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Published in: BMC Musculoskeletal Disorders 1/2013

Open Access 01-12-2013 | Study protocol

European project on osteoarthritis: design of a six-cohort study on the personal and societal burden of osteoarthritis in an older European population

Authors: Suzan van der Pas, Maria Victoria Castell, Cyrus Cooper, Michael Denkinger, Elaine M Dennison, Mark H Edwards, Florian Herbolsheimer, Federica Limongi, Paul Lips, Stefania Maggi, Hans Nasell, Thorsten Nikolaus, Angel Otero, Nancy L Pedersen, Richard Peter, Mercedes Sanchez-Martinez, Laura A Schaap, Sabina Zambon, Natasja M van Schoor, Dorly JH Deeg

Published in: BMC Musculoskeletal Disorders | Issue 1/2013

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Abstract

Background

Osteoarthritis (OA), the most common form of arthritis, is a major contributor to functional impairment and loss of independence in older persons. The European Project on OSteoArthritis (EPOSA) is a collaborative study involving six European cohort studies on ageing. This project focuses on the personal and societal burden and its determinants of osteoarthritis. This paper describes the design of the project, and presents some descriptive analyses on selected variables across countries.

Methods/design

EPOSA is an observational study including pre-harmonized data from European cohort studies (Germany, Italy, the Netherlands, Spain, Sweden and the United Kingdom) on older community-dwelling persons aged 65 to 85 years. In total, 2942 persons were included in the baseline study with a mean age of 74.2 years (SD 5.1), just over half were women (51,9%). The baseline assessment was conducted by a face-to-face interview followed by a clinical examination. Measures included physical, cognitive, psychological and social functioning, lifestyle behaviour, physical environment, wellbeing and care utilisation. The clinical examination included anthropometry, muscle strength, physical performance and OA exam. A follow-up assessment was performed 12–18 months after baseline.

Discussion

The EPOSA study is the first population-based study including a clinical examination of OA, using pre-harmonized data across European countries. The EPOSA study provides a unique opportunity to study the determinants and consequences of OA in general populations of older persons, including both care-seeking and non care-seeking persons.
Literature
1.
2.
3.
go back to reference Pereira D, Peleteiro B, Araujo J, Branco J, Santos RA, Ramos E: The effect of osteoarthritis definition on prevalence and incidence estimates: a systematic review. Osteoarthr Cartil. 2011, 19: 1270-1285. 10.1016/j.joca.2011.08.009.CrossRefPubMed Pereira D, Peleteiro B, Araujo J, Branco J, Santos RA, Ramos E: The effect of osteoarthritis definition on prevalence and incidence estimates: a systematic review. Osteoarthr Cartil. 2011, 19: 1270-1285. 10.1016/j.joca.2011.08.009.CrossRefPubMed
5.
go back to reference Dawson J, Linsell I, Zondervan K, Rose P, Randall T, Carr A: Epidemiology of hip and knee pain and its impact on overall health status in older adults. Rheumatology (Oxford). 2004, 43: 497-504. 10.1093/rheumatology/keh086.CrossRef Dawson J, Linsell I, Zondervan K, Rose P, Randall T, Carr A: Epidemiology of hip and knee pain and its impact on overall health status in older adults. Rheumatology (Oxford). 2004, 43: 497-504. 10.1093/rheumatology/keh086.CrossRef
6.
go back to reference Mannoni A, Briganti MP, Di BM, Ferrucci L, Costanzo A, Serni U, Masotti G, Marchionni N: Epidemiological profile of symptomatic osteoarthritis in older adults: a population based study in Dicomano, Italy. Ann Rheum Dis. 2003, 62: 576-578. 10.1136/ard.62.6.576.CrossRefPubMedPubMedCentral Mannoni A, Briganti MP, Di BM, Ferrucci L, Costanzo A, Serni U, Masotti G, Marchionni N: Epidemiological profile of symptomatic osteoarthritis in older adults: a population based study in Dicomano, Italy. Ann Rheum Dis. 2003, 62: 576-578. 10.1136/ard.62.6.576.CrossRefPubMedPubMedCentral
7.
go back to reference Carona L, Ballina J, Gabriel R, Laffon A: The burden of musculoskeletal diseases in the general population of spain: results from a national survey. Ann Rheum Dis. 2001, 60: 1040-1045. 10.1136/ard.60.11.1040.CrossRef Carona L, Ballina J, Gabriel R, Laffon A: The burden of musculoskeletal diseases in the general population of spain: results from a national survey. Ann Rheum Dis. 2001, 60: 1040-1045. 10.1136/ard.60.11.1040.CrossRef
8.
go back to reference Zhang W, Doherty M, Peat G, Bierma-Zeinstra SM, Arden NK, Bresnihan B: EULAR evidence based recommendations for the diagnosis of knee osteoarthritis. Ann Rheum Dis. 2010, 69: 483-489. 10.1136/ard.2009.113100.CrossRefPubMed Zhang W, Doherty M, Peat G, Bierma-Zeinstra SM, Arden NK, Bresnihan B: EULAR evidence based recommendations for the diagnosis of knee osteoarthritis. Ann Rheum Dis. 2010, 69: 483-489. 10.1136/ard.2009.113100.CrossRefPubMed
9.
go back to reference Zhang W, Doherty M, Leeb BF, Alekseeva L, Arden NK, Bijlsma JW: EULAR evidence-based recommendations for the diagnosis of hand osteoarthritis: report of a task force of ESCISIT. Ann Rheum Dis. 2009, 68: 8-17.CrossRefPubMed Zhang W, Doherty M, Leeb BF, Alekseeva L, Arden NK, Bijlsma JW: EULAR evidence-based recommendations for the diagnosis of hand osteoarthritis: report of a task force of ESCISIT. Ann Rheum Dis. 2009, 68: 8-17.CrossRefPubMed
10.
go back to reference Schaap LA, Peeters GMEE, Denisson EM, Zambon S, Nikolaus T, Sanchez-Martinez M, Musacchio E, Van Schoor NM, Deeg DJH, The EPOSA research Group: European Project on Osteoarthritis (EPOSA): methodological challenges in harmonization of existing data from five European population-based cohorts on aging. BMC Musculoskelet Disord. 2011, 12: 272-10.1186/1471-2474-12-272.CrossRefPubMedPubMedCentral Schaap LA, Peeters GMEE, Denisson EM, Zambon S, Nikolaus T, Sanchez-Martinez M, Musacchio E, Van Schoor NM, Deeg DJH, The EPOSA research Group: European Project on Osteoarthritis (EPOSA): methodological challenges in harmonization of existing data from five European population-based cohorts on aging. BMC Musculoskelet Disord. 2011, 12: 272-10.1186/1471-2474-12-272.CrossRefPubMedPubMedCentral
11.
go back to reference Denkinger MD, Franke S, Rapp K, Weinmayr G, Duran-Tauleria E, Nikolaus T: Accelerometer-based physical activity in a large observational cohort--study protocol and design of the activity and function of the elderly in Ulm (ActiFE Ulm) study. BMC Geriatr. 2010, 10: 50-10.1186/1471-2318-10-50.CrossRefPubMedPubMedCentral Denkinger MD, Franke S, Rapp K, Weinmayr G, Duran-Tauleria E, Nikolaus T: Accelerometer-based physical activity in a large observational cohort--study protocol and design of the activity and function of the elderly in Ulm (ActiFE Ulm) study. BMC Geriatr. 2010, 10: 50-10.1186/1471-2318-10-50.CrossRefPubMedPubMedCentral
12.
go back to reference Huisman M, Poppelaars J, Van der Horst M, Beekman ATF, Brug J, Van Tilburg TG, Deeg DJH: Cohort profile: the longitudinal aging study Amsterdam (LASA). Int J Epidemiol. 2011, 40: 868-876. 10.1093/ije/dyq219.CrossRefPubMed Huisman M, Poppelaars J, Van der Horst M, Beekman ATF, Brug J, Van Tilburg TG, Deeg DJH: Cohort profile: the longitudinal aging study Amsterdam (LASA). Int J Epidemiol. 2011, 40: 868-876. 10.1093/ije/dyq219.CrossRefPubMed
13.
go back to reference Castell MV, Otero Á, Sanchez-Santos MT, Garrido A, Gonzalez-Montalvo JJ, Zunzunegui MV: Prevalencia de fragilidad en una población urbana de mayores de 65 años y su relación con comorbilidad y discapacidad. Atencion Primaria. 2010, 42 (10): 520-527. 10.1016/j.aprim.2009.09.024.CrossRef Castell MV, Otero Á, Sanchez-Santos MT, Garrido A, Gonzalez-Montalvo JJ, Zunzunegui MV: Prevalencia de fragilidad en una población urbana de mayores de 65 años y su relación con comorbilidad y discapacidad. Atencion Primaria. 2010, 42 (10): 520-527. 10.1016/j.aprim.2009.09.024.CrossRef
14.
go back to reference Lichtenstein P, Sullivan PF, Cnattingius S, Gatz M, Johansson S, Carlström E, Pedersen NL: The Swedish twin registry in the third millennium - an update. Twin Res Hum Genet. 2006, 9 (6): 875-882. 10.1375/twin.9.6.875.CrossRefPubMed Lichtenstein P, Sullivan PF, Cnattingius S, Gatz M, Johansson S, Carlström E, Pedersen NL: The Swedish twin registry in the third millennium - an update. Twin Res Hum Genet. 2006, 9 (6): 875-882. 10.1375/twin.9.6.875.CrossRefPubMed
15.
go back to reference Syddall HE, Aihie SA, Dennison EM, Martin HJ, Barker DJ, Cooper C: Cohort profile: the Hertfordshire cohort study. Int J Epidemiol. 2005, 34: 1234-1242. 10.1093/ije/dyi127.CrossRefPubMed Syddall HE, Aihie SA, Dennison EM, Martin HJ, Barker DJ, Cooper C: Cohort profile: the Hertfordshire cohort study. Int J Epidemiol. 2005, 34: 1234-1242. 10.1093/ije/dyi127.CrossRefPubMed
16.
go back to reference Altman R: Classification of disease: osteoarthritis. Seminars in Arthritis & Rheum. 1991, 20: 40-47. 10.1016/0049-0172(91)90026-V.CrossRef Altman R: Classification of disease: osteoarthritis. Seminars in Arthritis & Rheum. 1991, 20: 40-47. 10.1016/0049-0172(91)90026-V.CrossRef
17.
go back to reference Bellamy N: WOMAC osteoarthritis index: a user’s guide. 1996, Ontario: London Health Services Centre Bellamy N: WOMAC osteoarthritis index: a user’s guide. 1996, Ontario: London Health Services Centre
18.
go back to reference Bellamy N: Clinimetric properties of the AUSCAN Osteoarthritis Hand Index: an evaluation of reliability, validity and responsiveness. Osteoarthr Cartil. 2002, 10: 863-869. 10.1053/joca.2002.0838.CrossRefPubMed Bellamy N: Clinimetric properties of the AUSCAN Osteoarthritis Hand Index: an evaluation of reliability, validity and responsiveness. Osteoarthr Cartil. 2002, 10: 863-869. 10.1053/joca.2002.0838.CrossRefPubMed
19.
go back to reference Veenhof C, Bijlsma JWJ, van den Ende CHM, van Dijk GM, Pisters MF, Dekker J: Psychometric evaluation of osteoarthritis questionnaires: a systematic review of the literature. Arthritis Rheum. 2006, 55: 480-492. 10.1002/art.22001.CrossRefPubMed Veenhof C, Bijlsma JWJ, van den Ende CHM, van Dijk GM, Pisters MF, Dekker J: Psychometric evaluation of osteoarthritis questionnaires: a systematic review of the literature. Arthritis Rheum. 2006, 55: 480-492. 10.1002/art.22001.CrossRefPubMed
20.
go back to reference Goggins J, Baker K, Felson D: What WOMAC pain score should make a patient eligible for a trial in knee osteoarthritis?. J Rheumatology. 2005, 32: 540-542. Goggins J, Baker K, Felson D: What WOMAC pain score should make a patient eligible for a trial in knee osteoarthritis?. J Rheumatology. 2005, 32: 540-542.
21.
go back to reference Stel VS, Smit JH, Pluijm SM, Visser M, Deeg DJ, Lips P: Comparison of the LASA Physical Activity Questionnaire with a 7-day diary and pedometer. J Clin Epidemiol. 2004, 57 (3): 252-258. 10.1016/j.jclinepi.2003.07.008.CrossRefPubMed Stel VS, Smit JH, Pluijm SM, Visser M, Deeg DJ, Lips P: Comparison of the LASA Physical Activity Questionnaire with a 7-day diary and pedometer. J Clin Epidemiol. 2004, 57 (3): 252-258. 10.1016/j.jclinepi.2003.07.008.CrossRefPubMed
22.
go back to reference Lubben J, Blozik E, Gillmann G, Iliffe S, von Renteln Kruse W, Beck JC, Stuck AE: Performance of an abbreviated version of the Lubben Social Network Scale among three European community dwelling older adult populations. Gerontologist. 2006, 46: 503-513. 10.1093/geront/46.4.503.CrossRefPubMed Lubben J, Blozik E, Gillmann G, Iliffe S, von Renteln Kruse W, Beck JC, Stuck AE: Performance of an abbreviated version of the Lubben Social Network Scale among three European community dwelling older adult populations. Gerontologist. 2006, 46: 503-513. 10.1093/geront/46.4.503.CrossRefPubMed
23.
go back to reference Mars GMJ, Kempen GIJM, Post MWM, Proot IM, Mesters I, van Eijk JTM: The Maastricht social participation profile: development and clinimetric properties in older adults with a chronic physical illness. Qual Life Res. 2009, 18: 1207-1218. 10.1007/s11136-009-9537-4.CrossRefPubMed Mars GMJ, Kempen GIJM, Post MWM, Proot IM, Mesters I, van Eijk JTM: The Maastricht social participation profile: development and clinimetric properties in older adults with a chronic physical illness. Qual Life Res. 2009, 18: 1207-1218. 10.1007/s11136-009-9537-4.CrossRefPubMed
24.
go back to reference Van Bakel WH, Anderson AM, Mutatkar RK, Bakirtzief Z, Nicholls PG, Raju MS, Das-Pattananyak RK: The participation scale: measuring a key concept in public health. Disabil Rehabil. 2006, 28: 193-203. 10.1080/09638280500192785.CrossRef Van Bakel WH, Anderson AM, Mutatkar RK, Bakirtzief Z, Nicholls PG, Raju MS, Das-Pattananyak RK: The participation scale: measuring a key concept in public health. Disabil Rehabil. 2006, 28: 193-203. 10.1080/09638280500192785.CrossRef
25.
go back to reference Tombaugh TN, McIntyre NJ: The mini mental state examination: a comprehensive review. J Am Geriatr Soc. 1992, 40: 922-935.CrossRefPubMed Tombaugh TN, McIntyre NJ: The mini mental state examination: a comprehensive review. J Am Geriatr Soc. 1992, 40: 922-935.CrossRefPubMed
26.
go back to reference Lobo A, Saz P, Marcos G, Dia JL, de la Cámara C, Ventura T, Morales Asin F, Fernando Pascual L, Montañés JA, Aznar S: Revalidation and standardization of the cognitionmini-exam (first Spanish version of the Mini-Mental State Examination) in the general population. Med Clin (Barc). 1999, 112 (20): 767-774. Lobo A, Saz P, Marcos G, Dia JL, de la Cámara C, Ventura T, Morales Asin F, Fernando Pascual L, Montañés JA, Aznar S: Revalidation and standardization of the cognitionmini-exam (first Spanish version of the Mini-Mental State Examination) in the general population. Med Clin (Barc). 1999, 112 (20): 767-774.
27.
go back to reference Magni E, Binetti G, Bianchetti R, Rozzini R, Trabucchi M: Mini-mental state examination: a normative study in Italian elderly population. Eur J Neurol. 1996, 3: 198-202. 10.1111/j.1468-1331.1996.tb00423.x.CrossRefPubMed Magni E, Binetti G, Bianchetti R, Rozzini R, Trabucchi M: Mini-mental state examination: a normative study in Italian elderly population. Eur J Neurol. 1996, 3: 198-202. 10.1111/j.1468-1331.1996.tb00423.x.CrossRefPubMed
28.
go back to reference Gatz M, Reynolds C, John R, Johansson B, Mortimer J, Pedersen NL: Telephone screening to identify potential dementia cases in a population-based sample of older adults. Int Psychogeriatr. 2002, 14: 273-289. 10.1017/S1041610202008475.CrossRefPubMed Gatz M, Reynolds C, John R, Johansson B, Mortimer J, Pedersen NL: Telephone screening to identify potential dementia cases in a population-based sample of older adults. Int Psychogeriatr. 2002, 14: 273-289. 10.1017/S1041610202008475.CrossRefPubMed
29.
go back to reference Zigmond A, Snaith R: The hospital anxiety and depression scale. Acta Psychiatr Scand. 1983, 67: 361-370. 10.1111/j.1600-0447.1983.tb09716.x.CrossRefPubMed Zigmond A, Snaith R: The hospital anxiety and depression scale. Acta Psychiatr Scand. 1983, 67: 361-370. 10.1111/j.1600-0447.1983.tb09716.x.CrossRefPubMed
30.
go back to reference Pearlin LI, Schooler C: The structure of coping. J Health Soc Behav. 1978, 19: 2-21. 10.2307/2136319.CrossRefPubMed Pearlin LI, Schooler C: The structure of coping. J Health Soc Behav. 1978, 19: 2-21. 10.2307/2136319.CrossRefPubMed
31.
go back to reference The Measurement and Valuation of Health Status Using EQ-5D: A European Perspective. Edited by: Brooks R, Rabin R, Charro F De. 2003, Dordrecht: Kluwer Academic Publishers The Measurement and Valuation of Health Status Using EQ-5D: A European Perspective. Edited by: Brooks R, Rabin R, Charro F De. 2003, Dordrecht: Kluwer Academic Publishers
32.
go back to reference van Sonsbeek JLA: Het Eigen oordeel over de gezondheid; methodische effecten bij het gezondheidsoordeel in gezondheidsenquêtes [The self-rating of health: methodological effects of the rating of health in health interview surveys]. Maandbericht Gezondheid. 1991, 10: 15-23. van Sonsbeek JLA: Het Eigen oordeel over de gezondheid; methodische effecten bij het gezondheidsoordeel in gezondheidsenquêtes [The self-rating of health: methodological effects of the rating of health in health interview surveys]. Maandbericht Gezondheid. 1991, 10: 15-23.
33.
go back to reference White DK, Jette AM, Felson DT, Lavalley MP, Lewis CE, Torner JC, Nevitt MC, Keysor JJ: Are features of the neighborhood environment associated with disability in older adults?. Disabil Rehabil. 2010, 32: 639-645. 10.3109/09638280903254547.CrossRefPubMedPubMedCentral White DK, Jette AM, Felson DT, Lavalley MP, Lewis CE, Torner JC, Nevitt MC, Keysor JJ: Are features of the neighborhood environment associated with disability in older adults?. Disabil Rehabil. 2010, 32: 639-645. 10.3109/09638280903254547.CrossRefPubMedPubMedCentral
34.
go back to reference Guralnik JM, Branch LG, Cummings SR, Curb D: Physical performance measures in aging research. J Gerontol: Med Sci. 1989, 44: 141-146. 10.1093/geronj/44.5.M141.CrossRef Guralnik JM, Branch LG, Cummings SR, Curb D: Physical performance measures in aging research. J Gerontol: Med Sci. 1989, 44: 141-146. 10.1093/geronj/44.5.M141.CrossRef
35.
go back to reference Minicuci N, Noale M, Bardage C, Blumstein T, Deeg DJ, Gindin J: Crossnational determinants of quality of life from six longitudinal studies on aging: the CLESA project. Aging Clin Exp Res. 2003, 15: 187-202.CrossRefPubMed Minicuci N, Noale M, Bardage C, Blumstein T, Deeg DJ, Gindin J: Crossnational determinants of quality of life from six longitudinal studies on aging: the CLESA project. Aging Clin Exp Res. 2003, 15: 187-202.CrossRefPubMed
37.
go back to reference Kinds MB, Welsing PMJ, Vignon EP, Bijlsma JWJ, Viergever MA, Marijnissen ACA, Lafeber FPJG: A systematic review of the association between radiographic and clinical osteoarthritis of hip and knee. Osteoarthr Cartil. 2011, 19: 768-778. 10.1016/j.joca.2011.01.015.CrossRefPubMed Kinds MB, Welsing PMJ, Vignon EP, Bijlsma JWJ, Viergever MA, Marijnissen ACA, Lafeber FPJG: A systematic review of the association between radiographic and clinical osteoarthritis of hip and knee. Osteoarthr Cartil. 2011, 19: 768-778. 10.1016/j.joca.2011.01.015.CrossRefPubMed
38.
go back to reference Bath PA, Deeg D, Poppelaars J: The harmonisation of longitudinal data: a case study using data from cohort studies in The Netherlands and the United Kingdom. Ageing and Society. 2010, 30: 1419-1437. 10.1017/S0144686X1000070X.CrossRef Bath PA, Deeg D, Poppelaars J: The harmonisation of longitudinal data: a case study using data from cohort studies in The Netherlands and the United Kingdom. Ageing and Society. 2010, 30: 1419-1437. 10.1017/S0144686X1000070X.CrossRef
Metadata
Title
European project on osteoarthritis: design of a six-cohort study on the personal and societal burden of osteoarthritis in an older European population
Authors
Suzan van der Pas
Maria Victoria Castell
Cyrus Cooper
Michael Denkinger
Elaine M Dennison
Mark H Edwards
Florian Herbolsheimer
Federica Limongi
Paul Lips
Stefania Maggi
Hans Nasell
Thorsten Nikolaus
Angel Otero
Nancy L Pedersen
Richard Peter
Mercedes Sanchez-Martinez
Laura A Schaap
Sabina Zambon
Natasja M van Schoor
Dorly JH Deeg
Publication date
01-12-2013
Publisher
BioMed Central
Published in
BMC Musculoskeletal Disorders / Issue 1/2013
Electronic ISSN: 1471-2474
DOI
https://doi.org/10.1186/1471-2474-14-138

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