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BMC Musculoskeletal Disorders
Published in: BMC Musculoskeletal Disorders 1/2011

Open Access 01-12-2011 | Research article

Hyperadiponectinemia enhances bone formation in mice

Authors: Yasuhiro Mitsui, Masafumi Gotoh, Nobuhiro Fukushima, Isao shirachi, Shuichi Otabe, Xiaohong Yuan, Toshihiko Hashinaga, Nobuhiko Wada, Akiko Mitsui, Tatsuhiro Yoshida, Shiro Yoshida, Kentaro Yamada, Kensei Nagata

Published in: BMC Musculoskeletal Disorders | Issue 1/2011

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Abstract

Background

There is growing evidence that adiponectin, a physiologically active polypeptide secreted by adipocytes, controls not only adipose tissue but also bone metabolism. However, a role for adiponectin in bone development remains controversial.

Methods

We therefore investigated the endocrine effects of adiponectin on bone metabolism using 12-week-old male transgenic (Ad-Tg) mice with significant hyperadiponectinemia overexpressing human full-length adiponectin in the liver.

Results

In Ad-Tg mice, the serum level of osteocalcin was significantly increased, but the levels of RANKL, osteoprotegerin, and TRAP5b were not. Bone mass was significantly greater in Ad-Tg mice with increased bone formation. In contrast, bone resorption parameters including the number of osteoclasts and eroded surface area did not differ between Ad-Tg and their littermates.

Conclusions

These findings demonstrate that hyperadiponectinemia enhances bone formation in mice.
Appendix
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Metadata
Title
Hyperadiponectinemia enhances bone formation in mice
Authors
Yasuhiro Mitsui
Masafumi Gotoh
Nobuhiro Fukushima
Isao shirachi
Shuichi Otabe
Xiaohong Yuan
Toshihiko Hashinaga
Nobuhiko Wada
Akiko Mitsui
Tatsuhiro Yoshida
Shiro Yoshida
Kentaro Yamada
Kensei Nagata
Publication date
01-12-2011
Publisher
BioMed Central
Published in
BMC Musculoskeletal Disorders / Issue 1/2011
Electronic ISSN: 1471-2474
DOI
https://doi.org/10.1186/1471-2474-12-18

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