (8): 975-981. 10.1089/acm.2008.0050.CrossRefPubMed
33.
Torvinen S, Kannus P, Sievänen H, Järvinen TAH, Pasanen M, Kontulainen S, Nenonen A, Jarvinen TLN, Paakkala T, Jarvinen M, Vuori I: Effect of 8-month vertical whole body vibration on bone, muscle performance, and body balance: a randomized controlled study. J Bone Miner Res. 2003, 18 (5): 876-884. 10.1359/jbmr.2003.18.5.876.CrossRefPubMed
34.
Chanou K, Gerodimos V, Karatrantou K, Jamurtas A: Whole-body vibration and rehabilitation of chronic diseases: a review of the literature. J Sports Sci Med. 2012, 11: 187-200.PubMedPubMedCentral
35.
Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, Healey LA, Kaplan SR, Liang MH, Luthra HS, Medsger TA, Mitchell DM, Neustadt DH, Pinals RS, Schaller JG, Sharp JT, Wilder RL, Hunder GG: The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum. 1988, 31 (3): 315-324. 10.1002/art.1780310302.CrossRefPubMed
36.
Redelmeier D, Lorig K: Assessing the clinical importance of symptom. Arch Intern Med. 1993, 145: 1337-1342.CrossRef
37.
Bruce B, Fries JF: The health assessment questionnaire (HAQ). Clin Exp Rheumatol. 2005, 23: 14-18.
38.
Haugeberg G, Orstavik RE, Uhlig T, Falch JA, Halse JI, Kvien TK: Bone loss in patients with rheumatoid arthritis. Arthritis Rheum. 2002, 46: 1720-1728. 10.1002/art.10408.CrossRefPubMed
39.
De Jong Z, Munneke M, Lems WF, Zwinderman AH, Kroon HM, Pauwels EK, Jansen A, Ronday KH, Dijkmans BA, Breedeveld FC, Vliet Vlieland TP, Hazes JM: Slowing of bone loss in patients with rheumatoid arthritis by long-term, high-intensity exercise. Arthritis Rheum. 2004, 50: 1066-1076. 10.1002/art.20117.CrossRefPubMed
40.
Ellingson L, Colbert L, Cook D: Physical activity is related to pain sensitivity in healthy women. Med Sci Sport Exerc. 2012, doi:10.1249/MS:1401–6
41.
Tudor-locke C, Brashear MM, Johnson WD, Katzmarzyk PT: Accelerometer profiles of physical activity and inactivity in normal weight, overweight, and obese U.S. men and women. Int J Behav Nutr Phy Act. 2010, 7: 60-10.1186/1479-5868-7-60. doi:10.1186/1479-5868-7-60CrossRef
42.
Aletaha D, Smolen J: The Simplified Disease Activity Index (SDAI) and the Clinical Disease Activity Index (CDAI): a review of their usefulness and validity in rheumatoid arthritis. Clin Exp Rheumatol. 2005, 23: 100-108.
43.
Linke S, Gallo L, Norman G: Attrition and adherence rates of sustained vs. intermittent exercise interventions. Annals Behav Med. 2011, 42: 197-209. 10.1007/s12160-011-9279-8.CrossRef
Metadata
Title
A three month controlled intervention of intermittent whole body vibration designed to improve functional ability and attenuate bone loss in patients with rheumatoid arthritis
Authors
Alessandra Prioreschi
Mohammed Tikly
Joanne A McVeigh
Publication date
01-12-2014
Publisher
BioMed Central
Published in
BMC Musculoskeletal Disorders / Issue 1/2014
Electronic ISSN: 1471-2474
DOI
https://doi.org/10.1186/1471-2474-15-403

Other articles of this Issue 1/2014

BMC Musculoskeletal Disorders 1/2014 Go to the issue

Research article

Lateral insertion is a good prognostic factor after in situ fixation in slipped capital femoral epiphysis

Research article

Frailty index of deficit accumulation and falls: data from the Global Longitudinal Study of Osteoporosis in Women (GLOW) Hamilton cohort

Research article

Minimal detectable change for mobility and patient-reported tools in people with osteoarthritis awaiting arthroplasty

Case report

Treatment of osteoblastoma at C3-4 in a child: a case report

Research article

Comparative effectiveness of ultrasound and paraffin therapy in patients with carpal tunnel syndrome: a randomized trial

Research article

Preliminary study of the Southampton Hand Assessment Procedure for Children and its reliability