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Published in: BMC Musculoskeletal Disorders 1/2012

Open Access 01-12-2012 | Research article

“Burden of osteoporotic fractures in primary health care in Catalonia (Spain): a population-based study”

Authors: Aina Pagès-Castellà, Cristina Carbonell-Abella, Francesc Fina Avilés, Maite Alzamora, Jose Miguel Baena-Díez, Daniel Martínez Laguna, Xavier Nogués, Adolfo Díez-Pérez, Daniel Prieto-Alhambra

Published in: BMC Musculoskeletal Disorders | Issue 1/2012

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Abstract

Background

Knowledge on the epidemiology of non-hip fractures in Spain is limited and somewhat outdated. Using computerized primary care records from the SIDIAP database, we derived age and sex-specific fracture incidence rates for the region of Catalonia during the year 2009.

Methods

The SIDIAP database contains quality-checked clinical information from computerized medical records of a representative sample of >5,800,000 patients (80% of the population of Catalonia). We conducted a retrospective cohort study including all patients aged ≥50 years, and followed them from January 1 to December 31, 2009. Major osteoporotic fractures registered in SIDIAP were ascertained using ICD-10 codes and validated by comparing data to hospital admission and patient-reported fractures records. Incidence rates and 95% confidence intervals were calculated.

Results

In total, 2,011,430 subjects were studied (54.6% women). Overall fracture rates were 10.91/1,000 person-years (py) [95%CI 10.89–10.92]: 15.18/1,000 py [15.15–15.21] in women and 5.78/1,000 py [5.76–5.79] in men. The most common fracture among women was wrist/forearm (3.86/1,000 py [3.74–3.98]), while among men it was clinical spine (1.25/1,000 py [1.18–1.33]). All fracture rates increased with age, but varying patterns were observed: while most of the fractures (hip, proximal humerus, clinical spine and pelvis) increased continuously with age, wrist and multiple rib fractures peaked at age 75–80 and then reached a plateau.

Conclusions

Our study provides local estimates of age, sex and site-specific fracture burden in primary health care, which will be helpful for health-care planning and delivery. A proportion of fractures are not reported in primary care records, leading to underestimation of fracture incidence rates in these data.
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Literature
1.
go back to reference Harvey N, Dennison E, Cooper C: Osteoporosis: impact on health and economics. Nat Rev Rheumatol. 2010, 6 (2): 99-105. 10.1038/nrrheum.2009.260.CrossRefPubMed Harvey N, Dennison E, Cooper C: Osteoporosis: impact on health and economics. Nat Rev Rheumatol. 2010, 6 (2): 99-105. 10.1038/nrrheum.2009.260.CrossRefPubMed
2.
go back to reference Johnell O, Gullberg B, Allander E, Kanis JA: The apparent incidence of hip fracture in Europe: a study of national register Sources. Medos study group. Osteoporos Int. 1992, 2 (6): 298-302. 10.1007/BF01623186.CrossRefPubMed Johnell O, Gullberg B, Allander E, Kanis JA: The apparent incidence of hip fracture in Europe: a study of national register Sources. Medos study group. Osteoporos Int. 1992, 2 (6): 298-302. 10.1007/BF01623186.CrossRefPubMed
3.
go back to reference Cooper C, Cole ZA, Holroyd CR, Earl SC, Harvey NC, Dennison EM, Melton LJ, Cummings SR, Kanis JA: Secular trends in the incidence of hip and other osteoporotic fractures. Osteoporos Int. 2011, 22 (5): 1277-1288. 10.1007/s00198-011-1601-6.CrossRefPubMedPubMedCentral Cooper C, Cole ZA, Holroyd CR, Earl SC, Harvey NC, Dennison EM, Melton LJ, Cummings SR, Kanis JA: Secular trends in the incidence of hip and other osteoporotic fractures. Osteoporos Int. 2011, 22 (5): 1277-1288. 10.1007/s00198-011-1601-6.CrossRefPubMedPubMedCentral
4.
go back to reference Alvarez-Nebreda ML, Jimenez AB, Rodriguez P, Serra JA: Epidemiology of hip fracture in the elderly in Spain. Bone. 2008, 42 (2): 278-285. 10.1016/j.bone.2007.10.001.CrossRefPubMed Alvarez-Nebreda ML, Jimenez AB, Rodriguez P, Serra JA: Epidemiology of hip fracture in the elderly in Spain. Bone. 2008, 42 (2): 278-285. 10.1016/j.bone.2007.10.001.CrossRefPubMed
5.
go back to reference Hernandez JL, Olmos JM, Alonso MA, Gonzalez-Fernandez CR, Martinez J, Pajaron M, Llorca J, Gonzalez-Macias J: Trend in hip fracture epidemiology over a 14-year period in a spanish population. Osteoporos Int. 2006, 17 (3): 464-470. 10.1007/s00198-005-0008-7.CrossRefPubMed Hernandez JL, Olmos JM, Alonso MA, Gonzalez-Fernandez CR, Martinez J, Pajaron M, Llorca J, Gonzalez-Macias J: Trend in hip fracture epidemiology over a 14-year period in a spanish population. Osteoporos Int. 2006, 17 (3): 464-470. 10.1007/s00198-005-0008-7.CrossRefPubMed
6.
go back to reference Diez A, Puig J, Martinez MT, Diez JL, Aubia J, Vivancos J: Epidemiology of fractures of the proximal femur associated with osteoporosis in Barcelona, Spain. Calcif Tissue Int. 1989, 44 (6): 382-386. 10.1007/BF02555965.CrossRefPubMed Diez A, Puig J, Martinez MT, Diez JL, Aubia J, Vivancos J: Epidemiology of fractures of the proximal femur associated with osteoporosis in Barcelona, Spain. Calcif Tissue Int. 1989, 44 (6): 382-386. 10.1007/BF02555965.CrossRefPubMed
7.
go back to reference Diez Perez A, Puig Manresa J, Martinez Izquierdo MT, Guelar Grimberg AM, Cucurull Canosa J, Mellibovsky Saidler L, Vivancos Lleida J: Estimate of the costs of osteoporotic fractures of the femur in Spain. Med Clin (Barc). 1989, 92 (19): 721-723. Diez Perez A, Puig Manresa J, Martinez Izquierdo MT, Guelar Grimberg AM, Cucurull Canosa J, Mellibovsky Saidler L, Vivancos Lleida J: Estimate of the costs of osteoporotic fractures of the femur in Spain. Med Clin (Barc). 1989, 92 (19): 721-723.
8.
go back to reference Le W: The role of the primary care physician in diagnosis and management of osteoporosis. Int J Fertil Womens Med. 2002, 47 (3): 116-122. Le W: The role of the primary care physician in diagnosis and management of osteoporosis. Int J Fertil Womens Med. 2002, 47 (3): 116-122.
9.
go back to reference Cree M, Yang Q, Sclater A, Johnson D, Carriere KC: Continuity of care and health decline associated with a hip fracture. J Aging Health. 2002, 14 (3): 385-398. 10.1177/08964302014003005.CrossRefPubMed Cree M, Yang Q, Sclater A, Johnson D, Carriere KC: Continuity of care and health decline associated with a hip fracture. J Aging Health. 2002, 14 (3): 385-398. 10.1177/08964302014003005.CrossRefPubMed
10.
go back to reference Martinez Laguna D, Farran Aragones A, Crespo Lessmann AC: Risk of fractures in women over 65 years old at a primary care center. Aten Primaria. 2007, 39 (7): 380-381. 10.1157/13107730.CrossRefPubMed Martinez Laguna D, Farran Aragones A, Crespo Lessmann AC: Risk of fractures in women over 65 years old at a primary care center. Aten Primaria. 2007, 39 (7): 380-381. 10.1157/13107730.CrossRefPubMed
11.
go back to reference Mcgowan BM, Bennett K, Marry J, Walsh JB, Casey MC: Primary-care prescribing of anti-osteoporotic-type medications following hospitalisation for fractures. Eur J Clin Pharmacol. 2010, 67 (3): 301-308.CrossRefPubMed Mcgowan BM, Bennett K, Marry J, Walsh JB, Casey MC: Primary-care prescribing of anti-osteoporotic-type medications following hospitalisation for fractures. Eur J Clin Pharmacol. 2010, 67 (3): 301-308.CrossRefPubMed
12.
go back to reference Van Staa TP, Abenhaim L, Cooper C, Zhang B, Leufkens HG: The use of a large pharmacoepidemiological database to study exposure to oral corticosteroids and risk of fractures: validation of study population and results. Pharmacoepidemiol Drug Saf. 2000, 9 (5): 359-366. 10.1002/1099-1557(200009/10)9:5<359::AID-PDS507>3.0.CO;2-E.CrossRefPubMed Van Staa TP, Abenhaim L, Cooper C, Zhang B, Leufkens HG: The use of a large pharmacoepidemiological database to study exposure to oral corticosteroids and risk of fractures: validation of study population and results. Pharmacoepidemiol Drug Saf. 2000, 9 (5): 359-366. 10.1002/1099-1557(200009/10)9:5<359::AID-PDS507>3.0.CO;2-E.CrossRefPubMed
13.
go back to reference Cooper C, Dennison EM, Leufkens HG, Bishop N, Van Staa TP: Epidemiology of childhood fractures in britain: a study using the general practice research database. J Bone Miner Res. 2004, 19 (12): 1976-1981. 10.1359/jbmr.040902.CrossRefPubMed Cooper C, Dennison EM, Leufkens HG, Bishop N, Van Staa TP: Epidemiology of childhood fractures in britain: a study using the general practice research database. J Bone Miner Res. 2004, 19 (12): 1976-1981. 10.1359/jbmr.040902.CrossRefPubMed
14.
go back to reference Vestergaard P, Mosekilde L: Fracture risk in patients with celiac disease, crohn’s disease, and ulcerative colitis: a nationwide follow-up study of 16,416 patients in denmark. Am J Epidemiol. 2002, 156 (1): 1-10. 10.1093/aje/kwf007.CrossRefPubMed Vestergaard P, Mosekilde L: Fracture risk in patients with celiac disease, crohn’s disease, and ulcerative colitis: a nationwide follow-up study of 16,416 patients in denmark. Am J Epidemiol. 2002, 156 (1): 1-10. 10.1093/aje/kwf007.CrossRefPubMed
15.
go back to reference Vestergaard P, Mosekilde L: Fractures in patients with hyperthyroidism and hypothyroidism: a nationwide follow-up study in 16,249 patients. Thyroid. 2002, 12 (5): 411-419. 10.1089/105072502760043503.CrossRefPubMed Vestergaard P, Mosekilde L: Fractures in patients with hyperthyroidism and hypothyroidism: a nationwide follow-up study in 16,249 patients. Thyroid. 2002, 12 (5): 411-419. 10.1089/105072502760043503.CrossRefPubMed
16.
go back to reference Garcia-Gil M, Hermosilla E, Prieto-Alhambra D, Fina F, Rossell M, Ramos R, Rodriguez J, Williams T, Van Staa T, Bolibar B: Construction and validation of a scoring system for selction of high quality data in a spanish population primary care database (sidiap). Informatics In Primary Care. 2011, (Submitted) Garcia-Gil M, Hermosilla E, Prieto-Alhambra D, Fina F, Rossell M, Ramos R, Rodriguez J, Williams T, Van Staa T, Bolibar B: Construction and validation of a scoring system for selction of high quality data in a spanish population primary care database (sidiap). Informatics In Primary Care. 2011, (Submitted)
17.
go back to reference Ramos R, Balló E, Marrugat J, Elosúa R, Sala J, Grau M, Vila J, Bolibar B, Garcia-Gil M, Martí R, Fina F, Hermosilla E, Rosell M, Muñoz MA, Prieto-Alhambra D, Quesada M: Validity of the sidiap database for the study of cardio-vascular disease: the emma study. Rev Esp Cardiol. 2011, (In Press) Ramos R, Balló E, Marrugat J, Elosúa R, Sala J, Grau M, Vila J, Bolibar B, Garcia-Gil M, Martí R, Fina F, Hermosilla E, Rosell M, Muñoz MA, Prieto-Alhambra D, Quesada M: Validity of the sidiap database for the study of cardio-vascular disease: the emma study. Rev Esp Cardiol. 2011, (In Press)
18.
go back to reference Center JR, Nguyen TV, Schneider D, Sambrook PN, Eisman JA: Mortality after all major types of osteoporotic fracture in men and women: an observational study. Lancet. 1999, 353 (9156): 878-882. 10.1016/S0140-6736(98)09075-8.CrossRefPubMed Center JR, Nguyen TV, Schneider D, Sambrook PN, Eisman JA: Mortality after all major types of osteoporotic fracture in men and women: an observational study. Lancet. 1999, 353 (9156): 878-882. 10.1016/S0140-6736(98)09075-8.CrossRefPubMed
19.
go back to reference Alzamora MT, Baena-Diez JM, Sorribes M, Fores R, Toran P, Vicheto M, Pera G, Reina MD, Albaladejo C, Llussa J: Peripheral arterial disease study (perart): prevalence and predictive values of asymptomatic peripheral arterial occlusive disease related to cardiovascular morbidity and mortality. Bmc Public Health. 2007, 7: 348-10.1186/1471-2458-7-348.CrossRefPubMedPubMedCentral Alzamora MT, Baena-Diez JM, Sorribes M, Fores R, Toran P, Vicheto M, Pera G, Reina MD, Albaladejo C, Llussa J: Peripheral arterial disease study (perart): prevalence and predictive values of asymptomatic peripheral arterial occlusive disease related to cardiovascular morbidity and mortality. Bmc Public Health. 2007, 7: 348-10.1186/1471-2458-7-348.CrossRefPubMedPubMedCentral
20.
go back to reference Alzamora MT, Fores R, Baena-Diez JM, Pera G, Toran P, Sorribes M, Vicheto M, Reina MD, Sancho A, Albaladejo C: The peripheral arterial disease study (perart/artper): prevalence and risk factors in the general population. Bmc Public Health. 2010, 10: 38-10.1186/1471-2458-10-38.CrossRefPubMedPubMedCentral Alzamora MT, Fores R, Baena-Diez JM, Pera G, Toran P, Sorribes M, Vicheto M, Reina MD, Sancho A, Albaladejo C: The peripheral arterial disease study (perart/artper): prevalence and risk factors in the general population. Bmc Public Health. 2010, 10: 38-10.1186/1471-2458-10-38.CrossRefPubMedPubMedCentral
21.
go back to reference Ismail AA, O’neill TW, Cockerill W, Finn JD, Cannata JB, Hoszowski K, Johnell O, Matthis C, Raspe H, Raspe A: Validity of self-report of fractures: results from a prospective study in men and women across europe. epos study group. european prospective osteoporosis study group. Osteoporos Int. 2000, 11 (3): 248-254. 10.1007/s001980050288.CrossRefPubMed Ismail AA, O’neill TW, Cockerill W, Finn JD, Cannata JB, Hoszowski K, Johnell O, Matthis C, Raspe H, Raspe A: Validity of self-report of fractures: results from a prospective study in men and women across europe. epos study group. european prospective osteoporosis study group. Osteoporos Int. 2000, 11 (3): 248-254. 10.1007/s001980050288.CrossRefPubMed
22.
go back to reference Kirkwood BR, Sterne JAC: Longitudinal Studies: Analysis Of Rates And Survival Times. Medical Statistics. 2003, Science B, Cornwall, 238-239. 2 Kirkwood BR, Sterne JAC: Longitudinal Studies: Analysis Of Rates And Survival Times. Medical Statistics. 2003, Science B, Cornwall, 238-239. 2
23.
go back to reference Kanis JA, Johnell O, De Laet C, Jonsson B, Oden A, Ogelsby AK: International variations in hip fracture probabilities: implications for risk assessment. J Bone Miner Res. 2002, 17 (7): 1237-1244. 10.1359/jbmr.2002.17.7.1237.CrossRefPubMed Kanis JA, Johnell O, De Laet C, Jonsson B, Oden A, Ogelsby AK: International variations in hip fracture probabilities: implications for risk assessment. J Bone Miner Res. 2002, 17 (7): 1237-1244. 10.1359/jbmr.2002.17.7.1237.CrossRefPubMed
24.
go back to reference Naves Diaz M, Diaz Lopez JB, Gomez Alonso C, Altadill Arregui A, Rodriguez Rebollar A, Cannata Andia JB: Study Of Incidence Of Osteoporotic Fractures In A Cohort Of Individuals Older Than 50 Years From Asturias, Spain, After A 6 Year Follow-Up Period. Med Clin (Barc). 2000, 115 (17): 650-653.CrossRef Naves Diaz M, Diaz Lopez JB, Gomez Alonso C, Altadill Arregui A, Rodriguez Rebollar A, Cannata Andia JB: Study Of Incidence Of Osteoporotic Fractures In A Cohort Of Individuals Older Than 50 Years From Asturias, Spain, After A 6 Year Follow-Up Period. Med Clin (Barc). 2000, 115 (17): 650-653.CrossRef
25.
go back to reference Marin F, Gonzalez-Macias J, Moya R, Onrubia C, Cancelo C, Alvarez S, Montero JJ, Gomez F, Carbonell C, Vila J: Fragility non-spinal fractures in a cohort of 5,201 women aged 65 years and older during a 3-year follow-up. Med Clin (Barc). 2006, 127 (11): 401-404. 10.1157/13092764.CrossRef Marin F, Gonzalez-Macias J, Moya R, Onrubia C, Cancelo C, Alvarez S, Montero JJ, Gomez F, Carbonell C, Vila J: Fragility non-spinal fractures in a cohort of 5,201 women aged 65 years and older during a 3-year follow-up. Med Clin (Barc). 2006, 127 (11): 401-404. 10.1157/13092764.CrossRef
26.
go back to reference Van Staa TP, Dennison EM, Leufkens HG, Cooper C: Epidemiology of fractures in England and Wales. Bone. 2001, 29 (6): 517-522. 10.1016/S8756-3282(01)00614-7.CrossRefPubMed Van Staa TP, Dennison EM, Leufkens HG, Cooper C: Epidemiology of fractures in England and Wales. Bone. 2001, 29 (6): 517-522. 10.1016/S8756-3282(01)00614-7.CrossRefPubMed
Metadata
Title
“Burden of osteoporotic fractures in primary health care in Catalonia (Spain): a population-based study”
Authors
Aina Pagès-Castellà
Cristina Carbonell-Abella
Francesc Fina Avilés
Maite Alzamora
Jose Miguel Baena-Díez
Daniel Martínez Laguna
Xavier Nogués
Adolfo Díez-Pérez
Daniel Prieto-Alhambra
Publication date
01-12-2012
Publisher
BioMed Central
Published in
BMC Musculoskeletal Disorders / Issue 1/2012
Electronic ISSN: 1471-2474
DOI
https://doi.org/10.1186/1471-2474-13-79

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